Neurotrophins: Role in adverse pregnancy outcome

Dhobale, Madhavi

doi:10.1016/j.ijdevneu.2014.06.005

Cited by 45 publications

(35 citation statements)

References 86 publications

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“…In humans, BDNF levels are altered in attentional, neurodevelopmental, and stress-related mood and anxiety disorders [17–21]. At birth, higher maternal blood but lower cord blood and placental BDNF levels are associated with prematurity and lower gestational age [22–26], with cord blood levels also predicting birth complications [27, 28]. …”

Section: Introductionmentioning

confidence: 99%

BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

et al. 2017

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BackgroundThe BDNF gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critical roles throughout the body and is essential for placental and fetal development. Rodent studies show that early life stress, including prenatal stress, broadly alters BDNF methylation, with presumed changes in gene expression. No studies have assessed prenatal exposure to maternal traumatic stress and BDNF methylation in humans. This study examined associations of prenatal exposure to maternal stress and BDNF methylation at CpG sites across the BDNF gene.ResultsAmong 24 mothers and newborns in the eastern Democratic Republic of Congo, a region with extreme conflict and violence to women, maternal experiences of war trauma and chronic stress were associated with BDNF methylation in umbilical cord blood, placental tissue, and maternal venous blood. Associations of maternal stress and BDNF methylation showed high tissue specificity. The majority of significant associations were observed in putative transcription factor binding regions.ConclusionsThis is the first study in humans to examine BDNF methylation in relation to prenatal exposure to maternal stress in three tissues simultaneously and the first in any mammalian species to report associations of prenatal stress and BDNF methylation in placental tissue. The findings add to the growing body of evidence highlighting the importance of considering epigenetic effects when examining the impacts of trauma and stress, not only for adults but also for offspring exposed via effects transmitted before birth.Electronic supplementary materialThe online version of this article (doi:10.1186/s13148-017-0367-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

et al. 2017

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“…[1] By separating the immature fetus from the placenta, a very preterm delivery months before term results in the sudden and complete withdrawal of these growth factors and of the sustenance they provide. [2]…”

Section: Introductionmentioning

confidence: 99%

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

et al. 2017

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Aim To identify the antecedents and very early correlates of low concentrations of neurotrophic growth factors in the blood of extremely preterm newborns during the first postnatal month. Methods Using an immunobead assay, we measured the concentrations of neurotrophin 4 (NT4), brain-derived neurotrophic factor (BDNF), and basic fibroblast growth factor (bFGF) in blood spots collected on postnatal days 1(N=1062), 7 (N=1087), 14 (N=989), 21 (N = 940) and 28 (N = 880) from infants born before the 28th week of gestation. We then sought the correlates of measurements in the top and bottom quartiles for gestational age and day the specimen was collected. Results The concentrations of 2 neurotrophic proteins, NT4 and BDNF, were low among children delivered for medical (maternal or fetal) indications, and among those who were growth restricted. Children who had top quartile concentrations of NT4, BDNF, and bFGF tended to have elevated concentrations of inflammation-related proteins that day. This pattern persisted for much of the first postnatal month Conclusions Delivery for medical indications and fetal growth restriction are associated with a relative paucity of NT4 and BDNF concentrations during the first 24 hours after very preterm birth. Elevated blood concentrations of NT4, BDNF, and bFGF tended to co-occur with indicators of systemic inflammation on the same day.

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“…The expression of TrkB as well as both BDNF and NT4 persists in placental trophoblast cells following implantation and appears to be necessary for continued placental development . Furthermore, it has been suggested that these neurotrophins are also involved in the promotion of angiogenesis during embryo development . BDNF levels have been shown to be higher in non‐pregnant than in pregnant women, did not vary during the phases of the menstrual cycle, were lowest in pregnant women during the 1st trimester and similar during the 2nd and 3rd trimesters …”

Section: Introductionmentioning

confidence: 99%

Reduced Circulating Concentration of Brain‐derived Neurotrophic Factor is Associated with Peri‐ and Post‐implantation Failure following In Vitro Fertilization–Embryo Transfer

Ramer

Kruczek

Doulaveris

et al. 2015

American J Rep Immunol

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Neurotrophins: Role in adverse pregnancy outcome

Cited by 45 publications

References 86 publications

BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

Reduced Circulating Concentration of Brain‐derived Neurotrophic Factor is Associated with Peri‐ and Post‐implantation Failure following In Vitro Fertilization–Embryo Transfer

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