Neuropsychologicalassessment of frontotemporal dementia

Torralva, Teresa; Cuitiño, Macarena Martínez; Manes, Facundo

doi:10.1017/cbo9781316091586.012

Cited by 2 publications

(4 citation statements)

References 82 publications

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“…This highlights one main difficulty in identifying suitable tests for assessment. In this regard, reduced performance on tests sensitive to controlled inhibition, set-shifting and updating, is mainly associated with dorsolateral frontal dysfunction, whereas performance on others tasks sensitive to emotional/social cognition is mainly associated with frontotemporal dysfunction [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

et al. 2017

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Cognitive, behavioural, and functional assessment is crucial in longitudinal studies of neurodegenerative dementias (NDD). Central issues, such as the definition of the study population (asymptomatic, at risk, or individuals with dementia), the detection of change/decline, and the assessment of relevant outcomes depend on quantitative measures of cognitive, behavioural, and functional status.Currently, we are far from having available reliable protocols and tools for the assessment of dementias in Europe. The main problems are the heterogeneity of the tools used across different European countries, the lack of standardisation of administration and scoring methods across centres, and the limited information available about the psychometric properties of many tests currently in widespread use. This situation makes it hard to compare results across studies carried out in different centres, thus hampering research progress, in particular towards the contribution to a “big data” common data set.We present here the results of a project funded by the Joint Program for Neurodegenerative Diseases (JPND) and by the Italian Ministry of Health. The project aimed at providing a consensus framework for the harmonisation of assessment tools to be applied to research in neurodegenerative disorders affecting cognition across Europe. A panel of European experts reviewed the current methods of neuropsychological assessment, identified pending issues, and made recommendations for the harmonisation of neuropsychological assessment of neurodegenerative dementias in Europe.A consensus was achieved on the general recommendations to be followed in developing procedures and tools for neuropsychological assessment, with the aim of harmonising tools and procedures to achieve more reliable data on the cognitive-behavioural examination. The results of this study should be considered as a first step to enhancing a common view and practise on NDD assessment across European countries.

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Section: Resultsmentioning

confidence: 99%

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

et al. 2017

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“…The most frequent tests used to assess memory in FTD ( 82 ) are the Rey Auditory-Verbal Learning Test (RAVLT) ( 83 ) or similar word list-learning tests, such as the Hopkins Verbal Learning Test (HVLT-R) ( 84 ) or the California Verbal Learning Tests (CVLT) ( 85 ), the computerized Paired Associate Learning Test (PAL) ( 86 ), the Free and Cued Selective Reminding Test (FCSRT) ( 87 ), the autobiographical memory interview ( 88 ), and the Cambridge Behavioral Prospective Memory Test (CAMPROMPT) ( 89 ). These instruments are also commonly used in LAC [e.g., ( 52 , 90 )], although most of them are not validated for this population.…”

Section: Resultsmentioning

confidence: 99%

“…Tests of word comprehension, speech production (fluency, naming, and repetition), as well as oral reading (to detect surface dyslexia) and writing (to detect surface agraphia), should be used in the language assessment of FTD variants ( 82 ). The main instruments used for language assessment are the Boston Diagnostic Aphasia Examination (BDAE) ( 126 ) and the Sydney Language Battery (SYDBAT) ( 127 ).…”

Section: Resultsmentioning

confidence: 99%

“…Executive functions are defined as an umbrella concept, encompassing multiple functions commanded by the frontal lobe, such as planning, organization, sequencing, inhibitory control, and cognitive flexibility ( 154 , 155 ). In FTD, their assessment is of vital importance as it implies the involvement of the prefrontal cortex and some of its variants present a dysexecutive profile ( 82 , 156 ).…”

Section: Resultsmentioning

confidence: 99%

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Multidimensional Clinical Assessment in Frontotemporal Dementia and Its Spectrum in Latin America and the Caribbean: A Narrative Review and a Glance at Future Challenges

et al. 2022

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Frontotemporal dementia (FTD) is the third most common form of dementia across all age groups and is a leading cause of early-onset dementia. The Frontotemporal dementia (FTD) includes a spectrum of diseases that are classified according to their clinical presentation and patterns of neurodegeneration. There are two main types of FTD: behavioral FTD variant (bvFTD), characterized by a deterioration in social function, behavior, and personality; and primary progressive aphasias (PPA), characterized by a deficit in language skills. There are other types of FTD-related disorders that present motor impairment and/or parkinsonism, including FTD with motor neuron disease (FTD-MND), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS). The FTD and its associated disorders present great clinical heterogeneity. The diagnosis of FTD is based on the identification through clinical assessments of a specific clinical phenotype of impairments in different domains, complemented by an evaluation through instruments, i.e., tests and questionnaires, validated for the population under study, thus, achieving timely detection and treatment. While the prevalence of dementia in Latin America and the Caribbean (LAC) is increasing rapidly, there is still a lack of standardized instruments and consensus for FTD diagnosis. In this context, it is important to review the published tests and questionnaires adapted and/or validated in LAC for the assessment of cognition, behavior, functionality, and gait in FTD and its spectrum. Therefore, our paper has three main goals. First, to present a narrative review of the main tests and questionnaires published in LAC for the assessment of FTD and its spectrum in six dimensions: (i) Cognitive screening; (ii) Neuropsychological assessment divided by cognitive domain; (iii) Gait assessment; (iv) Behavioral and neuropsychiatric symptoms; (v) Functional assessment; and (vi) Global Rating Scale. Second, to propose a multidimensional clinical assessment of FTD in LAC identifying the main gaps. Lastly, it is proposed to create a LAC consortium that will discuss strategies to address the current challenges in the field.

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Neuropsychologicalassessment of frontotemporal dementia

Cited by 2 publications

References 82 publications

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

Multidimensional Clinical Assessment in Frontotemporal Dementia and Its Spectrum in Latin America and the Caribbean: A Narrative Review and a Glance at Future Challenges

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