Neutrophil faggot cells and inv(16): not such a fortuitous association?

A Case of Acute Myeloid Leukemia With inv(16)(p13.1q22);CBFB-MYH11 Presenting With Faggot Cells

“…In addition to ours, three AML cases with faggot cells accompanied by inv(16) have been reported [4][5][6]. Two cases were de novo AML with inv(16) harboring a KIT variant, as in our case [4,5], and the other case was therapy-related AML with inv(16)(p13. 1q22) in a patient treated for HIV infection and Hodgkin lymphoma [6].…”

“…Faggot cells presence in AML with recurrent genetic abnormalities (by 2017 WHO classification) other than APL has been mainly reported to accompany core binding factor (CBF) variants, especially, t(8;21) and inv(16) [4][5][6][7]. CBF variants cause CBF complex decomposition to block cell differentiation.…”

Auer rods and faggot cells: A review of the history, significance and mimics of two morphological curiosities of enduring relevance

“…Infrequently, faggot cells are also reported in patients with AML other than APL (Table 2). 53–65 These cases were diagnosed as AML with inv(16) in four cases, mixed‐phenotype acute leukemia (T/Myeloid) in two cases, and one each of AML without maturation (M1), AML with complex karyotype involving chromosome 11, MDS‐refractory anemia with excess blasts‐2, AML with myelodysplasia‐related changes, AML‐M4, AML with t(8;21) and AML with t(7;11). Median age was 32 years (interquartile range [IQR] 13–67) and the male to female ratio was 2.2:1.…”

“…52 Infrequently, faggot cells are also reported in patients with AML other than APL (Table 2). [53][54][55][56][57][58][59][60][61][62][63][64][65]…”

Faggot cells in therapy‐related acute myeloid leukemia with inv(16)

“…Furthermore, it is important to note that inv(16) should be dismissed when atypical pre‐eosinophilic granulation is found. Neutrophil faggot cells are a very uncommon feature described in t‐AML with inv(16), 2 with a single case reported in literature 1 …”