Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo

Torres-Ruiz, Mónica; González, Mercedes de Alba; Morales, Mónica; Martín-Folgar, Raquel; González, Margarita; Cañas-Portilla, Ana I.; Vieja, Antonio De la

doi:10.1016/j.scitotenv.2023.162406

Cited by 32 publications

(10 citation statements)

References 105 publications

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“…However, boldness is associated with a variety of behaviors, including increased activity, exploration, aggression, dispersal, and even the choice of a mate [ 154 ]. A decrease in social preference could be attributed to other factors, such as MNPs’ effects on sensory organs and the central nervous system, resulting in a hormonal imbalance and, ultimately, reproductive toxicity [ 61 ].…”

Section: Research Methods and Technical Progressmentioning

confidence: 99%

“…MNPs, acting as endocrine disruptors, not only influence the reproductive behavior of aquatic organisms but also significantly impact hormone levels, which are crucial for the development and function of reproductive organs [ 58 , 59 , 60 ]. In zebrafish, a model organism for studying these effects, the disruption of endocrine balance plays a pivotal role in behavioral changes [ 61 ]. During mating, male zebrafish engage in behaviors like chasing females and using specific swimming movements to attract their attention, which are essential for successful fertilization.…”

Section: Association Of Behavioral Changes With Reproductive Toxicitymentioning

confidence: 99%

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Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

Wu,

Yu,

et al. 2024

Toxics

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The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior and reproductive health of aquatic organisms while posing potential risks to human health and ecosystems. This review focuses on the neurobehavioral changes and reproductive toxicity of MNPs in zebrafish and their relationships. At the same time, the neurobehavioral changes caused by MNPs were studied, and the synergistic effects of the interaction of these pollutants with other environmental contaminants were explored. In addition, zebrafish, as a model organism, provide valuable insights into the subtle but important effects of MNPs on reproductive behavior, which is critical for understanding reproductive success, suggesting that behavioral changes can serve as an early biomarker of reproductive toxicity. In addition, based on classical endocrine disruptor models and behavioral research methods, the current status of the research on the reproductive toxicity of MNPs in zebrafish was reviewed, which further indicated that the behavioral parameters of zebrafish can be used as an effective and rapid tool to evaluate the reproductive toxicity of MNPs. However, behavioral methods for rapidly assessing the toxicity of MNPs are still an area of exploration. To address limitations and challenges in the current scope of research, this review outlines future research directions with the aim of improving our understanding of the environmental and health impacts of MNPs. This work aims to inform targeted environmental policies and advance public health strategies to address the growing challenge of MNPs pollution.

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Section: Research Methods and Technical Progressmentioning

confidence: 99%

Section: Association Of Behavioral Changes With Reproductive Toxicitymentioning

confidence: 99%

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

Wu,

Yu,

et al. 2024

Toxics

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“…Oxidative stress has been the most reported damage to a large ammount of aquatic species like algae [21,22,23], fish [24,25,26], daphnia [27,28], clams [29; 30], crayfish [31], sea snail [32], ciliates [33], molluscs [34]. Other effects that were observed as a result of microplastics were mutagenic [35] and carcinogenic [36,37] effects, endocrine disruption [24,38,39,40,41], changes in the feeding [42,43] and swimming [28,44,45,46,47,48] behaviour.…”

Section: Harmful Effects On Aquatic Organismsmentioning

confidence: 99%

The Harmful Effects of Microplastic Pollution on Aquatic Organisms

Yilmaz,

Emecan,

Elhag

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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In recent years, microplastics have been recognized as the most popular pollutants in marine and fresh waters. Plastic is one of the most used materials in all areas of our lives due to its cheap, light, and durable properties. Because they are used as main or auxiliary materials in almost all industries and branches of industry, the disappearance of plastics, which are in our lives, requires very long processes. Since petroleum-derived plastic wastes, which bacteria cannot consume directly, are decomposed by solar heat and radon, only the resulting compounds can be consumed by bacteria. For this reason, awareness-raising efforts to reduce plastic consumption in daily use all over the world have been accelerated. In parallel with this situation, research on microplastic pollution in both seas and inland waters is carried out intensively. Considering the current consumption habits of us humans, who are at the top of the food chain, the rates of microplastics we are exposed to are at a substantial level. The determination of the amount of microplastics contained in seafood consumed as the main protein source is of great importance in terms of public health and shows the necessity of further scientific research on this subject. The purpose of our study is to reveal the effects of microplastic pollution on aquatic organisms both in sea and inland waters by compiling studies on this subject and to draw attention to microplastic pollution in waters.

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“…To address this work, gene expression of different metabolic pathways, such as stress response (hsp27/hspB1, hsp60, hsp70/hspA5, and hsp90α), DNA repair (xrcc1, gad45a, rad51), oxidative damage response (Cu/ZnSOD 1, MnSOD 2), apoptotic response (Cas3a, Cas7, p53, Bcl2), and mitochondrial response (Cox5A), were analyzed after PS NP exposure, as biomarkers of NPs damage. Cells were exposed to concentrations similar to those present in the environment and/or used in previous studies (0.5, 2.5, and 10 μg/mL) for 4 days [11,21,[31][32][33][34]. Currently, there is limited information on the neurotoxicity of NPs in mammals [22] and there are no data on the concentration and bioaccumulation of these nanomaterials in humans.…”

Section: Introductionmentioning

confidence: 99%

“…There is scientific evidence that they can reach the systemic circulation, penetrate, and accumulate in different tissues and organs such as brain, eyes, spleen, liver, bone marrow, etc. [ 9 – 11 ]. Other studies have shown that MPs and NPs produce impacts on development, growth, reproduction, behavior, and mortality in aquatic [ 12 ] and terrestrial animals [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular effects of polystyrene nanoplastics on human neural stem cells

Martin-Folgar,

González-Caballero,

Torres-Ruiz

et al. 2024

PLoS ONE

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Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases.

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Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo

Cited by 32 publications

References 105 publications

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

The Harmful Effects of Microplastic Pollution on Aquatic Organisms

Molecular effects of polystyrene nanoplastics on human neural stem cells

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