Neuroprotective phosphatidylserine liposomes alleviate depressive-like behavior related to stroke through neuroinflammation attenuation in the mouse hippocampus

Partoazar, Alireza; Seyyedian, Zahra; Zamanian, Golnaz; Saffari, Partow Mirzaee; Muhammadnejad, Ahad; Dehpour, Ahmad Reza; Goudarzi, Ramin

doi:10.1007/s00213-021-05783-1

Cited by 20 publications

(17 citation statements)

References 39 publications

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“…In animal models, PS administration reduced the immobility time in the forced swimming test in mice, implicating the significant antidepressant effect of PS ( Castilho et al, 2004 ). Treatment post-stroke depressive mice with PS liposomes significantly reduced the immobility time in the forced swimming test and tail suspension test ( Partoazar et al, 2021 ). In addition, intracerebroventricular injection of PS also attenuated stress-induced behaviors in chick isolation-induced stress model ( Koutoku et al, 2005 ).…”

Section: The Roles Of Phosphatidylserine In Different Central Nervous...mentioning

confidence: 99%

“…Other studies have reported that PS treatment inhibits the production of ACTH, reduces the production of plasma cortisol, and 10.3389/fnagi.2022.975176 then slows down the activation of the hypothalamus-pituitaryadrenal (HPA) axis in the process of MDD (Monteleone et al, 1992;Hellhammer et al, 2004;More et al, 2014). Although PS alleviated depressive behaviors in post-stroke depression mice through the reduction of pro-inflammatory cytokines such as TNF-α (Partoazar et al, 2021); the blood contents of IL1β, TNF-α, and IL6 did not alter in elderly patients with MDD after PS supplementation (Brambilla and Maggioni, 1998). Therefore, whether PS functions as an antidepressant through anti-inflammatory needs further studies or not.…”

Section: Major Depressive Disordermentioning

confidence: 99%

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Phosphatidylserine, inflammation, and central nervous system diseases

Wang

et al. 2022

Front. Aging Neurosci.

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Phosphatidylserine (PS) is an anionic phospholipid in the eukaryotic membrane and is abundant in the brain. Accumulated studies have revealed that PS is involved in the multiple functions of the brain, such as activation of membrane signaling pathways, neuroinflammation, neurotransmission, and synaptic refinement. Those functions of PS are related to central nervous system (CNS) diseases. In this review, we discuss the metabolism of PS, the anti-inflammation function of PS in the brain; the alterations of PS in different CNS diseases, and the possibility of PS to serve as a therapeutic agent for diseases. Clinical studies have showed that PS has no side effects and is well tolerated. Therefore, PS and PS liposome could be a promising supplementation for these neurodegenerative and neurodevelopmental diseases.

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Section: The Roles Of Phosphatidylserine In Different Central Nervous...mentioning

confidence: 99%

Section: Major Depressive Disordermentioning

confidence: 99%

Phosphatidylserine, inflammation, and central nervous system diseases

Wang

et al. 2022

Front. Aging Neurosci.

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“…Ceramide is the key metabolite of sphingomyelin metabolism. Its biological functions primarily include inducing apoptosis ( Toshima et al, 2019 ; Partoazar et al, 2021 ), regulating cell differentiation ( Naeini et al, 2021 ), regulating cellular immunity, and participating in regulating inflammatory response ( Aragón-Aranda et al, 2021 ). Our results revealed that berberine could significantly decrease LysoPC levels, which indicated that berberine could significantly prevent LPS-induced systemic inflammation by regulating the abnormal phospholipid metabolic pathway.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts by regulating the LPS-induced apoptosis signaling pathway

Zhang

Guo²,

Wei³

et al. 2022

Front. Pharmacol.

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This article examines berberine’s biological effects and molecular mechanisms with an inflammatory response model induced by lipopolysaccharide (LPS) in human gingival fibroblasts (HGFs) using metabolomics. The viability of HGFs was determined using the cell counting kit-8 (CCK8). ELISA was used to measure inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor- α (TNF-α). An investigation of western blots was conducted to investigate the related proteins of apoptosis. Low concentrations of berberine (0.1, 0.5, and 1 μmol L−1) did not affect HGF growth, whereas high concentrations of berberine (5–25 μmol L−1) significantly activated cell proliferation. Berberine suppressed the elevated secretion of IL-6, IL-1β, and TNF-α induced by LPS in HGF. Western blot analysis showed that 10 μmol L−1 of berberine significantly inhibited LPS-induced apoptosis signaling pathway activation. Our results suggested that berberine could inhibit LPS-induced apoptosis and the production of proinflammatory mediators in HGFs cells. Berberine may be a potential therapeutic drug for the management of periodontitis.

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“…All slides were analyzed in a blinded fashion by an expert pathologist and cytokines level of brain samples were scored as follows: negative (0–1), weak (2–3), moderate (4–6), and severe (7–8). The presence of brown cells in the stained sections indicated the expression of the relative cytokine markers [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Beneficial effects of ROCEN (Topical Nano-arthrocen) on atopic dermatitis in mice

Goudarzi¹,

Eskandarynasab

Muhammadnejad

et al. 2021

BMC Complement Med Ther

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Objective Atopic dermatitis (AD) is a chronic inflammatory skin disease mainly caused by immune stimuli. The current study was conducted to investigate the effects of ROCEN and to compare it with betamethasone (Beta) on mice subjected to AD. Methods First, the safety of topical ROCEN was tested to determine possible sensitization induction in vivo. Then, the mice were subjected to oxazolone (Oxa) to induce chronic AD. Consequently, they underwent treatment with ROCEN and Beta. Scratching and wiping behaviors related to dermatitis were evaluated in treated animals for 35 days. The histopathology and immunohistochemistry (IHC) analysis of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) cytokines were performed on the dorsal skin of the treated mice. Results Topical administration of ROCEN and Beta to the dorsum of sensitized mice for 5 weeks significantly alleviated scratching and wiping symptoms and reduced erythema, scaling, and edema in the skin of the mice with AD. Moreover, histological indices showed that ROCEN effectively reduced leucocyte infiltration and improved skin healing parameters in treated AD mice. Application of ROCEN or Beta reduced IHC markers including IL-8 and TNF-α significantly. Conclusion ROCEN alleviated the AD symptoms similar to betamethasone in an experimental animal model.

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Neuroprotective phosphatidylserine liposomes alleviate depressive-like behavior related to stroke through neuroinflammation attenuation in the mouse hippocampus

Cited by 20 publications

References 39 publications

Phosphatidylserine, inflammation, and central nervous system diseases

Phosphatidylserine, inflammation, and central nervous system diseases

Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts by regulating the LPS-induced apoptosis signaling pathway

Beneficial effects of ROCEN (Topical Nano-arthrocen) on atopic dermatitis in mice

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