Neuropsychiatric aspects of COVID-19 pandemic: A selective review

Dinakaran, Damodharan; Manjunatha, Narayana; Kumar, Channaveerachari Naveen; Babburi, Suresh

doi:10.1016/j.ajp.2020.102188

Cited by 97 publications

(93 citation statements)

References 61 publications

(72 reference statements)

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“…It is also seen that the involvement of SARS-CoV-2 with neurological aspects can affect different levels of the Central and Peripheral Nervous System, in addition to causing skeletal-muscular injury, representing 36.4% of the cases considered, including impairment of consciousness, ataxia, acute cerebrovascular disease, seizure and neuropathic pain, for example ( Bilbul et al, 2020 ). In an epidemiologically deeper approach, Dinakaran et al (2020) reinforces a percentage value close to the one reported by Bilbul et al (2020) regarding the neurological complaints of COVID-19 patients: 36%.…”

Section: Disorders and Epidemiological Profilessupporting

confidence: 77%

“…The COVID-19 takes, thereby, a pandemic feature, whose landmark is its effects on the respiratory system and its more serious manifestation: the Severe Acute Respiratory Syndrome ( Troyer et al, 2020 .). Due to the ability to generate multiple infections to systemic organs ( Jasti et al, 2020 ), the referred virus can cause damage to the kidneys, heart, liver and brain, for example ( Dinakaran et al, 2020 ). From a neurological perspective, individuals affected by the virus have reported headache, dizziness, hypogeusia and hyposmia during the course of the disease, with intensive care patients being more likely to complain of dizziness ( Zhou et al, 2020 ).…”

Section: Disorders and Epidemiological Profilesmentioning

confidence: 99%

“…However, an increased prevalence of antibodies against four strains of HCoV in patients with a recent episode psychosis compared with non-psychiatric controls was found, suggesting a possible relationship between infections and psychosis, which may also occur with the SARS-CoV-2 ( Troyer et al, 2020 ). Evidences suggest that 0.9 to 4% of individuals infected with SARS-CoV-2 develop psychotic spectrum disorders ( Dinakaran et al, 2020 ).…”

Section: Main Repercussionsmentioning

confidence: 99%

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The psychiatric and neuropsychiatric repercussions associated with severe infections of COVID-19 and other coronaviruses

Moreira

Barbosa

Vieira

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Introduction It is known that viral infections are epidemiologically prevalent and some of them are harmful to the central nervous system (CNS) due to the development of neuropsychiatric syndromes which affect the cognitive, affective, behavioral and perceptual domains. Objective To carry out a comprehensive analysis of the psychiatric and neuropsychiatric repercussions of COVID-19 based on epidemiological, pathophysiological and clinical foundations observed in previous and recent pandemic events, and also to make a proposition about effective therapeutic interventions to help tackle this serious public health problem, more specifically in its neuropsychiatric developments. Method This current literature review has utilized literature reserves and scientific search engines MEDLINE, EMBASE and Web of Science. The search terms included, “SARS-CoV-2”, “etiology,” “psychiatric and neuropsychiatric repercussions”, “severe infections” “COVID-19”. Specific choices of unique papers from each of the searches were identified. The inclusion criteria were relevance and availability of full-text. Papers were excluded on the basis of relevance and non-availability of full-text. Papers were identified in the general literature reserve as pertinent to the search terms. Results The main psychiatric and neuropsychiatric repercussions analyzed were depression, anxiety, post-traumatic stress disorder, psychosis, nonspecific neurological symptoms, delirium, cerebrovascular complications, encephalopathies, neuromuscular disorders, anosmia and ageusia. Conclusion The psychiatric and neuropsychiatric symptoms of acute respiratory syndromes can appear during or after the infectious stage. Among the risk factors pointed out for such effects are the female gender, health professionals, presence of avascular necrosis and distressing pain.

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Section: Disorders and Epidemiological Profilessupporting

confidence: 77%

Section: Disorders and Epidemiological Profilesmentioning

confidence: 99%

Section: Main Repercussionsmentioning

confidence: 99%

See 1 more Smart Citation

The psychiatric and neuropsychiatric repercussions associated with severe infections of COVID-19 and other coronaviruses

Moreira

Barbosa

Vieira

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Manifestations such as insomnia, anxiety, post-traumatic stress symptoms (PTSD), psychosis and mood disorders have been described in several reports (see Table 1; Dinakaran et al, 2020;Liguori et al, 2020;Nalleballe et al, 2020;Rogers et al, 2020;Romero-Sanchez et al, 2020;Vindegaard and Benros, 2020). A study that retrieved data from a global health collaborative platform that included medical records of 40,469 COVID-19 positive cases, mostly from the United States (US) (76%), found that 22.5% had neurological and/or psychiatric manifestations, being anxiety and related disorders the most prevalent (4.6%) (Nalleballe et al, 2020).…”

Section: Neuropsychiatric Manifestations Of Covid-19mentioning

confidence: 99%

Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia

Alonso‐Lana

Marquié

Ruiz

et al. 2020

Front. Aging Neurosci.

