Neutralization of Teratogenic and Lethal Effects of Influenza-A Virus in Chick Embryos.

Abstract

523of the liver (respiratory decline in the Warburg) and subsequent dietary necrotic liver degeneration when fed a vit. E-free ration containing 30% Torula yeast as the sole source of protein. Depressed liver CoA values are observed in such animals. It is shown that CoA is not elevated by feeding of protective amounts of vit. E or Factor 3. Cystine, methionine, and cysteine, on the other hand, which promote growth under these conditions, raise the liver CoA values to nearnormal levels. This action is not correlated to the varying degree of protection against liver necrosis and against the prenecrotic respiratory decline afforded by the individual S-amino acids. Hence, there is no apparent etiological relationship between concentration of CoA in the liver and the development of dietary necrotic liver degeneration.

Congenital Heart Disease and Other Malformations Produced by Influenza A Virus and Allantoic Fluid in the Chick Embryo

“…This disagreement in results may be attributed to the fact that in this study inoculations were performed at an earlier stage of development (17 hours of incubation) than in the other au- thors' experiments (48 hours of incubation). The appearance of lethal malformations Avas to be expected, considering Wilson's statement 10 that teratogenic agents acting on the embryo early in development, when differentiation begins, can produce more malformations-and more severe ones-than the same agents acting later. The beginning of differentiation is a period of maximum susceptibility for every individual organ and system.…”

Infection of the One-Day Old Fertile Hen's Egg With Rabies Virus

“…Hamburger and Habel (1947) infected 2-day old eggs with influenza and mumps viruses and found embryonic anomalies in a high proportion. Shear et al (1955) demonstrated that this teratogenic effect by influenza virus could be neutralized by antiserum. A similar teratogenic effect was noted with Newcastle disease virus (Williamson et al, 1953).…”