A Case of Acute Myeloid Leukemia With inv(16)(p13.1q22);C<i>BFB-MYH11</i> Presenting With Faggot Cells

Kim, Jung-Ah; Shin, Woo Yong; Kim, Jieun; Bang, Hae In; Yoon, Seug Yun; Won, Jong-Ho; Park, Rojin

doi:10.3343/alm.2021.41.3.333

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Infrequently, faggot cells are also reported in patients with AML other than APL (Table 2). 53–65 These cases were diagnosed as AML with inv(16) in four cases, mixed‐phenotype acute leukemia (T/Myeloid) in two cases, and one each of AML without maturation (M1), AML with complex karyotype involving chromosome 11, MDS‐refractory anemia with excess blasts‐2, AML with myelodysplasia‐related changes, AML‐M4, AML with t(8;21) and AML with t(7;11). Median age was 32 years (interquartile range [IQR] 13–67) and the male to female ratio was 2.2:1.…”

Section: Faggot Cells and Their Occurrence In Non‐apl Neoplasmsmentioning

confidence: 99%

Auer rods and faggot cells: A review of the history, significance and mimics of two morphological curiosities of enduring relevance

Sehgal

Sharma

2022

European J of Haematology

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Myeloid differentiation in blasts is distinguished by the presence of one or more needle-shaped crystalline structures called Auer rods. Auer rods manifest either alone or as faggot cells (containing bundles of Auer rods) in various types of acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and myelodysplastic/ myeloproliferative neoplasms (MDS/MPN). Their presence largely portends a better prognosis in AML (as markers of maturation/differentiation) and upstages cases of MDS and MDS/MPN. Observation of these rods in residual blasts in treated cases of AML indicates an absence of remission. This article traces their historical discovery and examines their pathogenetic intricacies, as well as our current understanding of their relevance in myeloid neoplasms. Studies evaluating their prognostic impact in AML and MDS are catalogued. We also discuss a variety of other hematological and non-hematological neoplasms where structures potentially mistakable for Auer rods have been described. Even as the diagnostic approach to hematological malignancies has evolved from a morphology + cytochemistry + immunophenotyping-dependent one in the last century to a predominantly molecular genetics-based classification currently, and even as high-throughput sequencing and structural variation detection techniques surpass morphology in detecting clinically-relevant sub-categories of similar-appearing tumours, we review these curious microscopic structures that have withstood the test of time with respect to their diagnostic relevance.

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Section: Faggot Cells and Their Occurrence In Non‐apl Neoplasmsmentioning

confidence: 99%