Neurotensin immunoreactive neurons in the human infant diencephalon

Sakamoto, Noboru; Michel, Jean-Philippe; Kopp, Nicolas; Pearson, John

doi:10.1016/0006-8993(87)90119-3

Cited by 12 publications

(12 citation statements)

References 72 publications

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“…The high binding levels observed may be a consequence of the low levels of NT release and a compensatory up-regulation of receptors. In accordance of this, previous data report on the presence of relatively moderate amounts of NT immunoreactivity in human infant preoptic region, during the first postnatal month (Sakamoto et al, 1987). …”

Section: Discussionsupporting

confidence: 90%

“…Indeed, it has been shown in rat, that a blockade of neurotransmission for 5–9 days after the birth, with SR 48692 (NT antagonist), increases greatly the number of NT binding sites (Lépée-Lorgeoux et al, 1999). As previous studies reporting high and low amounts of endogenous NT in the human mammillary bodies of infant (Sakamoto et al, 1987) and adult (Langevin and Emson, 1982), respectively, one may speculate that endogenous NT levels would be responsible, at least in part, for the expression of NT binding, in the human hypothalamus, during peri- and postnatal phases. If in fact the reduced NT binding represents a physiologically relevant process, one plausible explanation would be that NT receptors in the hypothalamus during the postnatal period are down-regulated.…”

Section: Discussionmentioning

confidence: 61%

“…Taken together, it is tempting to postulate that the complex spatiotemporal pattern of NT binding sites expression in the developing hypothalamus in human, presumably results, at least partially, from the action of endogenous NT (Sakamoto et al, 1987) leading to an up or down regulation of NT receptors, as has been reported for rat brain (Palacios et al, 1988; Lépée-Lorgeoux et al, 2000). Nevertheless, and despite the well established modulatory role of the peptide on NT1 receptors in mature brain in rat (Azzi et al, 1996), it does not play a major role in establishing their developmental profile during the early postnatal period (Lépée-Lorgeoux et al, 2000).…”

Section: Discussionmentioning

confidence: 91%

“…Thus, intracerebroventricular or local NT injections in hypothalamus have been associated with dramatic alterations of the plasma levels of most anterior pituitary hormones (Alexander and Leeman, 1992; Vijayan et al, 1994; Rostène and Alexander, 1997; Sicard et al, 2005). Of interest, the hypothalamus, as reported in laboratory animals and human is especially enriched in endogenous peptide and NT receptors (Sarrieau et al, 1985; Kanba et al, 1986; Mai et al, 1987; Sakamoto et al, 1987; Rostène and Alexander, 1997; Najimi et al, 2014). The human hypothalamus is not completely mature at birth and its maturation continues during the postnatal period with relation to the maturation of peptidergic factors regulating pituitary function (Swaab, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Developmental aspects of neurotensinergic system in human hypothalamic–pituitary complex are scare and concerned particularly the endogenous NT in developing human hypothalamus (Sakamoto et al, 1987) and pituitary (Reyes et al, 2008). Developmental principles in NT and NT receptors have been extensively reported in laboratory animals notably in murine brain (Palacios et al, 1988; Sato et al, 1991, 1992; Lépée-Lorgeoux et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Developmental dynamics of neurotensin binding sites in the human hypothalamus during the first postnatal year

Najimi

Sarrieau

Kopp

et al. 2014

Front. Cell. Neurosci.

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The aim of the present study was to determine a detailed mapping of neurotensin (NT) in the human hypothalamus, during the first postnatal year using an in vitro quantitative autoradiography technique and the selective radioligand monoiodo-Tyr3-NT. Ten human postmortem hypothalami obtained from control neonates and infants (aged from 2 h to 1 year of postnatal age) were used. The biochemical kinetics of the binding in all obtained in this study revealed that the binding affinity constants were of high affinity (in the nanomolar range) and did not differ significantly between all cases investigated. Furthermore, competition experiments show insensitivity to levocabastine and were in favor of the presence of the high affinity site of NT receptor. Autoradiographic distribution showed that NT binding sites were widely distributed throughout the rostrocaudal extent of the hypothalamus. However, the distribution of NT binding sites was not homogenous and regional variations exist. In general, the highest densities were mainly present in the anterior hypothalamic level, particularly in the preoptic area. High NT binding site densities are also present at the mediobasal hypothalamic level, particularly in the paraventricular, parafornical, and dorsomedial nuclei. At the posterior level, low to very low densities could be observed in all the mammillary complex subdivisions, as well as the posterior hypothalamic area. Although this topographical distribution is almost identical during the postnatal period analyzed, age-related variations exist in discrete structures of the hypothalamus. The densities were higher in neonates/less aged infants than older infants in preoptic area (medial and lateral parts). The developmental profile is characterized by a progressive decrease from the neonate period to 1 year of postnatal age with a tendency to reach adult levels. On the other hand, the low levels of NT binding sites observed in posterior hypothalamus did not vary during the first postnatal year. They contrast in that with the very high levels we reported previously in adult. In conclusion, the present study demonstrates the occurrence of high NT binding sites density in various structures in many regions in the human neonate/infant hypothalamus, involved in the control of neuroendocrine and/or neurovegetative functions.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Developmental dynamics of neurotensin binding sites in the human hypothalamus during the first postnatal year

Najimi

Sarrieau

Kopp

et al. 2014

Front. Cell. Neurosci.

