Neuropsychomotor Development in Children and Adolescents With Liver Diseases: Systematic Review With Meta-Analysis

Santos, Juliana Costa; Saquetto, Micheli Bernardone; Neto, Mansueto Gomes; Santos, Josiane de Lima dos; Silva, Luciana Rodrígues

doi:10.1590/s0004-2803.202100000-40

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…those without chronic health conditions potentially impacting on the trajectory of development, 29 ). Evidence indicates that almost half of children with liver conditions require additional learning support at school 30 and preliminary findings indicate that cognition is poorer relative to the general population 31 . The skills needed for independent condition management may therefore develop later still in this population and may contribute to this finding.…”

Section: Discussionmentioning

confidence: 96%

Self‐management skills in a UK sample of young people with chronic liver disease

Day,

Hames,

Earl

et al. 2023

Pediatric Transplantation

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BackgroundWe aimed to assess self‐management skills and adherence behaviors in young people post‐liver transplant and compare these with those of young people with autoimmune liver disease and other forms of chronic liver disease.MethodAs part of our specialist multidisciplinary clinic, n = 156 young people (aged 16–25 years) completed the Liver Self‐Management Questionnaire (an adaptation of the Developmentally Based Skills Checklist for adolescents post‐liver transplant and modified for us across liver disease type and within the United Kingdom). Those taking medication (n = 128) also completed a service‐designed questionnaire regarding adherence. The statistical significance of group differences was assessed with non‐parametric analyses.ResultsYoung people post‐liver transplant were less likely to report managing their condition independently than those with autoimmune liver disease or those with other forms of chronic liver disease. They also reported higher adherence (93%) compared to those with autoimmune liver disease (77%) and those with other forms of chronic liver disease (85%). However, the vast majority of self‐management and adherence behaviors were comparable between young people post‐transplant and those with autoimmune liver disease/other forms of chronic liver disease.ConclusionOur data are in line with existing data from US samples and also extend these findings to include those with other forms of chronic liver disease. These data highlight the importance of individualized care for young adults, regardless of condition type or healthcare setting, and of clinicians managing their expectations regarding what is considered appropriate condition management in early adulthood.

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Section: Discussionmentioning

confidence: 96%

Self‐management skills in a UK sample of young people with chronic liver disease

Day,

Hames,

Earl

et al. 2023

Pediatric Transplantation

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Analysis of the odds ratio of developmental delay in children with biliary atresia 12 months after liver transplantation

Сыркина

Цирульникова

Pashkova

et al. 2021

RJTAO

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Background. Liver cirrhosis occurring before 1 year of age can affect a child’s development. Liver transplantation is the only radical treatment for decompensated cirrhosis. In biliary atresia, cirrhosis develops during the first months of life. The duration of cirrhosis in biliary atresia may vary from palliative Kasai portoenterostomy (PE) to liver transplantation. Developmental abnormalities in children with biliary atresia have been shown to occur both before and after liver transplantation. Association between duration of liver cirrhosis and psychomotor development of children has been underestimated.Objective: to determine the chances of developmental delay in children depending on the cirrhosis persistence duration.Materials and methods. The study enrolled 83 children with biliary atresia (47 children underwent palliative Kasai PE, 36 children with liver transplantation did not undergo Kasai PE). All children had their psychomotor development assessed before PE and 12 months after PE using the Griffiths psychomotor developmental scale (translation and adaptation by E.S. Keshishian) for children up to 24 months of age. Statistical analysis was performed by calculating odds ratios with 95% confidence intervals.Results. Comparative analysis showed that in the subgroup of children who underwent Kasai PE, cirrhosis persistence before transplantation was 2.6 months longer than in children without Kasai PE (p = 0.011). The odds of developmental delay in preparation for liver transplantation were 3.3 times higher in the subgroup of children who underwent Kasai palliative PE compared to children without palliative (95%, CI 1.35–8.31). The odds of developmental delay 12 months after liver transplantation were 4.4 times higher in the subgroup of children who underwent palliative Kasai PE than in children without the palliative care (95% CI 1.54–12.5).Conclusion. Children who underwent liver transplantation after palliative surgical treatment had lower levels of psychomotor development than children without palliative Kasai PE both before and 12 months after liver transplantation (p = 0.0018, p = 0.01 respectively).

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Neuropsychomotor Development in Children and Adolescents With Liver Diseases: Systematic Review With Meta-Analysis

Cited by 2 publications

References 33 publications

Self‐management skills in a UK sample of young people with chronic liver disease

Self‐management skills in a UK sample of young people with chronic liver disease

Analysis of the odds ratio of developmental delay in children with biliary atresia 12 months after liver transplantation

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