2009
DOI: 10.1002/ptr.2735
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Neutralization of local and systemic toxicity of Daboia russelii venom by Morus alba plant leaf extract

Abstract: Antivenom therapy is the current best therapy available for the treatment of fatal snake envenomation. However, the antivenom offers less or no protection against local effects such as extensive edema, hemorrhage, dermo-, myonecrosis and inflammation at the envenomed region. Viperidae snakes are highly known for their violent local effects and such effects have been commonly treated with plant extracts without any scientific validation in rural India. In this investigation Morus alba plant leaf extract has bee… Show more

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Cited by 26 publications
(13 citation statements)
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“…Many plants components have been used as folk and traditional medicine as active ingredient against snakebites (Soares et al, 2005;Bhattacharjee and Bhattacharyya, 2013a, b). Venoms from viperidae snakes (D. russelli russelli) cause several local effects that are commonly treated with plant extracts without any scientific validation in tribal areas of India (Chandrashekara et al, 2009;Harsha et al, 2002Harsha et al, , 2003. Preliminary screening of some medicinal plant roots extract towards inhibition of DR-PDE was done.…”
Section: Discussionmentioning
confidence: 99%
“…Many plants components have been used as folk and traditional medicine as active ingredient against snakebites (Soares et al, 2005;Bhattacharjee and Bhattacharyya, 2013a, b). Venoms from viperidae snakes (D. russelli russelli) cause several local effects that are commonly treated with plant extracts without any scientific validation in tribal areas of India (Chandrashekara et al, 2009;Harsha et al, 2002Harsha et al, , 2003. Preliminary screening of some medicinal plant roots extract towards inhibition of DR-PDE was done.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, it is ineffective in protecting venom-induced haemorrhage, necrosis, nephrotoxicity and local tissue damage. Further, antisera development is a tedious, costly and time-consuming process and requires strict storage conditions (Chandrashekara, Nagaraju, Nandini, Basavaiah, & Kemparaju, 2009;Mahadeswaraswamy, Nagaraju, Girish, & Kemparaju, 2008). Due to these difficulties in antiserum therapy, many medicinal plants have been recommended for treating snake bites (R. Chopra, Nayar, & I. Chopra, 1956).…”
Section: Introductionmentioning
confidence: 99%
“…Antivenom development is time consuming, expensive, and requires ideal storage conditions (Gutiérrez et al, 1998;León et al, 2000), and therefore, alternative therapies are in demand (Mahadeswaraswamy et al, 2009). For ages, plants were used to antagonize the toxic effects of snake venom, but this has lately gained growing scientific attention (Mors et al, 2000;Asuzu and Harvey, 2003;Borges et al, 2005;da Silva et al, 2005;Ode and Asuzu, 2006;Vale et al, 2008;Mahadeswaraswamy et al, 2008Mahadeswaraswamy et al, , 2009Chandrashekara et al, 2009;Tan et al, 2009;Assafim et al, 2011;Fung et al, 2010Fung et al, , 2011.…”
Section: Introductionmentioning
confidence: 98%