Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Lam, Charlene L.M.; Yiend, Jenny; Lee, Tatia M.C.

doi:10.3233/nre-171471

Cited by 12 publications

(12 citation statements)

References 51 publications

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“…The conclusion drawn is that the ability to control a situation declines when task requirements increase and this is particularly obvious in older adults. This finding seems to corroborate those of previous studies suggesting significant age-related effects on the combined application of inhibition and switching ( Bryan and Luszcz, 2000 ; Plumet et al, 2005 ; Adornetti, 2016 ; Lam et al, 2017 ).…”

Section: Discussionsupporting

confidence: 92%

“…Inversely, increased performance under switching recruitment (number of words generated) of older adults with RVD reflects that there is no such severe decline in set-shifting ability in this group, compared to VaD patients. On the other hand, the higher performance of young adults in the same condition compared to older adults with RVD, may indicate a progressive decline in cognitive flexibility along with age as well as its corresponding health deterioration ( Bryan and Luszcz, 2000 ; Gunning-Dixon and Raz, 2003 ; Plumet et al, 2005 ; Spiro and Brady, 2008 ; Adornetti, 2016 ; Lam et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies argue that there is an increase in interference and a decline in switching in people with severe white matter lesions ( Lam et al, 2017 ). According to the findings of the same systematic review and meta-analysis study, ( Sudo et al, 2017 ) which examined inhibitory control measured by the Stroop test, the decline of cognitive flexibility, as measured by the Trail Making Test – B in small vessel disease, also represents a specific EF deficit that might be attributed to the increased vulnerability to interlobar disconnection due to periventricular white matter hyperintensities.…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory Control, Task/Rule Switching, and Cognitive Planning in Vascular Dementia: Are There Any Differences From Vascular Aging?

Pantsiou

Sfakianaki

Papaliagkas

et al. 2018

Front. Aging Neurosci.

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Recent studies have shown that patients diagnosed with Vascular Dementia (VaD) exhibit deficits in executive functions. According to “vascular hypothesis of cognitive aging,” community-dwelling older adults having risk factors for vascular disease development (RVD) may suffer from cognitive decline of the same type. The aim of the study was to assess the level of specific executive functions (EF) that have been revealed as most affected by vascular abnormalities, in older adults with incipient VaD and RVD. Subsequently specific ways of EF measuring could be suggested for more accurate diagnosis of early stage VaD. The study compared three adult groups (N = 60): (a) patients diagnosed with incipient VaD, according to DSM-5 criteria (n = 20); (b) community-dwelling older adults presenting cardiovascular risk factors (RVD; n = 20); (c) healthy young adult controls (n = 20). Three types of executive functions were examined: inhibitory control, cognitive flexibility as rule/task switching, and planning. The following D-KEFS subtests were administered for their evaluation: The ‘Color-Word Interference Test,’ the ‘Verbal Fluency Test,’ and the ‘Tower Test.’ Mixed-measures ANOVA, MANOVA, and one-way ANOVA as well as Scheffe post hoc test were applied to the data of the scores in each condition of each test. The results showed that VaD patients had significantly lower performance in test conditions requiring switching and planning, compared to RVD group and young controls. The specific deficits of VaD patients, compared to older adults presenting RVD according to multiple-group path analyses were: more uncorrected errors in inhibition, the use of semantic knowledge primarily instead of switching ability to switch between semantic categories, as well as a lower level of movement precision in planning.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Inhibitory Control, Task/Rule Switching, and Cognitive Planning in Vascular Dementia: Are There Any Differences From Vascular Aging?

Pantsiou

Sfakianaki

Papaliagkas

et al. 2018

Front. Aging Neurosci.

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“…Besides the fact that no studies exist to report cognitive flexibility deficits in people with SCD, cognitive control difficulties are usually presented in older adults as a result of a degree of vascular abnormality. Specifically, there are indications that older adults with risk factors for vascular disease development present lower performance compared to young adults in inhibitory control and inhibition plus switching [72,75,76]. Our study comes to contribute by also supporting the idea that cognitive flexibility deficits exist in older adults with SCD, since ICT/RST-S3 is sensitive enough to detect them.…”

Section: Ict/rst-s3 Differential Abilitysupporting

confidence: 74%

Is the Discrimination of Subjective Cognitive Decline from Cognitively Healthy Adulthood and Mild Cognitive Impairment Possible? A Pilot Study Utilizing the R4Alz Battery