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Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter

2002

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This article reviews the current knowledge of the early onset of the monoaminergic innervation in the developing cerebral cortex in humans and of changes in the distribution of tyrosine hydroxylase (TH) immunoreactivity in different neuronal populations of the developing telencephalon. The early genesis of the central monoaminergic neurons in mammals has led to postulations of a trophic role of monoamines in brain morphogenesis-especially in the cerebral cortex. The developmental effects of amines can be linked to the transient expression of different molecules linked to dopamine or serotonin neurotransmission. We present novel data on the immunocytochemistry of the vesicular monoamine transporter (VMAT2) and of the high-affinity serotonin transporter (SERT) in human fetuses. SERT is a marker of the serotoninergic axons and allows visualization of the serotonin afferents of the raphe in the human telencephalon. In addition, during a restricted time period corresponding to 12-14 postovulatory weeks, we found SERT-immunolabeled fibers in the rostral and caudal limbs of the internal capsule that do not correspond to serotoninergic fibers, but do coincide with the calbindin D28k-labeled thalamocortical fiber tracts. The present observations are correlated with findings in rodents, in which a transient expression of SERT is visible in the thalamocortical axons during early postnatal life. The function of this transporter has been shown to be important for the fine-tuning of cortical sensory maps during the critical period of development of these maps. Although the present observation does not allow ascertainment of which neurons transiently express SERT, it lends support to the notion that serotonin and serotonin uptake could have important developmental roles, during the formation of brain connections in humans, as they have in rodents. Anat The early genesis of the central monoaminergic neurons in mammals has repeatedly led to postulations of a trophic role of monoamines on brain morphogenesis-especially in the cerebral cortex. Recent studies in rodents have allowed substantiation of these assumptions and have demonstrated that such an effect does occur in vivo. Indeed, modifying the levels of amines in the brain-in particular that of serotonin (5HT)-during critical periods affects the normal development of the somatosensory and visual maps (Rhoades et al., 1993;Bennett-Clarke et al.,

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Development of the human motor‐related thalamic nuclei during the first half of gestation, with special emphasis on GABAergic circuits

Kultas‐Ilinsky

Fallet

Verney

2004

J of Comparative Neurology

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This study analyzed the expression of differentiation markers (Calbindin D28K: CaBP; parvalbumin: PARV; calretinin: CalR), gamma-aminobutyric acid (GABA) markers (GABA, glutamic acid decarboxylases: GAD65, GAD67; and GABA transporters: GAT1, GAT3), and other markers (neurotensin: NT, and neurofilament-specific protein: SMI32) in the human thalamus at 8-23 gestation weeks (g.w.), focusing on the motor-related nuclei. From 8-13 g.w. mainly CaBP was expressed in the cells while fiber bundles traversing the thalamus in addition to CaBP expressed all GABA markers except GAD67. CaBP and PARV expression patterns in different nuclei changed over the time course studied, whereas NT was expressed consistently along the anterior-lateral curvature of the thalamus. CalR and SMI were detectable at 23 g.w. in the ventral parts of the dorsal thalamus. Most remarkably, punctate GAD65 immunoreactivity in the neuropil was confined to the nigro- and pallidothalamic afferent receiving nuclei from 16 to about 21 g.w., overlapping with that of CaBP in some of these nuclei (subdivisions of the ventral anterior and mediodorsal nuclei) and with PARV in others (centromedian nucleus). During this period, GAD65 immunoreactivity can be considered a marker of the basal ganglia afferent receiving territory in the motor thalamus. GAD67-positive local circuit neurons were first detected at 12-13 g.w. in the thalamic nuclei outside the basal ganglia afferent receiving territory. In the ventral anterior and centromedian nuclei, GAD-containing local circuit neurons were not conspicuous even at 22-23 g.w. The cells of the reticular nucleus expressed GAD67 and PARV from 12 g.w. on starting in the lateral-posterior regions. By 23 g.w., both markers were expressed in about two-thirds of the nucleus except for its most medial-anterior part. The results imply spatially and temporally differential expression of GABA and differentiation markers in the developing human thalamus.

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Neurotensin immunoreactive neurons in the human infant diencephalon

Cited by 12 publications

References 72 publications

Developmental dynamics of neurotensin binding sites in the human hypothalamus during the first postnatal year

Developmental dynamics of neurotensin binding sites in the human hypothalamus during the first postnatal year

Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter

Development of the human motor‐related thalamic nuclei during the first half of gestation, with special emphasis on GABAergic circuits

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