Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats

Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Erbaş, Oytun; Taşkıran, Dilek

doi:10.1080/01480545.2021.1914464

Cited by 7 publications

(3 citation statements)

References 55 publications

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“…When the literature is examined, it is seen that there is a limited number of studies showing that DXP may have antiinflammatory and neuroprotective effects 6,11,12,24,26,37) . This situation reveals the originality of our study.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Neuroprotective Efficacy of Dexpanthenol in an Experimental Head Injury Model

Karatoprak,

Engin,

Sahin

et al. 2024

J Korean Neurosurg Soc

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Objective : Dexpanthenol (DXP), which has known neuroprotective effects, has been shown to be beneficial in various experimental models and ischaemic diseases. The aim of this study was to investigate the possible neuroprotective effects of DXP in a traumatic brain injury (TBI) model. Methods : Thirty-six Wistar-Albino female rats, approximately 6 months old, weighing 220-285 g were used. All rats were subjected to closed head trauma by dropping a weight of 350 g on the parietal region from a height of 50 cm at an angle of 180 degrees in the prepared head trauma model setup. The rats were divided into four groups as control (group 1), trauma (group 2), trauma + DXP (group 3), and DXP (group 4). In group 3, DXP was administered intraperitoneally at a dose of 500 mg/kg for six times at 30 minutes, 6, 12, 24, 36, and 48 hours. In group 4, DXP was administered intraperitoneally simultaneously with group 3 without causing head trauma. Blood samples were taken from all rats 72 hours later for biochemical examination. After blood samples were taken, rats were decapitated under general anaesthesia. Cerebral tissue samples were taken from decapitated rats for immunohistochemical and histopathological examination. Results : Cytokine markers were found to be increased in posttraumatic brain tissue. Malondialdehyde and glutathione reductase levels were lower in group 3 compared to group 2. In addition, superoxide dismutase, glutathione peroxidase and catalase levels were significantly higher in group 3 compared to group 2. In histological evaluation, congestion in the piamater layer, cell infiltration, vascular congestion, hemorrhage and neuronal degeneration were significantly decreased in group 3 compared to group 2. DXP seems to be beneficial in neurological recovery in terms of histological and oxidative changes after head trauma in rats. Conclusion : DXP should be further evaluated for its possible therapeutic effect in TBI.

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Section: Discussionmentioning

confidence: 99%

Investigation of Neuroprotective Efficacy of Dexpanthenol in an Experimental Head Injury Model

Karatoprak,

Engin,

Sahin

et al. 2024

J Korean Neurosurg Soc

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show abstract

“…Dexpanthenol's antioxidant activity has been associated with improved levels of amino acid neurotransmitters which play significant roles in energy metabolism [35] . Dexpanthenol treatment given after streptozotocin-induced memory deficit was shown to ameliorate inflammation, and to preserve cognitive functions by restoring cholinergic system neu-rons [16] . Dexpanthenol's recently-discovered neuroprotective activity gives hope for its use in clinical practice as an easily accessible and affordable treatment for neuroinflammation.…”

Section: Discussionmentioning

confidence: 99%

“…It is water soluble [11] and has antioxidant, anti-inflammatory, antiapoptotic, and neuroprotective activities [11][12][13][14] . Dexpanthenol has been shown to protect brain tissue against oxidative damage and apoptosis in a neuroinflammation model [15] and to protect against streptozotocin-induced neuronal damage [16] . In a cerebral ischemia and reperfusion model, dexpanthenol has exerted potent antioxidant activity and was found to be neuroprotective [14] .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and neuroprotective effects of dexpanthenol in rats induced with traumatic brain injury

Bektaşoğlu¹,

Koyuncuoğlu²,

Demir³

et al. 2023

Injury

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Dexpanthenol ameliorates doxorubicin-induced lung injury by regulating endoplasmic reticulum stress and apoptosis

Tepebaşı

Büyükbayram

Özmen

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats

Cited by 7 publications

References 55 publications

Investigation of Neuroprotective Efficacy of Dexpanthenol in an Experimental Head Injury Model

Investigation of Neuroprotective Efficacy of Dexpanthenol in an Experimental Head Injury Model

Antioxidant and neuroprotective effects of dexpanthenol in rats induced with traumatic brain injury

Dexpanthenol ameliorates doxorubicin-induced lung injury by regulating endoplasmic reticulum stress and apoptosis

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