Neuroprotective effects of nitrone radical scavenger S-PBN on reperfusion nerve injury in rats

Gray, Chris; Nukada, Hitoshi; Jackson, David M.; McMorran, P. Denise; Wu, A.; Ma, Fang

doi:10.1016/s0006-8993(03)03006-3

Cited by 10 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nitrone based free radical scavengers have demonstrated potent neuroprotection in stroke models in which oxidative . stress plays a key role (25 of neuroprotection from nitrones is unknown, but current research suggests two major hypotheses: 1) mass-action free radical trapping; and 2) inhibition of enhanced signal transduction associated with neuroin flammatory processes.…”

Section: Alpha-phenyl-n-tert-butylnitrone (Pbn)mentioning

confidence: 99%

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

Montcalm-Smith¹,

Fahlman²,

Kayar³

2008

asem

View full text Add to dashboard Cite

show abstract

Section: Alpha-phenyl-n-tert-butylnitrone (Pbn)mentioning

confidence: 99%

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

Montcalm-Smith¹,

Fahlman²,

Kayar³

2008

asem

View full text Add to dashboard Cite

show abstract

“…Ischemia plays an important role in the production and development of pathological changes in various neuropathies including peripheral neuropathy particularly sciatic nerve [1][2][3]. Pathophysiology ischemia-reperfusion is platelet aggregation, oxygen free radicals and the interaction between endothelial cells and leukocytes [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Pathophysiology ischemia-reperfusion is platelet aggregation, oxygen free radicals and the interaction between endothelial cells and leukocytes [1][2][3]. This phenomenon leads to endothelial damage, capillary occlusion and deficiency of oxygen reaching to neural tissue [1][2][3]. Many efforts have occurred to reduce the effects of ischemia-reperfusion injury.…”

Section: Introductionmentioning

confidence: 99%

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

Zendedel

Delavari

Ahmadvand

et al. 2015

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: Selenium is an antioxidant trace element that is capable protects various tissues against damage induced by ischemiareperfusion injury. Objectives: This study examines the selenium effect on antioxidant activity and recovery from sciatic nerve ischemia-reperfusion in adult rats. Materials and Methods:In this experimental study, 80 adult male Wistar rats weighing 250 -300 g were used. They were divided into ten groups (n = 8 per group). The first group received sham surgery only. The second group received 0.2 mg/kg selenium without ischemiareperfusion surgery and eight remaining groups were divided to four control groups and four experimental groups which the latter groups received 0.2 mg/kg selenium. All ischemia groups were rendered in ischemic for 3 hours and reperfused for various times of 3, 7, 14 and 28 days. Half of the groups had experimental selenium (0.2 mg/kg) intraperitoneal injection treatment immediately after ischemia. According to a schedule for each group of rats bled and then centrifuged, and serum was prepared for assessment of activity levels of glutathione peroxidase (GPX), catalase (CAT), nitric oxide (NO), paraoxonase (POX), and malondialdehyde (MDA). Results: Comparison of the serum GPX, CAT, NO, POX, and MDA levels in the groups that received selenium with corresponding control group showed that selenium can increase plasma activity levels of GPX, POX and decrease activity levels of NO. Conclusions: Selenium with decreased activity levels of NO and increased activity GPX and POX can decrease ischemia-reperfusion injury in lower limb especially sciatic nerve.

show abstract

“…Grey et al examined the effects of 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) on reperfusion damage occurring in rat peripheral nerves and found that postischemic applications of S-PBN could have important neuroprotective characteristics on I/R nerve damage (32). After examining mRNA expressions of the pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) following I/R damage in rat sciatic and tibial nerve fibers, Mitsui et al reported that TNF-α and IL-1-β mRNA expressions were correlated with the ischemic damage on their own, and they were even more significantly associated with reperfusion than ischemia itself (33).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Resveratrol in a Rat Model of Ischemia-Reperfusion Injury of Sciatic Nerve

2017

GMJ

View full text Add to dashboard Cite

Objective: The aim of this study was to determine the effects of resveratrol on ischemia-reperfusion (I/R) injury in the rats sciatic nerve. Methods: We used 18 Wistar rats anesthetized with ketamine (50 mg/kg-im). In the sham group, we only performed the surgery and not administer any medication. In the ischemia group, we generated I/R injury in 5 minute intervals with medical treatment of saline only. In the resveratrol group, we brought about the same I/R injury but gave resveratrol before the surgery by per oral. After sacrifice, we studied blood and nerve tissue samples. We evaluated the damage with malondialdehyde (MDA), nitric oxide (NO), and total antioxidant capacity (TAC), both in tissue and blood. Results: Evaluation of serum levels of antioxidant markers and tissue samples demonstrated statistically significant effects of resveratrol in ischemiareperfusion injury. Conclusion: This study revealed the antioxidant effect of resveratrol as an inhibitor of lipid peroxidation.

show abstract

Neuroprotective effects of nitrone radical scavenger S-PBN on reperfusion nerve injury in rats

Cited by 10 publications

References 31 publications

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

Protective Effects of Resveratrol in a Rat Model of Ischemia-Reperfusion Injury of Sciatic Nerve

Contact Info

Product

Resources

About