Neurotransmitters / Neuromodulators Involved in the Motor and Secretory Functions of the Ruminant Stomach: A Histochemical , Radioimmunological , Immunocytochemical and Functional Approach

Weyns, A.; Ooms, L.; Verhofstad, A.; Peeters, Th.; Degryse, Anne‐Dominique; Nassauw, Luc Van; Krediet, P

doi:10.1007/978-94-009-3319-4_3

Cited by 8 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the period of RSA of the cycle of MMCs on the duodenal bulb is considered as the indicator for the timing of cyclic events in the sheep, it is obvious that the effect is more pronounced at this site. This is in agreement with the antroduodenal origin of MMCs in the ovine species (193) and the high concentrations of neurotransmitters at this level (254). Comparison of the effects of methysergide in the ovine model with other species indicates a rather specific response in the ruminant species, which always exhibit an enhancement of the cyclic motor activity instead of only an increased activity, e.g., as in dogs.…”

Section: -Hydroxytryptaminesupporting

confidence: 84%

Gastrointestinal motor functions in ruminants

Ruckebusch

1989

Comprehensive Physiology

View full text Add to dashboard Cite

Section: -Hydroxytryptaminesupporting

confidence: 84%

Gastrointestinal motor functions in ruminants

Ruckebusch

1989

Comprehensive Physiology

View full text Add to dashboard Cite

“…The circular muscle strips from the reticular groove were more sensitive to VIP than the longitudinal muscle strips. Interesting in this context is the observation of WEYNS et al (1987) showing that the VIP-ergic innervation in the circular muscle layer of the reticular groove is richer than that in the longitudinal muscle layer. VIP similarly affected the circular smooth muscle preparations from the R O O of the calf.…”

Section: Discussionmentioning

confidence: 99%

Relaxation of Muscle Strips from the Reticular Groove and Reticulo‐Omasal Orifice by Vasoactive Intestinal Peptide (VIP)

Denac

Oertle

Kümin

et al. 1990

Journal of Veterinary Medicine Series A

View full text Add to dashboard Cite

The effect of Vasoactive Intestinal Peptide (VIP) on muscle strips from the reticular groove, the reticulo-omasal orifice (ROO) and the omasal canal was studied. VIP caused a concentrationdependent (10-8-5 .10-7 mol/l) reduction of the acetylcholine-induced (55 . mol/l) contraction of the reticular groove muscle preparations from calves and adult cattle. VIP was more effective in the muscle strips from calves than in those from adult cattle. Moreover, the circular muscle strips from the reticular groove were more sensitive to VIP than the longitudinal muscle strips.VIP also induced a concentration-related (10+-5 . io-'mol/l) relaxation of muscle strips from the calf ROO. Furthermore, both circular and longitudinal muscle strips from the omasal canal of the calf were relaxed by VIP (10-'-5~10-7m0l/l). The relaxing effect of VIP on the circular muscle strips from the reticular groove of the calf was not significantly affected during incubation with 5 . 10dmoVl tetrodotoxin. The relaxing effect of VIP therefore seems to be mediated by VIP receptors of smooth muscle cells.These properties of VIP in conjunction with its presence in nerve fibres located in the wall of the reticular groove and ROO are consistent with a role of VIP as inhibitory transmitter in this region of the bovine stomach.

show abstract

“…In the omasal musculature, Walhuta [I986| and Weyns et al [1987] reported the existence of the nerves with SPand VIP-like immunoreactivity. The present results showed further information about the distribution pattern of the peptidergic and catecholaminergic nerves.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Study of the Distributions of the Peptide- and Catecholamine-Containing Nerves in the Omasum of the Sheep

Yamamoto¹,

Kitamura²,

Yamada³

et al. 1994

Cells Tissues Organs

View full text Add to dashboard Cite

The distribution in the sheep omasum of peptide- and catecholamine-containing neurons was investigated by an immunohistochemical technique using antibodies against six neuropeptides and two catecholamine-synthesizing enzymes. In the myenteric plexus, both nerve cell bodies and nerve fibers were positively immunostained for substance P (SP), methionine enkephalin (ENK), vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY) and galanin (GAL). In contrast, immunoreactivity specific for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH) and dopamine-β-hydroxylase (DBH) was detected only in nerve fibers. In the omasal wall, nerve fibers with SP- and ENK-like immunoreactivity were prominent in the outer muscle layer, while numerous nerve fibers with VIP-, NPY- and GAL-like immunoreactivity were observed in the inner muscle layer. In the lamina propria mucosae, and in particular in the omasal papillae, a dense network of peptide-containing nerves was found. The distribution of nerves with CGRP-like immunoreactivity was different from that of other immunoreactive nerves. The networks of nerves with TH-, DBH- and NPY-like immunoreactivity were concentrated around the vascular components. The results of this study indicate the complexity of the enteric nervous system in the sheep omasum, reflecting the multiple functions of the nerves in the regulation of motility and/or absorption and secretion.

show abstract

Neurotransmitters / Neuromodulators Involved in the Motor and Secretory Functions of the Ruminant Stomach: A Histochemical , Radioimmunological , Immunocytochemical and Functional Approach

Cited by 8 publications

References 14 publications

Gastrointestinal motor functions in ruminants

Gastrointestinal motor functions in ruminants

Relaxation of Muscle Strips from the Reticular Groove and Reticulo‐Omasal Orifice by Vasoactive Intestinal Peptide (VIP)

Immunohistochemical Study of the Distributions of the Peptide- and Catecholamine-Containing Nerves in the Omasum of the Sheep

Contact Info

Product

Resources

About