Neuropsychiatric complications due to organ transplantation: a survey of 1499 Brazilian patients at a single center in São Paulo, Brazil

Marchiori, P E; Lino, Angelina Maria Martins; Britto, Nise; Bacchella, Telésforo; Machado, Marcel Cerqueira César; Mies, Sérgio; Massarollo, Paulo Celso Bosco; Scaff, Milberto

doi:10.1016/j.trre.2005.06.002

Cited by 5 publications

(3 citation statements)

References 51 publications

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“…Neurologic complications in such patients are influenced by their primary disease and prior cardiovascular and CNS status, the surgical procedure and postoperative course, and post‐transplant medication. The most common complication is ischemic stroke, reported in 3–10% of the patients [5,6,9–11], followed by drug toxicity. Valve disease as the reason for the transplant is associated with ischemic stroke; diabetes mellitus and renal failure are associated with seizures [10].…”

Section: Organ‐specific Neurologic Complicationsmentioning

confidence: 99%

“…Central nervous system complications after kidney transplantation are reported in 6–21% of recipients [9,23]. Stroke may occur in 8% of renal transplant recipients and may be facilitated by hypertension, diabetes and accelerated atherosclerosis, which may be acquired during dialysis or after transplantation [74].…”

Section: Organ‐specific Neurologic Complicationsmentioning

confidence: 99%

“…Neurologic complications of liver transplantation are more common than other solid organ transplants, ranging from 4% to 70% in the published series [2,9,15–21]. Living donor liver transplantation is associated with a significantly lower incidence of neurologic complications than in patients who receive a cadaveric graft [19].…”

Section: Organ‐specific Neurologic Complicationsmentioning

confidence: 99%

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Neurologic complications after solid organ transplantation

Senzolo

Ferronato

Burra

2009

Transplant International

166

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Summary Neurologic complications are common after solid organ transplantation and are associated with significant morbidity. Approximately one‐third of transplant recipients experiences neurologic alterations with incidence ranging from 10% to 59%. The complications can be divided into such of those common to all types of transplant and others of those specific to transplanted organ. The most common complication seen with all types of transplanted organ is neurotoxicity attributable to immunosuppressive drugs, followed by seizures, opportunistic central nervous system (CNS) infections, cardiovascular events, encephalopathy and de novo CNS neoplasms. Amongst immunosuppressants, calcineurin inhibitors are the main drugs involved in neurotoxicity, leading to complications which ranges from mild symptoms, such as tremors and paresthesia to severe symptoms, such as disabling pain syndrome and leukoencephalopathy. Neurologic complications of liver transplantation are more common than that of other solid organ transplants (13–47%); encephalopathy is the most common CNS complication, followed by seizures; however, central pontine myelinolysis can appear in 1–8% of the patients leading to permanent disabilities or death. In kidney transplanted patients, stroke is the most common neurologic complication, whereas cerebral infarction and bleeding are more typical after heart transplantation. Metabolic, electrolyte and infectious anomalies represent common risk factors; however, identification of specific causes and early diagnosis are still difficult, because of patient’s poor clinical status and concomitant systemic and metabolic disorders, which may obscure symptoms.

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Section: Organ‐specific Neurologic Complicationsmentioning

confidence: 99%

Section: Organ‐specific Neurologic Complicationsmentioning

confidence: 99%