Neutron versus photon irradiation for unresectable salivary gland tumors: Final report of an RTOG-MRC randomized clinical trial

Laramore, George E.; Krall, John M.; Griffin, Thomas W.; Duncan, W.; Richter, M.; Saroja, K.R.; Maor, Moshe; Davis, Lawrence W.

doi:10.1016/0360-3016(93)90233-l

Cited by 265 publications

(169 citation statements)

References 27 publications

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“…Further therapy strategies recommend on a type-2 level of evidence [14] in cases of unresectable/inoperable locoregional disease neutron, heavy ions or proton radiotherapy. But there are still controversies concerning radiotherapy, on the one hand surgical resection and postoperative RT is recommended [15].…”

Section: Discussionmentioning

confidence: 99%

Malignant minor salivary gland tumors: a retrospective study of 27 cases

Kruse

Grätz

Obwegeser

et al. 2010

Oral Maxillofac Surg

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Purpose Malignant tumors of the intra-oral minor salivary glands are uncommon. The aim of this study was to give information concerning the clinical features of these tumors, the distribution of location, treatment opportunities, and outcome. Methods Twenty-seven patients with malignant salivary gland tumors that were treated between January 1999 and December 2008 were evaluated retrospectively. Results Of the 27 minor salivary gland carcinomas, 48.1% were adenoid cystic carcinomas (ACC), 29.7% mucoepidermoid carcinomas (MEC), 22.2% adenocarcinomas (ADCA). The most common first symptom was a painless swelling in 60% of the cases, with the second most common symptom being ulcers (28%). Four recurrences and two metastases were found. No recurrence was observed in ADCA. All four patients experiencing a recurrence developed it in the first 3 years after treatment. Conclusion Wide excision with a clinical margin of 1 cm and in large tumors, positive surgical margins or perineural infiltration and postoperative radiotherapy (RT) can be recommended; but in order to give exact information concerning the possible benefit from postoperative RT, it needs large prospective multicenter studies. Long-term follow-up controls and in particularly longer than 5 years in ACC including yearly chest X-rays should be offered to these patients because of late metastasis and recurrences.

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Section: Discussionmentioning

confidence: 99%

Malignant minor salivary gland tumors: a retrospective study of 27 cases

Kruse

Grätz

Obwegeser

et al. 2010

Oral Maxillofac Surg

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“…Randomized trials have confirmed that neutron radiation achieves superior results to those of conventional photon radiation in the treatment of salivary gland tumors and prostate cancer (2,3). In addition, retrospective experience suggests that other tumors, such as utiresectable soft tissue and bone sarcomas are more effectively treated with fast neutrons compared to conventional photon treatment (4).…”

Section: Discussionmentioning

confidence: 99%

“…Fast neutron radiotherapy has been extensively studied in human trials with clear advantages demonstrated over conventional photon radiation for certain neoplasms, but only equivalent results in the majority of tumors (2)(3)(4)(5)(6)(7). BNCT has yet to develop 308 T. A. RUCHHOLZ ET AL into a clinically useful tool.…”

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confidence: 99%

Enhancement of Fast Neutron Beams with Boron Neutron Capture Therapy: A mechanism for achieving a selective, concomitant tumor boost

et al. 1994

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“…Currently, there are only five operating centers worldwide, three of them in the United States. Areas where neutrons have shown potential benefits include salivary gland tumors (specifically, adenoid cystic carcinoma), [41][42][43] squamous cell carcinomas of the head and neck, 44,45 non-small cell lung cancer, 46 prostate cancer, [47][48][49] and sarcomas. 50 …”

Section: Fast Neutron Therapymentioning

confidence: 99%

Radiation Techniques in Neuro-Oncology

Khuntia

Mehta

2009

Neurotherapeutics

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Summary: Radiation therapy plays a critical role in the management of tumors of the brain. A variety of radiotherapy techniques have been used to treat these tumors. This review describes both classic and more recent and advanced techniques available to manage these tumors. Included is a discussion of standard two-and three-dimensional radiation, as well as intensity-modulated radiotherapy, image-guided radiation therapy, stereotactic radiosurgery, and heavy particles.

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Neutron versus photon irradiation for unresectable salivary gland tumors: Final report of an RTOG-MRC randomized clinical trial

Cited by 265 publications

References 27 publications

Malignant minor salivary gland tumors: a retrospective study of 27 cases

Malignant minor salivary gland tumors: a retrospective study of 27 cases

Enhancement of Fast Neutron Beams with Boron Neutron Capture Therapy: A mechanism for achieving a selective, concomitant tumor boost

Radiation Techniques in Neuro-Oncology

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