Neuroprotective potential of Beta vulgaris L. in Parkinson′s disease

Nade, Vandana S; Kawale, Laxman A; Zambre, Shankar S; Kapure, Amit B

doi:10.4103/0253-7613.161263

Cited by 22 publications

(22 citation statements)

References 16 publications

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“…In rodents, repeated administration of reserpine induces motor impairments (e.g., catalepsy, increased oral movements, and decreased locomotor activity) accompanied by cognitive deficits. As a result, this monoamine depleting agent is used to model both Parkinson’s disease and tardive dyskinesia ( Abilio et al, 2002 , 2004 ; Silva et al, 2002 ; Carvalho et al, 2006 ; Fernandes et al, 2012 ; Santos et al, 2013 ; Leao et al, 2015 ; Nade et al, 2015 ; de Freitas et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

et al. 2016

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Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson’s disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of reserpine in rodents induces motor impairments that are accompanied by cognitive deficits, and has been applied to model both tardive dyskinesia and Parkinson’s disease. The present study investigated whether CBD administration would attenuate reserpine-induced motor and cognitive impairments in rats. Male Wistar rats received four injections of CBD (0.5 or 5 mg/kg) or vehicle (days 2–5). On days 3 and 5, animals received also one injection of 1 mg/kg reserpine or vehicle. Locomotor activity, vacuous chewing movements, and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated animals’ performance on the plus-maze discriminative avoidance task, for learning/memory assessment. CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements – but not the decrease in locomotion – induced by reserpine. CBD (0.5 mg/kg) also ameliorated the reserpine-induced memory deficit in the discriminative avoidance task. Our data show that CBD is able to attenuate motor and cognitive impairments induced by reserpine, suggesting the use of this compound in the pharmacotherapy of Parkinson’s disease and tardive dyskinesia.

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Section: Introductionmentioning

confidence: 99%

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

et al. 2016

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“…Haloperidol (1 mg/kg) was injected intraperitoneally for 21 d to induce catalepsy and tardive dyskinesia [21]. The test drugs and vehicles were given orally for 21 d, one hour before haloperidol injection.…”

Section: Experimental Designmentioning

confidence: 99%

“…Group-III (standard) was treated with L-Dopa, carbidopa combination (30 mg/kg)+Haloperidol [21] Group IV and V animals (test groups) received the methanolic extract of Sargassum wightii at the doses of 200 and 400 mg/kg respectively and were co-administered with Haloperidol (ip) Then all the rats were subjected to behavioral and biochemical assessments. On the 22 nd day, following behavioral assessment, the animals were sacrificed by cervical dislocation.…”

Section: Group-ii (Disease Control) Received 1% Cmc+haloperidolmentioning

confidence: 99%

Neuroprotective Effect of Methanolic Extract of Sargassum Wightii on Haloperidol Induced Catalepsy and Tardive Dyskinesia in Albino Rats

Rout

Rath

Bhattamisra

et al. 2020

Int J Pharm Pharm Sci

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Objective: The present study was designed to evaluate the neuroprotective effect of methanolic extract of Sargassum wightii on haloperidolinduced catalepsy and tardive dyskinesia in Wistar albino rats. Methods:In this study, thirty Wistar albino rats were randomly divided into six groups. Gr-I served as control. Haloperidol (1 mg/kg intraperitoneally) was administered to rats of Gr-II to Gr-V for twenty-one consecutive days to induce catalepsy and tardive dyskinesia. Animals of Gr-II to Gr-V were orally administered with vehicle, levodopa carbidopa combination (30 mg/kg), Sargassum extract 200 and 400 mg/kg respectively. All the drugs and vehicles were given orally one hour before haloperidol injection for twenty one consecutive days. The cataleptic scores were recorded using standard bar test. Tardive dyskinesia was assessed in terms of vacuous chewing movement (VCM) and tongue protrusion (TP) scores. After behavioural testing, all animals were sacrificed on twenty-second day and various biochemical parameters like MDA, SOD and GSH were estimated in brain tissue.Results: Chronic administration of haloperidol significantly increased cataleptic scores, VCM and TP scores. (p<0.001) Sargassum wightii extract (400 mg/kg) significantly inhibited haloperidol-induced catalepsy, VCM and TP (p<0.001) Haloperidol increased MDA and decreased SOD and GSH in brain tissue to a highly significant extent (p<0.001) Sargassum extract at 400 mg/kg also significantly reversed the haloperidol-induced alteration in brain oxidative stress markers. Conclusion:Sargassum wightii inhibits haloperidol-induced catalepsy and tardive dyskinesia. Thus it may be used as a unique therapeutic adjunct for the prevention of neuroleptic-induced extrapyramidal symptoms, however, it has to be explored more.

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“…Bradykinesia was assessed by holding the rat's tail and placing the front paws on a platform and letting the animal walk. The number of steps taken with the forelimbs for 3 minutes was counted [18].…”

Section: Test For Bradykinesiamentioning

confidence: 99%

Investigating the Effects of Tolcapone a Catechol-O-Methyltransferase Inhibitor on Learning and Memory in Passive Avoidance Task

Bakova

Zlatanova

Doncheva

et al. 2019

JAMMR

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Aim: The aim of the present study was to evaluate the effects of tolcapone in haloperidolchallenged rodent models of learning and memory and reserpine-induced parkinsonism in rats. Methods: The learning and memory enhancing effects of tolcapone (TCP) were assessed in male Wistar rats treated with 5, 15 and 30 mg/kg bw, p.o. The impact of tolcapone on haloperidol challenge and reserpine induced parkinsonism was studied in rodents treated with 5,15 and 30 mg/kg bw TCP p.o. Step-through passive avoidance and loco-motor activity were assessed. The latency reaction time and the number of horizontal and vertical movements were registered, respectively. Statistical analysis was done by SPSS Statistics 19.

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Neuroprotective potential of Beta vulgaris L. in Parkinson′s disease

Cited by 22 publications

References 16 publications

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

Neuroprotective Effect of Methanolic Extract of Sargassum Wightii on Haloperidol Induced Catalepsy and Tardive Dyskinesia in Albino Rats

Investigating the Effects of Tolcapone a Catechol-O-Methyltransferase Inhibitor on Learning and Memory in Passive Avoidance Task

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