Enhancement of Fast Neutron Beams with Boron Neutron Capture Therapy: A mechanism for achieving a selective, concomitant tumor boost

Buchholz, Thomas A.; Laramore, George E.; Wootton, P.; Livesey, John C.; Wilbur, D. Scott; Risler, R.; Phillips, Mark H.; Jacky, Jonathan; Griffin, Thomas W.

doi:10.3109/02841869409098422

Cited by 9 publications

(3 citation statements)

References 16 publications

(15 reference statements)

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“…The reported studies provide new information on the physical and dosimetric characteristics of fast neutrons produced by 50.5 MeV protons incident on a Be target, and document in detail the physical and radiological characteristics of key components of the CNTS treatment head, including the primary collimator, MLC, and flattening filters. A CNTS model that fully characterizes the in and out-of-field beam characteristics is needed to more accurately model the energy response of neutron dosimeters and measurement devices and to examine the feasibility of advanced forms of neutron therapy (Buchholz et al 1994, Laramore et al 1996b as well as neutron therapy in combination with MV x-rays or protons, i.e. multi-modal radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

“…to enable BECT. For example, in vitro studies of V79 cell survival after irradiation by CNTS fast neutrons with ~50 µg g −1 of 10 B have confirmed that cell killing increases by about an order of magnitude compared to cell survival without 10 B (Buchholz et al 1994). Although past clinical trials have shown that local tumor control can be achieved using non-conformal thermal or epithermal neutron beams (i.e.…”

Section: Tissue Maximum Ratio (Tmr) and Characteristics Of A Nominal ...mentioning

confidence: 99%

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MCNP6 model of the University of Washington clinical neutron therapy system (CNTS)

et al. 2016

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A MCNP6 dosimetry model is presented for the Clinical Neutron Therapy System (CNTS) at the University of Washington. In the CNTS, fast neutrons are generated by a 50.5 MeV proton beam incident on a 10.5 mm thick Be target. The production, scattering and absorption of neutrons, photons, and other particles are explicitly tracked throughout the key components of the CNTS, including the target, primary collimator, flattening filter, monitor unit ionization chamber, and multi-leaf collimator. Simulations of the open field tissue maximum ratio (TMR), percentage depth dose profiles, and lateral dose profiles in a 40 cm × 40 cm × 40 cm water phantom are in good agreement with ionization chamber measurements. For a nominal 10 × 10 field, the measured and calculated TMR values for depths of 1.5 cm, 5 cm, 10 cm, and 20 cm (compared to the dose at 1.7 cm) are within 0.22%, 2.23%, 4.30%, and 6.27%, respectively. For the three field sizes studied, 2.8 cm × 2.8 cm, 10.4 cm × 10.3 cm, and 28.8 cm × 28.8 cm, a gamma test comparing the measured and simulated percent depth dose curves have pass rates of 96.4%, 100.0%, and 78.6% (depth from 1.5 to 15 cm), respectively, using a 3% or 3 mm agreement criterion. At a representative depth of 10 cm, simulated lateral dose profiles have in-field (⩾ 10% of central axis dose) pass rates of 89.7% (2.8 cm × 2.8 cm), 89.6% (10.4 cm × 10.3 cm), and 100.0% (28.8 cm × 28.8 cm) using a 3% and 3 mm criterion. The MCNP6 model of the CNTS meets the minimum requirements for use as a quality assurance tool for treatment planning and provides useful insights and information to aid in the advancement of fast neutron therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Tissue Maximum Ratio (Tmr) and Characteristics Of A Nominal ...mentioning

confidence: 99%

MCNP6 model of the University of Washington clinical neutron therapy system (CNTS)

et al. 2016

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“…Nowadays, the modern oncologic therapy uses various techniques for cancer treatment such as surgery, radiation and chemotherapy. Among them are several therapeutic techniques for neutron radiotherapy, namely: (i) fast neutron radiotherapy; (ii) neutron capture therapy (NCT), most notably BNCT (boron NCT) [1,2]; and (iii) a combination of BNCT and a fast neutron radiotherapy [3]. Several other combinations are also known, such as, for example, BNCT supplemented by an external X-ray beam [4].…”

Section: Introductionmentioning

confidence: 99%

A Dual-Beam Irradiation Facility for a Novel Hybrid Cancer Therapy

Sabchevski

Idehara

Ishiyama

et al. 2012

J Infrared Milli Terahz Waves

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Abstract:In this paper we present the main ideas and discuss both the feasibility and the conceptual design of a novel hybrid technique and equipment for an experimental cancer therapy based on the simultaneous and/or sequential application of two beams, namely a beam of neutrons and a CW (continuous wave) or intermittent sub-terahertz wave beam produced by a gyrotron for treatment of cancerous tumors. The main simulation tools for the development of the computer aided design (CAD) of the prospective experimental facility for clinical trials and study of such new medical technology are briefly reviewed. Some tasks for a further continuation of this feasibility analysis are formulated as well.

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