Neurotoxic effects of subacute exposure of dichlorvos and methyl parathion at sublethal dosages in rats

Effect of propolis consumption on hepatotoxicity and brain damage in male rats exposed to chlorpyrifos

“…This is consistent with the study of Celik and Isik (2009). They reported that in animals intoxicated with methyl parathione and dichlorvos at sub lethal concentrations, AChE and butyl cholinesterase (BChE) activities are Newairy and Abdou 5239 inhibited.…”

The effect of exposure to chlorfenvinphos on lipid metabolism and apoptotic and necrotic cells death in the brain of rats

“…Neurotoxicity of OP compounds has been mainly explained by accumulation of acetylcholine, due to the inhibition of AChE and BChE activities, that produces cholinergic effects (Lotti, 2001;Darvesh et al, 2003;Celik and Isik, 2009;Sekar Babu et al, 2010;Li et al, 2011). Other pathways, including changes of the lipid profile of the nervous tissue as well as induction of apoptosis and necrosis of the nervous cells seem also to be involved (Brocardo et al, 2005;Üner et al, 2006;Kaur et al, 2007;El-Demerdash, 2011;Li et al, 2011;Solati et al, in press); however, up to now the non-cholinergic (non-cholinesterases-related) mechanisms have not been appropriately evaluated.…”

“…The impact of OP compounds on the nervous system was a subject of numerous studies (Lotti, 2001;Sekar Babu et al, 2010;Kaur et al, 2007;Celik and Isik, 2009;Li et al, 2011;Solati et al, in press); however, still there is a lack of investigations focused on the effect of low oral exposure, being the main route of human intoxication with these compounds during the lifetime, on the non-cholinergic pathway. The measurements performed in the present study draw attention to the involvement in the OP pesticides-induced CNS damage of the non-related to cholinesterases inhibition pathways such as destroying the brain lipid profile and reduction of the living brain cells due to their enhanced apoptosis and necrosis.…”

“…Although both enzymes are very useful biomarkers to estimate the damaging impact on the nervous system, AChE is still the mostly used indicator of exposure to OP pesticides in human (Lotti, 2001;Hernández et al, 2006;Singh et al, 2011) and experimental animals (Üner et al, 2006;Sekar Babu et al, 2010;Dwivedi and Flora, 2011;ElDemerdash, 2011). Some authors have determined BChE in the serum and various tissues under exposure to OP compounds (Celik and Isik, 2009;Karasova et al, 2009;Lajmanovich et al, 2009); however, only little data is available on the impact of these xenobiotics on the brain activity of this enzyme (Celik and Isik, 2009). The present study provides now and important data in this subject.…”

“…These compounds are known to damage to the different organs and systems at both acute and chronic exposure (Lasram et al, 2009;Singh et al, 2011;Dirican and Kalender, in press;Solati et al, in press); however, the main unfavorable effect of their action in mammals is the impact on the nervous system. Numerous experimental, epidemiological and clinical data show on the connection between exposure to OP pesticides and damage to the nervous system (Lotti, 2001;Sekar Babu et al, 2010;Kaur et al, 2007;Celik and Isik, 2009;Li et al, 2011;Solati et al, in press). The neurotoxic action of these compounds has been mainly explained by their ability to inhibit the activities of AChE and BChE.…”