Neuropsychological profiles of adults and older adults with HIV

Cassimjee, Nafisa; Motswai, Phenyo K

doi:10.1177/0081246316646296

Cited by 7 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study by Carvalhal et al patients who were started on antiretroviral therapy had better neuropsychological pro les than those were not on medication 39 Patients with neurocognitive impairment had low scores on the on tests assessing working memory, visuospatial abilities, verbal learning and memory. Cassimjee et al showed that participants with HIV had poorer performance pro les in global cognitive functioning, memory, executive functioning, visuoconstructional ability, psychomotor functioning, and processing speed 40 which are cognitive domains tested by the afore-mentioned tools.…”

Section: Discussionmentioning

confidence: 99%

Neurocognitive Dysfunction Among Patients Living With HIV/AIDS in a National Teaching Hospital in Ghana: Mixed Method Approach

Fiagbe

Boima

Ganu

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Studies have reported good therapeutic outcomes among persons living with HIV, however, there is evidence to indicate persisting cognitive deficits. The present study examined the pattern of neurocognitive deficits and psychosocial changes among persons living with HIV at a tertiary hospital in a Sub Saharan country, Ghana. Method This was facility-base cross-sectional study involving one hundred and twenty-three (123) patients recruited from an infectious disease unit in a national referral hospital. Structured questionnaire and standardized research instruments; Revised Quick Cognitive Screening Test (RQCST), Digit Span Test, Spatial Span Test, Cognitive Failure Questionnaire (CFQ), California Verbal Learning Test ii short form (CVLT), Santa Clara Strength of Religious (SCSR), Brief Symptom Inventory (BSI), WHO Quality of Life (WHOQOL) were used to obtain quantitative data on socio-demographic characteristics, cognitive function, spirituality, depression and quality of life. Eight individuals each were sampled for in-depth interviews. Responses were analyzed using interpretative phenomenological analysis (IPA). Statistical significance was set at < 0.05. Results The results indicated that 54% of the participants experienced cognitive deficits. There was a significant correlation between duration of the illness in months and Revised Quick Cognitive Screening Test [RQCST] Global score, r (73) = .29, p = .012, and Verbal score, r (73) = .35, p = .002 and Brief Symptoms Inventory [BSI] Depression sub-domain, r (61) = -.33, p = .009. Physical Health, a domain in WHO quality of life was a significant predictor of cognitive deficits in patient living with HIV/AIDS Conclusion Cognitive deficits are associated with poor psychosocial outcomes in patient living with HIV/AIDS, Neurocognitive assessment should be considered a crucial aspect in the management of HIV rehabilitation.

show abstract

Section: Discussionmentioning

confidence: 99%

Neurocognitive Dysfunction Among Patients Living With HIV/AIDS in a National Teaching Hospital in Ghana: Mixed Method Approach

Fiagbe

Boima

Ganu

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The existing literature examining performance on the Stroop in individuals living with HIV has shown mixed results. Some studies have shown similar performance on the Interference trial between HIV+ and HIVindividuals [2,15,16,17]. Others have found that individuals living with HIV perform signi cantly worse on the Interference trial than individuals who are HIV- [4,18,19].…”

Section: Introductionmentioning

confidence: 99%

“…Individuals living with HIV commonly demonstrate a neuropsychological pro le with prominent disturbances in executive functioning [1,2,3,4,5]. In addition to the cognitive impairment associated with HIV, there is a high rate of substance use disorders in the HIV population, making it di cult to determine which cognitive disturbances are due to HIV or illicit substances.…”

Section: Introductionmentioning

confidence: 99%

Specific Aspects of Executive Functioning Impacted in HIV and Cocaine Dependence

Nigro¹,

Wu²,

Lord³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Our study aimed to understand the effects of HIV and cocaine dependence (CD) on discrete aspects of executive functioning via the Stroop Color-Word Test and the Trail Making Test (TMT). We recruited 101 participants (26 HIV+/CD+; 18 HIV+/CD-; 30 HIV-/CD+; and 27 HIV-/CD-. Methods: We utilized a series of 2 (HIV: yes/no) × 2 (Cocaine: yes/no) ANCOVA’s while controlling for age and premorbid intelligence on the Stroop trials (i.e., color-naming, word reading, interference), and ANOVA’s were used to test for group differences on TMT-A and TMT-B z-scores, the number of errors, and the B/A ratio score. Results: We found a significant main effect of HIV on the Stroop Interference (p = 0.012) and the TMT B/A ratio (p = 0.017), these findings are consistent with difficulties in cognitive flexibility. On the Color-Naming and Interference trials, individuals with CD made significantly more errors than non-users (p = 0.028), demonstrating difficulties with inhibition. Conclusions: Our results show HIV and CD are associated with different underlying cognitive processes which impact overall executive functioning. Understanding the different cognitive factors impacting executive functioning can help formulate tailored treatment recommendations and targeted interventions for people living with HIV and those with cocaine dependence.

show abstract

The Association of Reproductive Aging with Cognitive Function in Sub-Saharan African Women

Jaff

Crowther

2021

Methods in Molecular Biology

View full text Add to dashboard Cite

Neuropsychological profiles of adults and older adults with HIV

Abstract: The wider availability of highly active anti-retroviral

Cited by 7 publications

References 37 publications

Neurocognitive Dysfunction Among Patients Living With HIV/AIDS in a National Teaching Hospital in Ghana: Mixed Method Approach

Neurocognitive Dysfunction Among Patients Living With HIV/AIDS in a National Teaching Hospital in Ghana: Mixed Method Approach

Specific Aspects of Executive Functioning Impacted in HIV and Cocaine Dependence

The Association of Reproductive Aging with Cognitive Function in Sub-Saharan African Women

Contact Info

Product

Resources

About