Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats

Aras, Adem Bozkurt; Guven, Mustafa; Akman, Tolga; Özkan, Adile; Şen, Hacer; Duz, Ugur; Kalkan, Yıldıray; Silan, Coşkun; Çoşar, Murat

doi:10.4103/1673-5374.150724

Cited by 57 publications

(50 citation statements)

References 27 publications

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“…Similar to previous reports, the H 2 O 2 ‐treated cells showed a 40% decrease in cell proliferation compared to control cells, presumably due to an increase in ROS (Sattayasai et al, ). Natural compounds such as curcumin (Doggui, Sahni, Arseneault, Dao, & Ramassamy, ), geinstein (Baluchnejadmojarad, Roghani, Nadoushan, & Bagheri, ), and daidezin have all been found to inhibit ROS, thereby increasing the cell proliferation rate (Aras et al, ). Preincubation with SS effectively suppressed the decrease in cell proliferation by inhibiting the ROS increase.…”

Section: Discussionmentioning

confidence: 99%

Protective effects ofStachys sieboldiiMIQ extract in SK-N-SH cells and its memory ameliorative effect in mice

et al. 2017

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This work aims to evaluate the potential effect of Stachys sieboldii MIQ (SS) against oxidative stress induced by hydrogen peroxide (H2O2) in SK‐N‐SH cells and memory enhancement in ICR mice using the passive avoidance test. The effect of SS in cell proliferation was measured by BrdU incorporation assay with dosages of SS from 0 to 2 mg/mL. SS partially antagonized the effect of 150 μM H2O2 on cell proliferation. In vivo study, SS (100, 250, and 500 mg/kg) was administered orally to mice for 4 weeks. SS led to a significantly longer step‐through latency time compared to control mice. Memory enhancing effect of SS (500 mg/kg) was also observed in amnesia model, SS escalate the fear memory (p < .05), increase acetylcholine and choline acetyl transferase level in hippocampus and cortex than nontreated group. These results suggest that SS can be used to manage memory related disorders in animals. Practical applications Acetylcholine is a cholinergic neurotransmitter known for its various medicinal properties, reducing dementia, depression, cancer, inflammation, and is also required to build muscles in the human body. Hence, the development of a choline‐rich source is of great interest. SS is a good source for vitamins especially vitamin B complex, which is a major precursor for choline synthesis in human. Therefore, this study investigates the memory enhancement effects of Stachys sieboldii MIQ (SS), a choline‐rich plant, in SK‐N‐SH cells and an in vivo animal model. SK‐N‐SH cells and mice treated with SS exhibited memory ameliorative effects. This study sheds light on using plant‐based products as potential functional foods and nutraceuticals for cognition improvement. The results of this study could serve as a foundation for further research on SS extract as a source of choline and promotes the consumption of Stachys sieboldii on a large scale.

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Section: Discussionmentioning

confidence: 99%

Protective effects ofStachys sieboldiiMIQ extract in SK-N-SH cells and its memory ameliorative effect in mice

et al. 2017

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“…This discrepancy reflects imperfections of ARE-luc screen, with prolonged incubation times being the major disadvantage, which in the case of flavonoids results in monitoring the effect of their oxidative products as well. A good illustration to the above statement is soy isoflavone daidzein, which is supposed to be beneficial for survival under various stress conditions [48, 49]. However, based on our results, large portion of daidzein benefits one must ascribe to its major metabolite, 3’-hydroxydaidzein, the direct activator of both survival programs.…”

Section: Discussionmentioning

confidence: 69%

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease

Smirnova¹,

Kaidery²,

Hushpulian³

et al. 2016

Aging and disease

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Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase activation. To reveal specific structural requirements for direct stabilization of the transcription factors responsible for triggering the antihypoxic and antioxidant programs, we studied flavones, isoflavones and catechols including dihydroxybenzoate, didox, levodopa, and nordihydroguaiaretic acid (NDGA), using novel luciferase-based reporters specific for the first step in HIF1 or Nrf2 protein stabilization. Distinct structural requirements for either transcription factor stabilization have been found: as expected, these requirements for activation of HIF ODD-luc reporter correlate with in silico binding to HIF prolyl hydroxylase. By contrast, stabilization of Nrf2 requires the presence of 3,4-dihydroxy- (catechol) groups. Thus, only some but not all flavonoids are direct activators of the hypoxic and antioxidant genetic programs. NDGA from the Creosote bush resembles the best flavonoids in their ability to directly stabilize HIF1 and Nrf2 and is superior with respect to LOX inhibition thus favoring this compound over others. Given much higher bioavailability and stability of NDGA than any flavonoid, NDGA has been tested in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-animal model of Parkinson’s Disease and demonstrated neuroprotective effects.

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“…Accordingly, 3′‐methoxypuerarin and daidzein could protect rats against cerebral ischemia–reperfusion injury (Aras et al . , ; Liu et al . , ).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, ginsenosides, such as Rg1, Re, Rd, and Rb1, can reportedly act as neuroprotectants through various mechanisms, including inducing the expression of TIPE-2 , ameliorating lipid peroxidation (Zhou, Cao, & Dou, 2006), activating the PI3K/ Akt pathway and protecting the integrity of the blood-brain barrier (Chen et al, 2015). Accordingly, 3′methoxypuerarin and daidzein could protect rats against cerebral ischemia-reperfusion injury (Aras et al, 2015;Liu et al, 2010). Moreover, ferulic acid (Cheng et al, 2010), ligustilide (Peng et al, 2013) and senkyunolide I (Hu, Duan, Liang, & Wang, 2015) from L. wallichiii are active anti-cerebral ischemia substances.…”

Section: Analysis Of Constituents Of L Wallichiiimentioning

confidence: 99%

LC–high‐resolution–MS/MS analysis of chemical compounds in rat plasma after oral administration of Nao‐Mai‐Tong and its individual herbs

Rong

Shao

et al. 2017

Biomedical Chromatography

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Nao-Mai-Tong (NMT), a Chinese herbal formula, is used for treating ischemia cerebral apoplexy. To discover the components of NMT with potential in vivo bioactivity and investigate the differences between NMT and its single herb components, this study rigorously compared plasma samples collected from rats dosed with NMT and single-herb extracts at different times through LC-high resolution-MS/MS and data processing (Metworks). The plasma of the NMT group contained a total of 66 identified compounds (25 prototypes and 41 metabolites), including anthraquinones, triterpenoid saponins, isoflavones and phthalides. Additionally, glucuronidation, sulfation and cysteine conjugation were the major reactions through which the compounds in NMT were metabolized. The comparison of the groups revealed two metabolites that were only detected in the plasma from the NMT-dosed group, whereas seven prototype ingredients (chrysophanol-8-O-glucoside, ginsenoside Rf, Rg2, Rh1, F1, F2 and chikusetsusaponin IVa) and 12 metabolites (two novel triterpenoid saponins) were only discovered in the plasma samples from the single-herb-dosed groups. Moreover, the trends in the chemical compounds detected presented marked differences between NMT-dosed rat plasma and plasma samples from the single-herb-dosed groups. The above data indicate that prescription compatibility affects the assimilation and elimination of ingredients and provides useful information for further pharmacokinetic studies.

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Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats

Cited by 57 publications

References 27 publications

Protective effects ofStachys sieboldiiMIQ extract in SK-N-SH cells and its memory ameliorative effect in mice

Protective effects ofStachys sieboldiiMIQ extract in SK-N-SH cells and its memory ameliorative effect in mice

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease

LC–high‐resolution–MS/MS analysis of chemical compounds in rat plasma after oral administration of Nao‐Mai‐Tong and its individual herbs

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