Neutralization of edema, hemorrhage and myonecrosis induced by North American crotalid venoms in simulated first-aid treatments

Para-Bromophenacyl bromide alleviates airway hyperresponsiveness and modulates cytokines, IgE and eosinophil levels in ovalbumin-sensitized and -challenged mice

“…Consequently, a major thrust has been given to identify non-steroidal anti-inflammatory molecules for mitigating these disorders. In view of this, we selected para-Bromophenacyl bromide (PBPB), a known inhibitor of PLA 2 , which has been shown to inhibit various steps of inflammation such as edema [8,9] and superoxide (O 2 À ) release [10]. It has also been shown to inhibit OVA and PAF-induced contraction of guinea pig lung strips [11].…”

Inhibitory effects on phospholipase A2 and antivenin activity of melanin extracted from Thea sinensis Linn

“…MEBT was taken at a concentration of 10 mg/ml. PLA 2 activity was determined using assay based on release of free fatty acids from L-phosphatidylcholine (Evans and Ownby, 1999) employed with minimal adjustments. Accumulation of free fatty acids was monitored at 578 nm using cresol red as indicator.…”

Effects of Sodium Silicate Complex against Hemorrhagic Activities Induced by Protobothrops mucrosquamatus Venom

“…The mainstay therapy of snake envenoming is the intravenous administration of animalderived antivenoms, including IgG, fragments F(ab) and F(ab )2. Although antivenom therapy is largely successful in reducing the mortality associated with snake envenoming, the efficacy of antivenom administration against local symptoms has been limited due to rapid development of damage at the bite sites [3][4][5].…”