Investigating the Effects of Tolcapone a Catechol-O-Methyltransferase Inhibitor on Learning and Memory in Passive Avoidance Task

Abstract

Aim: The aim of the present study was to evaluate the effects of tolcapone in haloperidolchallenged rodent models of learning and memory and reserpine-induced parkinsonism in rats. Methods: The learning and memory enhancing effects of tolcapone (TCP) were assessed in male Wistar rats treated with 5, 15 and 30 mg/kg bw, p.o. The impact of tolcapone on haloperidol challenge and reserpine induced parkinsonism was studied in rodents treated with 5,15 and 30 mg/kg bw TCP p.o. Step-through passive avoidance and loco-motor activity were assessed. The latency reaction time and the number of horizontal and vertical movements were registered, respectively. Statistical analysis was done by SPSS Statistics 19.