Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia

Takasaki, Kotaro; Uchida, Koki; Fujikawa, Risako; Nogami, Ai; Nakamura, Kazuya; Kawasaki, Chihiro; Yamaguchi, Kazuko; Murakami, Masahiko; Morishita, Koji; Kubota, Kaori; Katsurabayashi, Shutaro; Mishima, Kenichi; Fujiwara, Michihiro; Iwasaki, Katsunori

doi:10.1254/jphs.11013fp

Cited by 29 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Citicoline has been found to improve spatial memory after brain ischemia 48 and CCI 20 in rats, but the present one is, to our knowledge, the first report of citicoline benefits on ORM after an experimental model of TBI. In contrast, mixed results have been obtained in human TBI patients.…”

Section: Citicoline Improved Memory In Tbi Animals But the Mechanismmentioning

confidence: 50%

Effects of Voluntary Physical Exercise, Citicoline, and Combined Treatment on Object Recognition Memory, Neurogenesis, and Neuroprotection after Traumatic Brain Injury in Rats

Jacotte-Simancas

David

Coll-Andreu

et al. 2015

Journal of Neurotrauma

View full text Add to dashboard Cite

The biochemical and cellular events that lead to secondary neural damage after traumatic brain injury (TBI) contribute to long-term disabilities, including memory deficits. There is a need to search for single and/or combined treatments aimed at reducing these TBI-related dysfunctions. The effects of citicoline and of voluntary physical exercise in a running wheel (3 weeks), alone or in combination, on TBI-related short-term (3 h) and long-term (24 h) object recognition memory (ORM) deficits, and on neurogenesis and neuroprotection were examined using a rodent model of TBI (controlled cortical impact injury). Citicoline improved memory deficits at the two times tested, while physical exercise only in the long-term test. Physical exercise had a clear neuroprotective effect as indicated by reduced interhemispheric differences in hippocampal formation and lateral ventricle volumes and in density of mature neurons in the hilus of the dentate gyrus and the perirhinal cortex. Physical exercise also increased cell proliferation and neurogenesis in the granular cell layer of the dentate gyrus. Some degree of neuroprotection of citicoline was suggested by reduced interhemispheric differences in the volume of the hippocampal formation. Contrary to what was expected, the effects of citicoline and physical exercise did not sum up.Furthermore, a negative interference between both treatments was found in several behavioral and histological variables. The promising profiles of both treatments as therapeutic tools in TBI when applied singly, underscore the need to carry out further works looking for other combined treatment regimens that increase the benefit of each treatment alone.4

show abstract

Section: Citicoline Improved Memory In Tbi Animals But the Mechanismmentioning

confidence: 50%

Effects of Voluntary Physical Exercise, Citicoline, and Combined Treatment on Object Recognition Memory, Neurogenesis, and Neuroprotection after Traumatic Brain Injury in Rats

Jacotte-Simancas

David

Coll-Andreu

et al. 2015

Journal of Neurotrauma

View full text Add to dashboard Cite

show abstract

“…In a clinical study, donepezil shortened NREM sleep and increased the amount of REM sleep [22] Ishida and Kamei also reported that donepezil resulted in an increased wakefulness time and decreased NREM sleep time in naïve rats during 3 h after treatment at a dose of 3 mg/kg [23]. Because our previous studies demonstrated that donepezil treatment reduced cognitive dysfunction in cerebral ischemia-treated rats at doses of 3 and 10 mg/kg [24], we evaluated the sleep-wakefulness profile at the lower donepezil dose in the present study. Therefore, other different times and doses of donepezil treatment may affect the sleep-wakefulness profile in cerebral ischemiatreated rats.…”

Section: Yokukansan Reduces Sleep Disturbancementioning

confidence: 99%

Effect of Yokukansan on sleep disturbance in a rat model of cerebrovascular dementia

