Neurotrophins in bladder function: What do we know and where do we go from here?

Cruz, Célia Duarte

doi:10.1002/nau.22438

Cited by 64 publications

(60 citation statements)

References 128 publications

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“…Given the known density of sensory afferents in the bladder, we hypothesized that a common pathway of stress expression may involve urinary solutes. Catecholamines (byproducts of cortisol metabolism) and neuropeptides including NGF and BDNF previously shown to be elevated in some patients with OAB were measured [31]. …”

Section: Methodsmentioning

confidence: 99%

Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder

et al. 2016

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Introduction and hypothesis The aim of this study was to measure physiologic and psychologic stress reactivity in women with overactive bladder (OAB). There is growing evidence in preclinical models that central nervous system dysregulation, particularly in response to psychological stress, may contribute to lower urinary tract symptoms in women with OAB. Methods Postmenopausal women with OAB and healthy controls underwent Structured Clinical Interview for DSM-IV Axis I disorders (SCID) to identify those without identifiable psychiatric disease. Eligible participants underwent physiologic measures including basal (cortisol-awakening response; CAR) and stress-activated salivary cortisol levels, heart rate (HR), urinary metanephrines and neurotrophins, as well as validated symptom assessment for stress, anxiety, depression, and bladder dysfunction at baseline and during, and following an acute laboratory stressor, the Trier Social Stress Test (TSST). Results Baseline measures of cortisol reactivity measured by CAR showed blunted response among women with OAB (p = 0.015), while cortisol response to the TSST was greater in the OAB group (p = 0.019). Among OAB patients, bladder urgency as measured by visual analog scale (VAS) increased from pre- to post-TSST (p = 0.04). There was a main effect of TSST on HR (p < 0.001), but no group interaction. Conclusions Preliminary findings suggest that women with OAB have greater physiologic and psychologic stress reactivity than healthy controls. Importantly for women with OAB, acute stress appears to exacerbate bladder urgency. Evaluation of the markers of stress response may suggest targets for potential diagnostic and therapeutic interventions.

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Section: Methodsmentioning

confidence: 99%

Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder

et al. 2016

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“…Increased urinary NGF levels are associated with bladder inflammation associated with chemical irritation, detrusor overactivity, and BOO (37). The role of NGF in the neurotrophic effects associated with obstruction was first identified by Steers et al in 1991 (38).…”

Section: Biomarkersmentioning

confidence: 99%

New Frontiers in Molecular and Imaging Research on Evaluation and Diagnosis of Bladder Outlet Obstruction in Women

Martínez

Khavari

2017

Curr Bladder Dysfunct Rep

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Purpose Diagnosis of bladder outlet obstruction (BOO) often presents a challenge in female patients. Traditional diagnostic elements such as symptom history and urodynamic data are rarely clear cut in women. Therefore, we sought to review the current literature on diagnosis of female BOO, focusing on new frontiers in the realm of molecular markers and imaging modalities. Recent Findings In addition to fluoroscopy in the setting of videourodynamics, ultrasound and MRI can augment the diagnosis and aid in therapeutic planning in certain etiologies of female BOO. Furthermore, multiple potential biomarkers (i.e. nerve growth factor, prostaglandins, ATP) that have been studied in correlation to BOO in animal models as well as human subjects hold promise for diagnostic applications. Summary These novel techniques may augment standard clinical and urodynamic evaluation of BOO in females. Future directions include further studies of each of these biomarkers in female patients with BOO compared to normal controls to test their feasibility as potential screening tools.

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“…Subsequent studies have revealed that NGF is a target-derived trophic factor that promotes neuronal innervation and axonal terminal branching during development and has roles in the maintenance of neural homeostasis in adult. In the visceral organs, NGF and its receptor TrkA are found for their expression in neuronal and non-neuronal structures of the gut (Lin et al, 2005; Barada et al, 2007; Stanzel et al, 2008; Qiao and Grider, 2010), and NGF and TrkA are also expressed by the urinary bladder epithelial cells and detrusor muscle (see review (Cruz, 2014)). Pancreatic β cells are able to synthesize and secrete NGF (Rosenbaum et al, 1998) which can lead to selective hyperinnervation of the islets when NGF is overexpressed (Edwards et al, 1989).…”

Section: Neurotrophin Signaling In the Visceramentioning

confidence: 99%

“…BDNF is also found to express in non-neuronal tissues such as gut mucosa, adipocytes, liver, lung, pancreas and the urinary bladder (Lommatzsch et al, 1999; Bonini et al, 2001; Lucini et al, 2003; Lommatzsch et al, 2005; Grider et al, 2006; Steinkamp et al, 2012; Yu et al, 2012; Cruz, 2014). Its role in peripheral tissues is less studied.…”

Section: Neurotrophin Signaling In the Visceramentioning

confidence: 99%

Neurotrophin signaling and visceral hypersensitivity

Qiao

2014

Front. Biol.

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Neurotrophin family are traditionally recognized for their nerve growth promoting function and are recently identified as crucial factors in regulating neuronal activity in the central and peripheral nervous systems. The family members including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) are reported to have distinct roles in the development and maintenance of sensory phenotypes in normal states and in the modulation of sensory activity in disease. This paper highlights receptor tyrosine kinase (Trk) -mediated signal transduction by which neurotrophins regulate neuronal activity in the visceral sensory reflex pathways with emphasis on the distinct roles of NGF and BDNF signaling in physiologic and pathophysiological processes. Viscero-visceral cross-organ sensitization exists widely in human diseases. The role of neurotrophins in mediating neural cross talk and interaction in primary afferent neurons in the dorsal root ganglia (DRG) and neurotrophin signal transduction in the context of cross-organ sensitization are also discussed.

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Neurotrophins in bladder function: What do we know and where do we go from here?

Abstract: Available data show that our knowledge of NTs has greatly increased in recent years and that some results may have future clinical application.

Cited by 64 publications

References 128 publications

Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder

Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder

New Frontiers in Molecular and Imaging Research on Evaluation and Diagnosis of Bladder Outlet Obstruction in Women

Neurotrophin signaling and visceral hypersensitivity

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