Molecular effects of polystyrene nanoplastics on human neural stem cells

Martin-Folgar, Raquel; González-Caballero, Mª Carmen; Torres-Ruiz, Mónica; Cañas-Portilla, Ana I.; de Alba González, Mercedes; Liste, Isabel; Morales, Mónica

doi:10.1371/journal.pone.0295816

Cited by 2 publications

(1 citation statement)

References 109 publications

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“…The researchers found that nanoplastics affected gene expression in a concentration-dependent manner, with some genes being upregulated and others downregulated. They particularly observed significant changes in the expression of stress response genes, including hsp27/hspB1, hsp70/hspA5, and hsp90α, after exposure to nanoplastics 29 .…”

Section: Methodsmentioning

confidence: 99%

The Hidden Health Crisis: Microplastics and Their Medical Consequences

Roman,

Gondko,

Dębiec

et al. 2024

J Educ Health Sport

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Introduction and Purpose: Microplastics, ubiquitous environmental contaminants, are increasingly recognized for their potential to impact human health. This review aims to consolidate existing knowledge on the pathways through which microplastics interact with biological systems and to elucidate their health implications. State of Knowledge: Microplastics are pervasive in various environments, from aquatic to terrestrial ecosystems, and they eventually enter the human body via ingestion, inhalation, or dermal absorption. Studies have suggested that microplastics carry toxic substances, such as heavy metals and organic pollutants, which are known endocrine disruptors and carcinogens. Additionally, the physical presence of microplastics has been linked to inflammation and other negative health outcomes. Research in this field is complex and interdisciplinary, involving toxicology, environmental science, and public health disciplines. Summary: The presence of microplastics in the human body is concerning, and there is a clear need for further research to understand the extent of health risks associated with chronic exposure. Public health strategies should include both reducing microplastic pollution and strengthening regulations on plastic waste. Meanwhile, medical professionals should consider the potential for microplastic exposure when diagnosing and treating chronic conditions. Future research should aim to clarify the mechanisms of toxicity and establish safe levels of exposure, with a multidisciplinary approach being essential for comprehensive understanding and effective intervention.

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Section: Methodsmentioning

confidence: 99%

The Hidden Health Crisis: Microplastics and Their Medical Consequences

Roman,

Gondko,

Dębiec

et al. 2024

J Educ Health Sport

View full text Add to dashboard Cite

show abstract

From the Environment to Molecular Interactions of Nanoplastics: Unraveling the Neurotoxic Impacts and the Implications in Neurodegenerative Processes

Urani,

Barbieri,

Alloisio

et al. 2024

Applied Sciences

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Nanoplastics (NPs) represent an escalating hazard to both humans and the ecosystem due to their pervasive presence. This review delves into (i) the widespread occurrence of NPs across the different environmental matrices, including food; (ii) routes and estimates for human exposure; (iii) the mechanisms of blood–brain barrier (BBB) crossing; and (iv) implications for human health, with a specific focus on molecular features associated with neurotoxicity and neurodegenerative processes. The impact of NPs on the central nervous system, their ability to cross the BBB and the underpinning mechanisms, the potential to initiate neurotoxicity by fostering β-amyloid aggregation, and their interactions with metallo-enzymes (such as superoxide dismutase) are elucidated. The analysis of transcriptomics and epigenomic results, including microRNA dysregulation, unveil how NPs could contribute to neurological disorders. The need for considering overlaps among diverse pathogenetic mechanisms when probing the effects of NPs is discussed. Additional urgent needs are the development of reliable in vitro models for neurotoxicity studies able to mimic the complexity of the nervous system and the exposure of such models to more environmentally relevant NPs. Finally, the development of extremely sensitive detection and analysis methodologies to quantify NPs in environmental and biological matrices is a pressing priority.

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Molecular effects of polystyrene nanoplastics on human neural stem cells

Cited by 2 publications

References 109 publications

The Hidden Health Crisis: Microplastics and Their Medical Consequences

The Hidden Health Crisis: Microplastics and Their Medical Consequences

From the Environment to Molecular Interactions of Nanoplastics: Unraveling the Neurotoxic Impacts and the Implications in Neurodegenerative Processes

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