Neuropsychological impairment after hemorrhagic stroke in basal ganglia

Su, Chwen-Yng; Chen, Huimei; Kwan, Andy C.C.; Lin, Yueh Hsieh; Guo, Nai-Wen

doi:10.1016/j.acn.2007.01.025

Cited by 52 publications

(50 citation statements)

References 29 publications

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“…ICH most commonly occurs in the basal ganglia (striatum), and lesions there are reported to cause significant learning and memory deficits (Bhatia and Marsden, 1994;Hochstenbach et al, 1998;Su et al, 2007;Werring et al, 2004). Neuropsychological studies confirm the role of the striatum in cognition (Benke et al, 2003;El Massioui et al, 2007;Ragozzino, 2007;Sridharan et al, 2006), and ICH into the caudate putamen of rats produces a similar effect (Hartman et al, 2009).…”

mentioning

confidence: 61%

Protective Effect of Melatonin upon Neuropathology, Striatal Function, and Memory Ability after Intracerebral Hemorrhage in Rats

Lekic

Hartman

Rojas

et al. 2010

Journal of Neurotrauma

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Since free radicals play a role in the mechanisms of brain injury after hemorrhagic stroke, the effect of melatonin (a potent antioxidant and free-radical scavenger) on outcomes was investigated after intracerebral hemorrhage (ICH) in rats. ICH was induced by clostridial collagenase infusion into the right caudate putamen, and several time points and doses of melatonin were studied. Brain edema and neurological function at 24 h were unchanged in comparison with vehicle-treated groups, in spite of oxidative stress reductions. Repeated treatment with the lower dose of melatonin (5 mg=kg) given at 1 h and every 24 h thereafter for 3 days after ICH, led to normalization of striatal function and memory ability over the course of 8 weeks, and less brain atrophy 2 weeks later. These results suggest that melatonin is safe for use after ICH, reduces oxidative stress, provides brain protection, and could be used for future investigations of free radical mechanisms after cerebral hemorrhage.

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confidence: 61%

Protective Effect of Melatonin upon Neuropathology, Striatal Function, and Memory Ability after Intracerebral Hemorrhage in Rats

Lekic

Hartman

Rojas

et al. 2010

Journal of Neurotrauma

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“…Surveying cognitive deficits in patients with dorsal striatum lesions in fact reveals that the most common impairment is in explicit memory [88]–[90]. In functional neuroimaging studies, dorsal striatum is preferentially activated for learned relative to random motor sequences [91], for familiar items in an episodic recognition test [20], and while recalling recently-learned category membership [92], [93].…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Parkinson's Disease and Dopamine Replacement on Memory Encoding and Retrieval

et al. 2013

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Increasingly memory deficits are recognized in Parkinson's disease (PD). In PD, the dopamine-producing cells of the substantia nigra (SN) are significantly degenerated whereas those in the ventral tegmental area (VTA) are relatively spared. Dopamine-replacement medication improves cognitive processes that implicate the SN-innervated dorsal striatum but is thought to impair those that depend upon the VTA-supplied ventral striatum, limbic and prefrontal cortices. Our aim was to examine memory encoding and retrieval in PD and how they are affected by dopamine replacement. Twenty-nine PD patients performed the Rey Auditory Verbal Learning Test (RAVLT) and a non-verbal analogue, the Aggie Figures Learning Test (AFLT), both on and off dopaminergic medications. Twenty-seven, age-matched controls also performed these memory tests twice and their data were analyzed to correspond to the ON-OFF order of the PD patients to whom they were matched. We contrasted measures that emphasized with those that accentuated retrieval and investigated the effect of PD and dopamine-replacement on these processes separately. For PD patients relative to controls, encoding performance was normal in the off state and was impaired on dopaminergic medication. Retrieval was impaired off medication and improved by dopamine repletion. This pattern of findings suggests that VTA-innervated brain regions such as ventral striatum, limbic and prefrontal cortices are implicated in encoding, whereas the SN-supplied dorsal striatum mediates retrieval. Understanding this pattern of spared functions and deficits in PD, and the effect of dopamine replacement on these distinct memory processes, should prompt closer scrutiny of patients' cognitive complaints to inform titration of dopamine replacement dosages along with motor symptoms.

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“…Therefore, the typical clinical manifestations of PH include motor weakness, somatosensory deficit, homonymous hemianopsia, consciousness impairment, aphasia, and spatial neglect (Bogousslavsky and Caplan, 2001; Ghetti, 2012). By contrast, significantly fewer studies have reported on cognitive impairment in patients with PH (Hochstenbach et al, 1998; Shu et al, 2002; Su et al, 2007). In addition, little is known about the pathophysiological mechanisms of cognitive impairment in patients with PH (Yeo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Injury of the cingulum in patients with putaminal hemorrhage: a diffusion tensor tractography study

Kwon

Choi

Kim

et al. 2014

Front. Hum. Neurosci.

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Objectives: Little is known about the pathophysiological mechanisms of cognitive impairment in patients with putaminal hemorrhage (PH). Using diffusion tensor tractography, we investigated injury of the cingulum in patients with PH.Methods: We recruited 63 patients with PH, who were classified according to three groups, based on integrity of the cingulum to the lower portion of the genu of the corpus callosum: group A; preserved integrity, group B; discontinuation of integrity in the affected hemisphere, and group C; discontinuation of integrity in both hemispheres.Results: Thirty four patients (54.0%) belonged to group A, 16 patients (25.4%) to group B, and the remaining 13 patients (20.6%) to group C. Regarding the Mini-Mental State Examination, significant differences were observed between group A and group C, and between group B and group C without significant difference between group A and group B (p < 0.05). In terms of the volume of hematoma, significant differences were observed among the three groups (p < 0.05). Regarding the most anterior point of the hematoma, significant differences were observed between group A and groups B and C (p < 0.05); in contrast, regarding the most point of hematoma, significant differences were observed between group C and groups A and B, respectively (p < 0.05).Conclusion: We found that the anterior cingulum is vulnerable to PH. Therefore, our results suggest the necessity for evaluation of the cingulum in patients with PH particularly if the hematoma is large or close to the anterior margin or midline of the brain.

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Neuropsychological impairment after hemorrhagic stroke in basal ganglia

Cited by 52 publications

References 29 publications

Protective Effect of Melatonin upon Neuropathology, Striatal Function, and Memory Ability after Intracerebral Hemorrhage in Rats

Protective Effect of Melatonin upon Neuropathology, Striatal Function, and Memory Ability after Intracerebral Hemorrhage in Rats

Differential Effects of Parkinson's Disease and Dopamine Replacement on Memory Encoding and Retrieval

Injury of the cingulum in patients with putaminal hemorrhage: a diffusion tensor tractography study

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