2020
DOI: 10.1016/j.bbrc.2020.07.087
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Olfactory marker protein elevates basal cAMP concentration

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Cited by 10 publications
(5 citation statements)
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“…OMP has been suspected for a long time to play a very important role in OSN maturation and OSN plasticity notably induced by external stimuli (Lee et al 2011;Kass et al 2013a). Astonishingly, a very recent study demonstrated that OMP was a cAMP buffer which was completely unexpected (Nakashima et al 2020). Similarly, future studies may reveal previously unknown roles for OSN response modulators.…”
Section: Discussionmentioning
confidence: 88%
“…OMP has been suspected for a long time to play a very important role in OSN maturation and OSN plasticity notably induced by external stimuli (Lee et al 2011;Kass et al 2013a). Astonishingly, a very recent study demonstrated that OMP was a cAMP buffer which was completely unexpected (Nakashima et al 2020). Similarly, future studies may reveal previously unknown roles for OSN response modulators.…”
Section: Discussionmentioning
confidence: 88%
“…These phenomena have been demonstrated to be caused by the increased overall basal activity due to the prolonged response of cAMP in Omp −/− mice in response to odorants 17 . Recent studies have reported that OMP directly binds cAMP to regulate the level of freely available cAMP and to control the basal cAMP pool 34 36 . Thus, by buffering the cAMP levels, OMP prevents persistent depolarization of OR neurons, enabling a sustained response to repeated stimuli.…”
Section: Discussionmentioning
confidence: 99%
“…Reporter gene expression protocol as previously described with a few modifications (Melnikov et al, 2014; Nakashima et al, 2020; Noack et al, 2022). Neuro2a cells were cultured at a density of 2.0 ×10 5 /well in 6-well plates transiently transfected with 1µg of plasmid/well, which included 500 ng of CREs-min.…”
Section: Methodsmentioning
confidence: 99%