Nagao

Takasaki

Nogami

et al. 2014

Traditional & Kampo Medicine

Self Cite

View full text Add to dashboard Cite

Aim: Symptoms of dementia are classified into cognitive dysfunction and behavioral and psychological symptoms of dementia, including sleep disturbance. Yokukansan (YKS) is effective for sleep disturbance in patients with dementia, but the mechanisms are still unclear. In this study, we evaluated sleep disturbance in rats with cerebral ischemia. We investigated the effect of YKS on sleep disturbance in cerebral ischemia-treated rats. Methods: Cerebral ischemia was induced by twice occluding both of the common carotid arteries. Wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep were classified using electroencephalography and electromyography. mRNA expression of sleep-wakefulness signals were quantified using reverse transcription-polymerase chain reaction. Results: Rats with cerebral ischemia had a higher total wakefulness time and lower total NREM sleep time during the light phase. These changes were ameliorated with 1000 mg/kg YKS for 14 days, but not 3 mg/kg donepezil for 7 days. mRNA expression of the prefrontal cortical prostaglandin (PG) E 2 (EP4) receptor and of the PGD 2 (DP) receptor was increased by cerebral ischemia. Elevated prefrontal cortical EP4 and DP receptor mRNA expression was reduced by YKS treatment. Conclusion: Rats with cerebral ischemia had NREM sleep disturbance. YKS might reduce this sleep disturbance by preventing neuroinflammation, and this was mediated by the EP4 and DP receptors in the prefrontal cortex.

show abstract

“…Interestingly, in vitro , CDP-choline or citicoline, a precursor for phosphatidylcholine and subsequently, sphingomyelin biosynthesis from ceramide prevented ethanol-induced apoptosis in these cells. CDP-choline has also been shown to alleviate neurodegeneration and stroke damage in human trials [164, 251, 252]. Choline is a rich source for methyl groups required to synthesize phosphatidylcholine in the Kennedy pathway of glycerophospholipid biosynthesis (Fig.…”

Section: Conclusion and Hypothesis: Developmental Niches May Be Mmentioning

confidence: 99%

It’s a Lipid’s World: Bioactive Lipid Metabolism and Signaling in Neural Stem Cell Differentiation

Bieberich

2012

Neurochem Res

View full text Add to dashboard Cite

Lipids are often considered membrane components whose function is to embed proteins into cell membranes. In the last two decades, studies on brain lipids have unequivocally demonstrated that many lipids have critical cell signaling functions; they are called “bioactive lipids”. Pioneering work in Dr. Robert Ledeen’s laboratory has shown that two bioactive brain sphingolipids, sphingomyelin and the ganglioside GM1 are major signaling lipids in the nuclear envelope. In addition to derivatives of the sphingolipid ceramide, the bioactive lipids discussed here belong to the classes of terpenoids and steroids, eicosanoids, and lysophospholipids. These lipids act mainly through two mechanisms: 1) direct interaction between the bioactive lipid and a specific protein binding partner such as a lipid receptor, protein kinase or phosphatase, ion exchanger, or other cell signaling protein; and 2) formation of lipid microdomains or rafts that regulate the activity of a group of raft-associated cell signaling proteins. In recent years, a third mechanism has emerged, which invokes lipid second messengers as a regulator for the energy and redox balance of differentiating neural stem cells (NSCs). Interestingly, developmental niches such as the stem cell niche for adult NSC differentiation may also be metabolic compartments that respond to a distinct combination of bioactive lipids. The biological function of these lipids as regulators of NSC differentiation will be reviewed and their application in stem cell therapy discussed.

show abstract

Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia

Cited by 29 publications

References 28 publications

Effects of Voluntary Physical Exercise, Citicoline, and Combined Treatment on Object Recognition Memory, Neurogenesis, and Neuroprotection after Traumatic Brain Injury in Rats

Effects of Voluntary Physical Exercise, Citicoline, and Combined Treatment on Object Recognition Memory, Neurogenesis, and Neuroprotection after Traumatic Brain Injury in Rats

Effect of Yokukansan on sleep disturbance in a rat model of cerebrovascular dementia

It’s a Lipid’s World: Bioactive Lipid Metabolism and Signaling in Neural Stem Cell Differentiation

Contact Info

Product

Resources

About