Neuroprotective role of Ginkgo biloba against cognitive deficits associated with Bisphenol A exposure: An animal model study

Tabaa, Manar Mohammed El; Sokkar, Samia Salem; Ramadan, Ehab Sayed; Salam, Inas Zakria Abd El; Anis, Anis

doi:10.1016/j.neuint.2017.03.019

Cited by 27 publications

(18 citation statements)

References 67 publications

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“…55 In the present study, administration of BPA caused a marked prolongation in the escape latency in the daily training trials and a decrease in the time spent in the target quadrant of MWM test, as well as a decline in the discrimination index of NOR test, which indicated impairment in acquisition and retention of spatial memory and cognition deficits. These results were in accordance with El Tabaa et al 56 In addition, a previous study reported that BPA impaired object recognition in adult male rats by blocking synaptic plasticity processes in the hippocampus. 57 It has been reported that BDNF plays a critical role in memory consolidation.…”

Section: Discussionsupporting

confidence: 92%

Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats

Morsy

Ahmed

2020

Hum Exp Toxicol

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Bisphenol A (BPA) is used to produce polycarbonate plastic and epoxy resins which are used in many consumer products. Most people encounter BPA in their daily routines. However, it has been heavily reported that BPA has a neurotoxic effect. The present study aimed to investigate the effect of lycopene on cognitive deficits induced by a high dose of BPA focusing on mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway, oxidative stress, apoptosis, and memory retrieval in adult male rats. Therefore, 72 rats were divided into four groups: control group, BPA group (50 mg/kg body weight (bw)) 3 days a week for 42 days, lycopene group (10 mg/kg bw) daily for 42 days, and lycopene + BPA group. Concurrent treatment of lycopene with BPA improved the learning and cognition memory in Morris water maze and novel object recognition tests along with an increase in acetylcholine esterase activity as well as inhibition of oxidative stress by restoring reduced glutathione and suppressing malondialdehyde hippocampal level to their normal levels. Mechanistically, lycopene upregulated the protein expression of tyrosine receptor kinase B, which resulted in an upsurge in its downstream cascades MAPK/ERK1/2/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus of BPA-intoxicated rats. Furthermore, concurrent treatment of lycopene with BPA prevented apoptosis by marked decrease in Bcl-2 associated X protein (Bax) gene expression and caspase 3 activity while restoring B-cell leukemia/lymphoma-2 (Bcl-2) gene expression. In conclusion, the present study provided evidence that lycopene exerted a neuroprotective effect against BPA intoxication in hippocampi of rats via its antioxidant properties, activation of MAPK/ERK pathway, and inhibiting a neuronal apoptosis which reflected on improving the learning and cognition memory.

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Section: Discussionsupporting

confidence: 92%

Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats

Morsy

Ahmed

2020

Hum Exp Toxicol

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“…As a neurotoxic agent, BPA mainly affects hippocampal neurogenesis and causes cognitive impairment in animal models (Castro et al, 2013; Tiwari et al, 2016; El Tabaa et al, 2017). Various studies have reported that BPA affects glutamate receptors (NMDARs and AMPARs) and produces neurotoxicity (Xu X. et al, 2010; Xu X.H.…”

Section: Glutamate Receptors As Potential Targets In Neurotoxic Agentmentioning

confidence: 99%

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

Jakaria

Park

Haque

et al. 2018

Front. Mol. Neurosci.

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Glutamate receptors play a crucial role in the central nervous system and are implicated in different brain disorders. They play a significant role in the pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Although many studies on NDDs have been conducted, their exact pathophysiological characteristics are still not fully understood. In in vivo and in vitro models of neurotoxic-induced NDDs, neurotoxic agents are used to induce several neuronal injuries for the purpose of correlating them with the pathological characteristics of NDDs. Moreover, therapeutic drugs might be discovered based on the studies employing these models. In NDD models, different neurotoxic agents, namely, kainic acid, domoic acid, glutamate, β-N-Methylamino-L-alanine, amyloid beta, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 1-methyl-4-phenylpyridinium, rotenone, 3-Nitropropionic acid and methamphetamine can potently impair both ionotropic and metabotropic glutamate receptors, leading to the progression of toxicity. Many other neurotoxic agents mainly affect the functions of ionotropic glutamate receptors. We discuss particular neurotoxic agents that can act upon glutamate receptors so as to effectively mimic NDDs. The correlation of neurotoxic agent-induced disease characteristics with glutamate receptors would aid the discovery and development of therapeutic drugs for NDDs.

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“…Several preclinical and clinical studies have demonstrated the effectiveness of BS, ZO and GB extracts in varied animal models of memory impairment (Ebrahimpour et al, 2017;El Tabaa et al, 2017;Kim et al, 2018). However, none have examined the combinational effects of these three substances on memory functions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Boswellia serrata, Zingiber officinale and Ginkgo biloba extracts in combination on memory impairment in mice

Moradian¹,

Dinani²,

Sharifabad³

et al. 2021

J. Med. Plants Res.

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Cognitive decline induced by oxidative brain damage is the critical pathological hallmark of Alzheimer's disease. Studies have shown that individual administration of Boswellia serrata Roxb (BS), Zingiber officinale Roscoe (ZO) and Ginkgo biloba L. (GB) extracts improved memory and learning through a different mechanism of actions. This study aims to compare the individual effects of each extract with their co-administration on memory impairment induced by scopolamine in mice. Memory dysfunction was induced by a single dose of scopolamine (1 mg/kg, i.p) and extracts were administered intraperitoneally in different doses for one week. Memory performance of the mice was evaluated using the object recognition task (ORT) and passive avoidance test (PAT). The outcomes from ORT demonstrated that, ZO and GB extracts at 200 mg/kg and BS extract just in combination group significantly enhanced (by 95%) the memory loss induced by scopolamine (P < 0.05). On the other hand, PAT results revealed that BS extract at 60 and 90 mg/kg, ZO and GB extracts at 200 mg/kg and their combinations noticeably improved the latency time (by 80%). Although in PAT, co-administration of extracts was more effective than either alone doses in augmenting of the memory function, ORT results showed no considerable differences.

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Neuroprotective role of Ginkgo biloba against cognitive deficits associated with Bisphenol A exposure: An animal model study

Cited by 27 publications

References 67 publications

Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats

Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

Effects of Boswellia serrata, Zingiber officinale and Ginkgo biloba extracts in combination on memory impairment in mice

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