Poptsi

Μoraitou

Tsardoulias

et al. 2020

JAD

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Background: The early diagnosis of neurocognitive disorders before the symptoms’ onset is the ultimate goal of the scientific community. REMEDES for Alzheimer (R4Alz) is a battery, designed for assessing cognitive control abilities in people with minor and major neurocognitive disorders. Objective: To investigate whether the R4Alz battery’s tasks differentiate subjective cognitive decline (SCD) from cognitively healthy adults (CHA) and mild cognitive impairment (MCI). Methods: The R4Alz battery was administered to 175 Greek adults, categorized in five groups a) healthy young adults (HYA; n = 42), b) healthy middle-aged adults (HMaA; n = 33), c) healthy older adults (HOA; n = 14), d) community-dwelling older adults with SCD (n = 34), and e) people with MCI (n = 52). Results: Between the seven R4Alz subtasks, four showcased the best results for differentiating HOA from SCD: the working memory updating (WMCUT-S3), the inhibition and switching subtask (ICT/RST-S1&S2), the failure sets (FS) of the ICT/RST-S1&S2, and the cognitive flexibility subtask (ICT/RST-S3). The total score of the four R4Alz subtasks (R4AlzTot4) leads to an excellent discrimination among SCD and healthy adulthood, and to fare discrimination among SCD and MCI. Conclusion: The R4Alz battery is a novel approach regarding the neuropsychological assessment of people with SCD, since it can very well assist toward discriminating SCD from HOA. The R4Alz is able to measure decline of specific cognitive control abilities - namely of working memory updating, and complex executive functions - which seem to be the neuropsychological substrate of cognitive complaints in community dwelling adults of advancing age.

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“…Neuroimaging studies have shown that WMH may cause a frontal-subcortical pathway disruption, leading to executive, attentional, and processing speed impairment19–21 as well as memory deficits, due to retrieval impairment 17,22,23. WMH have been observed in amnestic and nonamnestic subtypes of MCI 15,17,24,25…”

Section: Introductionmentioning

confidence: 99%

Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities

Djabelkhir-Jemmi¹,

Wu²,

Boubaya³

et al. 2018

CIA

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ObjectiveThis study aimed to explore whether a computerized cognitive stimulation program (CCS) induced differential effects in older adults with mild cognitive impairment (MCI) according to the severity of white matter hyperintensities (WMH), which are associated with cognitive impairment and increased risk of progression to Alzheimer’s disease because of the damage they cause to cortical and subcortical networks.Patients and methodsTwenty-nine MCI patients with no or little WMH (MCI-non-WMH) and 22 MCI patients with moderate or severe WMH (MCI-WMH) attended a 24-session CCS program (two sessions per week for a duration of 3 months) focused on executive functions, attention, and processing speed. Cognitive and psychosocial assessments were performed at baseline, postintervention, and 3 months after the intervention.ResultsBoth groups improved on several cognitive measures after the intervention. However, the MCI-non-WMH group improved on a higher number of cognitive measures than the MCI-WMH group. At postintervention assessment, CCS had a more beneficial effect on the MCI-non-WMH group than on the MCI-WMH group with regard to improving categorical fluency (4.6±6.8 vs 0.4±6.4; effect size=0.37; p=0.002). During the 3-month follow-up assessment, significantly higher score improvements were observed in the MCI-non-WMH group for the paired-associate learning test (6.4±3 vs 4.7±3.5 points; effect size=0.43; p=0.005) as well as categorical fluency (3.8±7.8 vs −0.7±6 points; effect size=0.55; p=0.0003).ConclusionsThese findings suggest that WMH severity was related to cognitive improvement induced by a CCS program and highlight the importance of considering WMH in interventional studies on subjects with MCI.

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Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Abstract: BACKGROUND: White matter lesions (WML) are prevalent in older adults. The association

Cited by 12 publications

References 51 publications

Inhibitory Control, Task/Rule Switching, and Cognitive Planning in Vascular Dementia: Are There Any Differences From Vascular Aging?

Inhibitory Control, Task/Rule Switching, and Cognitive Planning in Vascular Dementia: Are There Any Differences From Vascular Aging?

Is the Discrimination of Subjective Cognitive Decline from Cognitively Healthy Adulthood and Mild Cognitive Impairment Possible? A Pilot Study Utilizing the R4Alz Battery

Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities

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