2014
DOI: 10.3389/fncel.2014.00251
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Developmental dynamics of neurotensin binding sites in the human hypothalamus during the first postnatal year

Abstract: The aim of the present study was to determine a detailed mapping of neurotensin (NT) in the human hypothalamus, during the first postnatal year using an in vitro quantitative autoradiography technique and the selective radioligand monoiodo-Tyr3-NT. Ten human postmortem hypothalami obtained from control neonates and infants (aged from 2 h to 1 year of postnatal age) were used. The biochemical kinetics of the binding in all obtained in this study revealed that the binding affinity constants were of high affinity… Show more

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Cited by 2 publications
(2 citation statements)
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“…The NT is a 13 amino acid neuropeptide that is produced in both the central nervous system and peripheral tissues, particularly in the small intestine . It participates in many vital biological functions including dopamine transmission, analgesia, hypothermia, etc. , The trace level detection of NT (pg/mL or lower levels in real samples) is clinically important to recognize subhealthy humans or initial-stage patients. , It has been known that GO is not only a carrier for electrochemiluminophores, but more importantly, it possesses excellent conductivity, which allows electrons to flow freely from the electrode to GO. In particular, capture antibody (Ab 1 ) modified ferroferric oxide nanoparticles/GO (Ab 1 -nanoFe 3 O 4 @GO) and detection antibody (Ab 2 ) modified N-(4-aminobutyl)-N-ethylisoluminol)/GO ((Ab 2 -ABEI)@GO) were used as the capture unit and detection unit in FCT-ECLIA, respectively (Figure ).…”
Section: Applicationsmentioning
confidence: 99%
See 1 more Smart Citation
“…The NT is a 13 amino acid neuropeptide that is produced in both the central nervous system and peripheral tissues, particularly in the small intestine . It participates in many vital biological functions including dopamine transmission, analgesia, hypothermia, etc. , The trace level detection of NT (pg/mL or lower levels in real samples) is clinically important to recognize subhealthy humans or initial-stage patients. , It has been known that GO is not only a carrier for electrochemiluminophores, but more importantly, it possesses excellent conductivity, which allows electrons to flow freely from the electrode to GO. In particular, capture antibody (Ab 1 ) modified ferroferric oxide nanoparticles/GO (Ab 1 -nanoFe 3 O 4 @GO) and detection antibody (Ab 2 ) modified N-(4-aminobutyl)-N-ethylisoluminol)/GO ((Ab 2 -ABEI)@GO) were used as the capture unit and detection unit in FCT-ECLIA, respectively (Figure ).…”
Section: Applicationsmentioning
confidence: 99%
“…52 It participates in many vital biological functions including dopamine transmission, analgesia, hypothermia, etc. 53,54 The trace level detection of NT (pg/mL or lower levels in real samples) is clinically important to recognize subhealthy humans or initial-stage patients. 55,56 It has been known that GO is not only a carrier for electrochemiluminophores, but more importantly, it possesses excellent conductivity, which allows electrons to flow freely from the electrode to GO.…”
Section: ■ Principlementioning
confidence: 99%