Dexpanthenol ameliorates doxorubicin-induced lung injury by regulating endoplasmic reticulum stress and apoptosis

Tepebaşı, Muhammet Yusuf; Büyükbayram, Halil İbrahim; Özmen, Özlem; Ağirca, Şerife; SELÇUK, Esma

doi:10.1007/s00210-023-02497-3

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…No significant tissue damage was detected in any of the organs except for the lungs among the tested groups. In the DOX group, lung tissues displayed increased septal tissue thickness and infiltration of inflammatory cells. , In comparison, the control group exhibited reduced lung injury compared to both the DOX group and the DOX@UiO-66-NH 2 NPs group. It is important to acknowledge that despite the use of intratumoral injection in this study, some degree of tissue organ damage was still observed in mice after 14 days of treatment.…”

Section: Resultsmentioning

confidence: 99%

Amino-Functionalized Zirconium-Based Metal–Organic Frameworks as Bifunctional Nanomaterials to Treat Bone Tumors and Promote Osteogenesis

Yuan,

Zeng,

Pan

et al. 2023

ACS Appl. Mater. Interfaces

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Bone tumor patients often encounter challenges associated with cancer cell residues and bone defects postoperation. To address this, there is an urgent need to develop a material that can enable tumor treatment and promote bone repair. Metal–organic frameworks (MOFs) have attracted the interest of many researchers due to their special porous structure, which has great potential in regenerative medicine and drug delivery. However, few studies explore MOFs with dual antitumor and bone regeneration properties. In this study, we investigated amino-functionalized zirconium-based MOF nanoparticles (UiO-66-NH2 NPs) as bifunctional nanomaterials for bone tumor treatment and osteogenesis promotion. UiO-66-NH2 NPs loading with doxorubicin (DOX) (DOX@UiO-66-NH2 NPs) showed good antitumor efficacy both in vitro and in vivo. Additionally, DOX@UiO-66-NH2 NPs significantly reduced lung injury compared to free DOX in vivo. Interestingly, the internalized UiO-66-NH2 NPs notably promoted the osteogenic differentiation of preosteoblasts. RNA-sequencing data revealed that PI3K-Akt signaling pathways or MAPK signaling pathways might be involved in this enhanced osteogenesis. Overall, UiO-66-NH2 NPs exhibit dual functionality in tumor treatment and bone repair, making them highly promising as a bifunctional material with broad application prospects.

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Section: Resultsmentioning

confidence: 99%

Amino-Functionalized Zirconium-Based Metal–Organic Frameworks as Bifunctional Nanomaterials to Treat Bone Tumors and Promote Osteogenesis

Yuan,

Zeng,

Pan

et al. 2023

ACS Appl. Mater. Interfaces

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“…All groups had ad libitum access to food during the 8‐week study period. Rats in the study groups were administered intraperitoneal injections of 500 mg/kg/day of DEX (Bayer) [ 19,28 ] and/or 0.5 mg/kg‐day of nicotine (liquid form, N‐3876; Sigma). The administration of nicotine and/or DEX was concurrent within their respective groups.…”

Section: Methodsmentioning

confidence: 99%

Dexpanthenol exhibits antiapoptotic and anti‐inflammatory effects against nicotine‐induced liver damage by modulating Bax/Bcl‐xL, Caspase‐3/9, and Akt/NF‐κB pathways

Üremiş,

Aslan,

Taşlidere

et al. 2024

J Biochem & Molecular Tox

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Chronic tobacco use can lead to liver damage and inflammation due to the accumulation of various toxins in the body. This study aimed to investigate the correlation between the molecular mechanisms of nicotine‐induced liver injury, the caspase cascade, and the Akt/NF‐κB signaling pathway, as well as the protective effects of dexpanthenol (DEX). Male rats were subjected to intraperitoneal injections of nicotine at a concentration of 0.5 mg/kg/day and/or DEX at a concentration of 500 mg/kg/day for 8 weeks. After the treatment period, liver function tests were conducted on serum samples, and tissue samples were analyzed for protein levels of Akt, NF‐κB, Bax, Bcl‐xL, Caspase‐3, and Caspase‐9, along with histopathological changes. Additionally, assessments of oxidative stress markers and proinflammatory cytokines were carried out. Nicotine administration led to elevated levels of IL‐6, IL‐1β, MDA, TOS, and oxidative stress index, accompanied by decreased TAS levels. Moreover, nicotine exposure reduced the p‐Akt/Akt ratio, increased NF‐κB, Bax, Caspase‐3, and Caspase‐9 protein levels, and decreased the antiapoptotic protein Bcl‐xL levels. DEX treatment significantly mitigated these effects, restoring the parameters to levels comparable to those of the control group. Nicotine‐induced liver injury resulted in oxidative stress, inflammation, and apoptosis, mediated by Bax/Bcl‐xL, Caspase‐3, Caspase‐9, and Akt/NF‐κB pathways. Conversely, DEX effectively attenuated nicotine‐induced liver injury by modulating apoptosis through NF‐κB, Caspase‐3, Caspase‐9, Bax inhibition, and Bcl‐xL activation.

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Lercanidipine alleviates doxorubicin-induced lung injury by regulating PERK/CHOP and Bax/Bcl 2/Cyt c pathways

Tepebaşı,

Selli,

Gül

et al. 2023

Histochem Cell Biol

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Dexpanthenol ameliorates doxorubicin-induced lung injury by regulating endoplasmic reticulum stress and apoptosis

Cited by 4 publications

References 41 publications

Amino-Functionalized Zirconium-Based Metal–Organic Frameworks as Bifunctional Nanomaterials to Treat Bone Tumors and Promote Osteogenesis

Amino-Functionalized Zirconium-Based Metal–Organic Frameworks as Bifunctional Nanomaterials to Treat Bone Tumors and Promote Osteogenesis

Dexpanthenol exhibits antiapoptotic and anti‐inflammatory effects against nicotine‐induced liver damage by modulating Bax/Bcl‐xL, Caspase‐3/9, and Akt/NF‐κB pathways

Lercanidipine alleviates doxorubicin-induced lung injury by regulating PERK/CHOP and Bax/Bcl 2/Cyt c pathways

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