Neurotransmisores, señales de calcio y comunicación neuronal

Eguiagaray, Josefina García; Egea, Javier; Bravo‐Cordero, Jose Javier; Garcı́a, Antonio G.

doi:10.1016/s1130-1473(04)70489-3

Cited by 10 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, in filamentous fungi, deletion of Cch1 or Mid1, which are components of a mechanosensing Ca 2+ -channel complex, results in diminished thigmotropic responses, and failure to establish cell polarity [32]. A comparable mechanism of mechanosensing is used by mammals during immune cell activation [33, 34]. A direct link between the increase in [Ca 2+ ] c and the control of transcription, was revealed by the up-regulation of the Ca 2+ /calmodulin dependent kinase CAMK1, and the transcriptional factor CRZA in response to injury.…”

Section: Discussionmentioning

confidence: 99%

Danger signals activate a putative innate immune system during regeneration in a filamentous fungus

et al. 2018

View full text Add to dashboard Cite

The ability to respond to injury is a biological process shared by organisms of different kingdoms that can even result in complete regeneration of a part or structure that was lost. Due to their immobility, multicellular fungi are prey to various predators and are therefore constantly exposed to mechanical damage. Nevertheless, our current knowledge of how fungi respond to injury is scarce. Here we show that activation of injury responses and hyphal regeneration in the filamentous fungus Trichoderma atroviride relies on the detection of two danger or alarm signals. As an early response to injury, we detected a transient increase in cytosolic free calcium ([Ca2+]c) that was promoted by extracellular ATP, and which is likely regulated by a mechanism of calcium-induced calcium-release. In addition, we demonstrate that the mitogen activated protein kinase Tmk1 plays a key role in hyphal regeneration. Calcium- and Tmk1-mediated signaling cascades activated major transcriptional changes early following injury, including induction of a set of regeneration associated genes related to cell signaling, stress responses, transcription regulation, ribosome biogenesis/translation, replication and DNA repair. Interestingly, we uncovered the activation of a putative fungal innate immune response, including the involvement of HET domain genes, known to participate in programmed cell death. Our work shows that fungi and animals share danger-signals, signaling cascades, and the activation of the expression of genes related to immunity after injury, which are likely the result of convergent evolution.

show abstract

Section: Discussionmentioning

confidence: 99%

Danger signals activate a putative innate immune system during regeneration in a filamentous fungus

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There is evidence that calcium homeostasis, especially in the context of the central nervous system, may have crucial implications in many neuropsychiatric conditions (Yarlagadda, 2002). Mobilization of calcium, both extra-and intracellularly, has tremendous implications in the brain because of its buffering capacity and its second messenger functions (Yarlagadda, 2002;Eguiagaray et al, 2004). It will be interesting to explore whether the up-regulated Tnnt 1 expression is a transient stress response after exogenous insults or portends persistent damage or cascade pathways changes that lead to neuropsychiatric diseases observed in the patients treated with these agents.…”

Section: The Significance Of Tnnt 1 Expression In Adult Mouse Brain Imentioning

confidence: 99%

Molecular stress response in the CNS of mice after systemic exposure to interferon-α, ionizing radiation and ketamine

et al. 2009

View full text Add to dashboard Cite

We previously showed that the expression of troponin T1 (Tnnt 1) was induced in the central nervous system (CNS) of adult mice 30 minutes after treatment with ketamine, a glutamate N-methyl-D-aspartic acid (NMDA) receptor antagonist. We hypothesized that Tnnt 1 expression may be an early molecular biomarker of stress response in the CNS of mice. To further evaluate this hypothesis, we investigated the regional expression of Tnnt

show abstract

“…Biologically active substances such as CART and PV can potentially be involved in the process of neuronal chemical coding change. Based on the chemical content of biologically active substances, various neuronal populations can be determined and their function predicted (Eguiagaray et al 2004). Therefore, the aim of the present study was to immunohistochemically investigate the localization of CART and PV in the hippocampus proper of the chinchilla.…”

Section: Introductionmentioning

confidence: 99%

Polish Journal of Veterinary Sciences

Szalak

Matysek

Kukuła-Koch

et al. 2020

View full text Add to dashboard Cite

This study set out to investigate, for the first time, the distribution and colocalization pattern of cocaine-and amphetamine-regulated transcript (CART) and one of the calcium binding--proteins: parvalbumin (PV) in the chinchilla's hippocampus proper (HP). HP, consisting of Ammon's horn (CA) and the dentate gyrus (DG), is an important component of the limbic system, involved in learning and memory processes. CA showed a higher immunoreactivity of CART (-IR) compared to DG. CART-IR neurons were mainly observed in the molecular layer of DG and in the pyramidal layer of CA. CART-IR fibers were present in the granular layer; in the hilus numerous mossy fibers were detected, while in the molecular layer CART-IR fibers were not found. In all CA fields (CA1-CA3), CART-IR fibers were only present in the lacunosum-molecular layer. Immunofluorescence with double-labeling showed that only CART-IR cells stained positive for PV, whereas in CART-IR fibers there was no PV-positive reaction. Our research supplements missing knowledge about the distribution and colocalization pattern of CART with PV in the chinchilla's hippocampus, and also provides a better understanding of the similarities and differences among individuals of the same species and also with other mammals.

show abstract

Neurotransmisores, señales de calcio y comunicación neuronal

Cited by 10 publications

References 26 publications

Danger signals activate a putative innate immune system during regeneration in a filamentous fungus

Danger signals activate a putative innate immune system during regeneration in a filamentous fungus

Molecular stress response in the CNS of mice after systemic exposure to interferon-α, ionizing radiation and ketamine

Polish Journal of Veterinary Sciences

Contact Info

Product

Resources

About