Sepsis - one of the leading cause of death on the planet, mortality rate in septic shock can be up to 50%. Timely treatment start and outcomes of disease are directly depend from early and precise diagnostics of sepsis. For the present, the “golden standart” in diagnosing sepsis is growing blood culture from patient’s’ samples. However, taking into account necessarity of fast descision making about starting intensive threatment, speed of blood culture test for quick descision about starting theratment is insufficient. At the same time, modern laboratory medicine have wide spectre of different biomarkers, which can be applied in diagnosing sepsis. In literature review discussed main biomarkers, used in sepsis diagnostics.