Neuroprotective lifestyles and the aging brain

Gow, Alan J.; Bastin, Mark E.; Maniega, Susana Muñoz; Hernández, Maria C. Valdés; Morris, Zoë; Murray, Catherine; Royle, Natalie A.; Starr, John M.; Deary, Ian J.; Wardlaw, Joanna M.

doi:10.1212/wnl.0b013e3182703fd2

Cited by 171 publications

(173 citation statements)

References 37 publications

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“…95 The brain renin-angiotensin II system and hypertension in SHR are reported to be attenuated by exercise, 96 which preserves small vessel function and is associated with fewer WMH. 97 Angiotensin receptor blockers and exercise are also expected to improve large artery remodeling. 98 Thus, the recent advancement in the understanding of SVD risk factors and related molecular pathways from animal and human studies may provide clues in the search for potential remedies for SVD (Figure 3).…”

Section: Future Perspectives In the Treatment Of Svdmentioning

confidence: 99%

Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease

Ihara

Yamamoto

2016

Stroke

120

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Section: Future Perspectives In the Treatment Of Svdmentioning

confidence: 99%

Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease

Ihara

Yamamoto

2016

Stroke

120

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“…Research in the past decade has identified some factors that modulate the decline and enhance its integrity in healthy older adults, including physical exercise (Fleischman et al, 2015;Gow et al, 2012;Sen et al, 2012), cognitive activities (Wirth, Haase, Villeneuve, Vogel, & Jagust, 2014), and complex leisure activities (Saczynski et al, 2008). In one study, older adults who participated in a life-long high volume and high-intensity exercise training showed a significant 83% reduction in deep white matter lesions and a 44% reduction in total white matter hyperintensities volume relative to their sedentary counterparts.…”

Section: Wml and White Matter Plasticitymentioning

confidence: 99%

Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Lam

Yiend

Lee

2017

NRE

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“…9,10 Both animal and human studies 11 suggest that the benefit of physical activity on brain health in aging may be at least partially attributable to enhancement of blood flow, angiogenesis, and maintenance of the cerebral vasculature 12 and a concomitant reduction of WMH burden. 13 These studies suggest that higher levels of physical activity in older adults may provide some degree of protection from the untoward consequences of accumulating brain pathology on motor function in older age.…”

mentioning

confidence: 92%

Physical activity, motor function, and white matter hyperintensity burden in healthy older adults

et al. 2015

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Objective: To test the hypothesis that physical activity modifies the association between white matter hyperintensity (WMH) burden and motor function in healthy older persons without dementia.Methods: Total daily activity (exercise and nonexercise physical activity) was measured for up to 11 days with actigraphy (Actical; Philips Respironics, Bend, OR) in 167 older adults without dementia participating in the Rush Memory and Aging Project. Eleven motor performances were summarized into a previously described global motor score. WMH volume was expressed as percent of intracranial volume. Linear regression models, adjusted for age, education, and sex, were performed with total WMH volume as the predictor and global motor score as the outcome. Terms for total daily physical activity and its interaction with WMH volume were then added to the model. Results:Higher WMH burden was associated with lower motor function (p 5 0.006), and total daily activity was positively associated with motor function (p 5 0.002). Total daily activity modified the association between WMH and motor function (p 5 0.007). WMH burden was not associated with motor function in persons with high activity (90th percentile). By contrast, higher WMH burden remained associated with lower motor function in persons with average (50th percentile; estimate 5 20.304, slope 5 20.133) and low (10th percentile; estimate 5 21.793, slope 5 20.241) activity. Conclusions:Higher levels of physical activity may reduce the effect of WMH burden on motor function in healthy older adults. Neurology ® 2015;84:1294-1300 GLOSSARY BDNF 5 brain-derived neurotrophic factor; BMI 5 body mass index; FLAIR 5 fluid-attenuated inversion recovery; MPRAGE 5 magnetization-prepared rapid-acquisition gradient echo; WMH 5 white matter hyperintensity.Late life motor impairment is common in older adults and associated with a wide range of adverse health outcomes.

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Neuroprotective lifestyles and the aging brain

Abstract: In this large, narrow-age sample of adults in their 70s, physical activity was associated with less atrophy and WML. Its role as a potential neuroprotective factor is supported; however, the direction of causation is unclear from this observational study.

Cited by 171 publications

References 37 publications

Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease

Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease

Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Physical activity, motor function, and white matter hyperintensity burden in healthy older adults

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