147

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The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide and has had unprecedented effects in healthcare systems, economies and society. COVID-19 clinical presentation primarily affects the respiratory system causing bilateral pneumonia, but it is increasingly being recognized as a systemic disease, with neurologic manifestations reported in patients with mild symptoms but, most frequently, in those in a severe condition. Elderly individuals are at high risk of developing severe forms of COVID-19 due to factors associated with aging and a higher prevalence of medical comorbidities and, therefore, they are more vulnerable to possible lasting neuropsychiatric and cognitive impairments. Several reports have described insomnia, depressed mood, anxiety, post-traumatic stress disorder and cognitive impairment in a proportion of patients after discharge from the hospital. The potential mechanisms underlying these symptoms are not fully understood but are probably multifactorial, involving direct neurotrophic effect of SARS-CoV-2, consequences of long intensive care unit stays, the use of mechanical ventilation and sedative drugs, brain hypoxia, systemic inflammation, secondary effects of medications used to treat COVID-19 and dysfunction of peripheral organs. Chronic diseases such as dementia are a particular concern not only because they are associated with higher rates of hospitalization and mortality but also because COVID-19 further exacerbates the vulnerability of those with cognitive impairment. In patients with dementia, COVID-19 frequently has an atypical presentation with mental status changes complicating the early identification of cases. COVID-19 has had a dramatical impact in long-term care facilities, where rates of infection and mortality have been very high. Community measures implemented to slow the spread of the virus have forced to social distancing and cancelation of cognitive stimulation programs, which may have contributed to generate loneliness, behavioral symptoms and worsening of cognition in patients with dementia. COVID-19 has impacted the functioning of Memory Clinics, research programs and clinical trials in the Alzheimer's field, triggering the

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“…A more realistic approach of study from the participants of the rst infection-affected area of hospitals in Wuhan showed more convincing metal-health states. Of all participants of health care workers especially nurses, women reported health and mental burden and those were undergone diagnosis management and treatment [34,35]. The present situation has affected different frontiers of lives and induced many psychiatric conditions in large number of individuals.…”

Section: Discussionmentioning

confidence: 99%

Pre-infection global psychosocial status on SARS CoV-2 disease outcome

Sinha

Maiti

2020

Preprint

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The present pandemic situation due to Covid-19 disease has raised a severe threat on human health both physically and mentally. Globally, 794,435 persons were died from a total 22,767,009. We assumed that existed psychosocial-conditions in the pre-infection-period have a great role in disease pathogenesis-severity. This might have geographically/regionally influenced different parameters of the disease. The present aim was to delineate the impact of pre-infection or post-infection psychosocial impact on Covid-19 outcome. Existing global mental-status (depression-anxiety, economic-status, quality-of-life/QOL, Global-Health-Security/GHS, tobacco-smoking and suicide-mortality were verified with their possible correlation with the total-infection/death-rate/case-fatality-rate(CFR) analyzed in >170 countries. The data was collected from World-Health-Organization/World-Bank/United-Nations, and the Johns-Hopkins-Center for Health-Security. The SPSS/version-16.0 was utilized for student’s t test, multivariate-ANOVA, Correlation and Prediction for numerical-outcomes, Linear-regression. Pearson’s-chi-square-test was performed in the current study. Psychological wellbeing like happiness-GSH-QOL, mental-impairments like depression-anxiety have been variably-positively correlated with total-confirmed-infection-cases, total-death and CFR (p<0.05-p<0.001). Happiness has been positively associated with QOL/GSH/anxiety-depressive-disorder. Higher CFR has been noticed more in the developed countries. Virus-host interactions may have some variability depending on the race-ethnicity-and individual’s-body-compositions. Because, this study has been done >170 countries, the present outcome is important. The positive correlation between happiness-QOL index with the apparent adverse outcome of Covid-19 and the correlation between happiness/QOL with anxiety-depression disorder are found to be parallel. This suggests more characterizations of these psychosocial-indices are needed. The open-minded nations with non-conserved nature which eventuates to more transportation, tourist trafficking and more social association/collaborations, that might have affected more. Further studies are necessary in this regard.

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Neuropsychiatric aspects of COVID-19 pandemic: A selective review

Cited by 97 publications

References 61 publications

The psychiatric and neuropsychiatric repercussions associated with severe infections of COVID-19 and other coronaviruses

The psychiatric and neuropsychiatric repercussions associated with severe infections of COVID-19 and other coronaviruses

Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia

Pre-infection global psychosocial status on SARS CoV-2 disease outcome

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