Neuroprotective phenolics in medicinal plants

Abstract

Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, ischemia and traumatic injury are characterized by progressive neuronal loss and dysfunction. Many neuroprotective agents modulating cellular responses against noxious stimuli, such as oxidative stresses, thereby having anti-inflammatory and antiapoptotic activity have been studied to develop the therapeutics for neurodegenerative diseases. Recently, the phenolic compounds widely spread in medicinal plants have drawn attention as potential neuroprotective agents. In this review, naturally-occurring neuroprotective phenolics and their underlying mechanisms of neuroprotective actions are summarized.

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated fromRhus vernicifluain LPS-stimulated BV2 Microglial Cells

“…Ester derivatives of caffeic acid also exhibit various biological activities [20]. For example, caffeic acid phenylethyl ester (CAPE), an antioxidant component of propolis, protects against glutamate-induced neurotoxicity [21] and cerebral ischemia [22].…”

The Influence of Pre‐ and Postharvest Environmental Stress on Fruit Bioactives

“…In humans, plant phenolics are also thought to function as antioxidants and it has been suggested that a diet high in plant phenolics can reduce the accumulation of free radicals and peroxides, which may cause oxidative damage to macromolecules such as DNA, lipids and proteins (Heim et al, 2002). Oxidative damage has been linked to aging, atherosclerosis, cancer, inflammation and neurodegenerative disorders, and it has been suggested that the consumption of plant phenolics could help reduce susceptibility to these diseases/disorders (Burton-Freeman, 2010;Dai and Mumper, 2010;Kim, 2010;Tsao, 2010). However, the data regarding the absorption and bioavailability of dietary phenolics in humans are still controversial (de Oliveira and Bastos, 2011).…”

Substituent effects on the electrocatalytic oxidation of phenols at preanodized screen-printed carbon electrodes

“…Phenols are a group of molecules with important biological properties, such as anti-inflammatory, antibacterial, and antioxidant properties [1,2]. In addition, these compounds are common organic pollutants with high toxicities found in the waste effluents of industrial processes and agricultural activities.…”