Neuroprotective Effects of Aframomum melegueta Extract after Experimental Traumatic Brain Injury

Kumar, Aswathi; Kennedy-Boone, Deborah; Weisz, Harris A.; Capra, Bridget A.; Uchida, Tatsuo; Jennings, Kristofer; Micci, Maria‐Adelaide; Parsley, Margaret A.; DeWitt, Douglas S.; Prough, Donald S.; Hellmich, Helen L.

doi:10.4172/2329-6836.1000167

Cited by 8 publications

(8 citation statements)

References 43 publications

(45 reference statements)

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“…Immunohistochemical analysis of injured rat brain sections using an antibody to CD11b (a marker of activated microglia) showed that this extract reduced microglial activation in the rat cortex and hippocampus. It also showed that the administration of A. melegueta extract after injury reduced the number of Fluoro‐Jade (a marker for neuronal injury) positive neurons in the CA1/2 and CA3 regions on the hippocampus of ipsilateral side …”

Section: Resultsmentioning

confidence: 95%

“…The protective effect of formononetin on neurobehavioral disorders after or before TBI may be associated with its inhibition of pro‐inflammatory cytokines and oxidative stress as well as activation of Nrf2‐dependent antioxidant pathways . It has been shown hydroethanolic extract of A. melegueta on TBI normalized the genes that are implicated in the chemokine, cytokine, oxidative stress, and NF‐κB signaling pathways induced by TBI . Protective effect of allicin on TBI is potentially associated with its antioxidative and anti‐inflammatory properties through the Akt/eNOS pathway .…”

Section: Molecular Mechanisms Underlying the Neuroprotective Effects mentioning

confidence: 99%

“…It also showed that the administration of A. melegueta extract after injury reduced the number of Fluoro-Jade (a marker for neuronal injury) positive neurons in the CA1/2 and CA3 regions on the hippocampus of ipsilateral side. 10…”

Section: Aframomum Meleguetamentioning

confidence: 99%

“…8,9 It has been shown hydroethanolic extract of A. melegueta on TBI normalized the genes that are implicated in the chemokine, cytokine, oxidative stress, and NF-κB signaling pathways induced by TBI. 10 Protective effect of allicin on TBI is potentially associated with its antioxidative and anti-inflammatory properties through the Akt/eNOS pathway. 69 The protective effects of artesunate in TBI also occur through inhibition of pro-inflammatory cytokines and apoptosis process by reducing the Bax expression and increasing Bcl2 expression, as well as modulation of various neurotrophic factors.…”

Section: Molecular Mechanisms Underlying the Neuroprotective Effectmentioning

confidence: 99%

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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

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Section: Resultsmentioning

confidence: 95%

Section: Molecular Mechanisms Underlying the Neuroprotective Effects mentioning

confidence: 99%

Section: Aframomum Meleguetamentioning

confidence: 99%

Section: Molecular Mechanisms Underlying the Neuroprotective Effectmentioning

confidence: 99%

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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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“…Moreover, the seed extract of AM is used as tonic in conditions associated with nervous weakness such as impotence and fatigue, which also represent prominent symptoms of major depression (Gautam et al, ). It has also been suggested that the seeds of AM might be useful for diseases, with inflammation as their hallmarks, such as cardiovascular conditions, arthritis, osteoporosis, and Alzhiemer's disease (Kumar et al, ).…”

Section: Introductionmentioning

confidence: 99%

Psychopharmacological evaluation of antidepressant-like activity of ethanol seed extract of grains of paradise (Aframomum meleguetaK. Schum.)in mice

2018

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The antidepressant-like activity of ethanol seed extract of Aframomum melegueta (AM) in mice was evaluated in this study. The duration of immobility was measured 30 min after oral administration of AM (25-400 mg/kg) in forced swim test. In the unpredictable chronic mild stress (UCMS) paradigm, mice were treated with AM (25-100 mg/kg) 30 min before exposure to different stressors for 14 days. Thereafter, sucrose preference test, tail suspension test, and test for anxiety were done. The brain concentrations of malondialdehyde and glutathione were estimated spectrophotometrically. Brain histology and population of healthy neurons in cornu ammonis 3 of the hippocampus were also assessed. AM (25 and 50 mg/kg) significantly decreased the duration of immobility in forced swim test and prevented UCMS-induced anhedonia and anxiety-like behaviors, suggesting antidepressant potentials. The extract decreased malondialdehyde and increased glutathione concentrations in UCMS-induced mice. Therefore, AM extract offers protection against UCMS-induced damage to cornu ammonis 3 hippocampal neuronal cells indicating neuroprotection. Practical applicationsThe seed of Grains of Paradise (Aframomum melegueta) is used in traditional medicine for fatigue and impotence, which are prominent symptoms of major depression. It is also widely chewed for its presumed central nervous system stimulant and endurance promoting effects. The results of this study revealed valuable evidence concerning the possible use of Grains of Paradise as an affordable natural, alternative, and/or complementary therapy with antioxidative and neuroprotective potentials. Consumption of these seeds in the right quantity might provide health benefits as Grains of Paradise exhibited antidepressant-like effect via inhibition of oxidative stress and neuroprotection.

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An update on pathophysiology and treatment of sports-mediated brain injury

Kalra

Banderwal

Arora

et al. 2022

Environ Sci Pollut Res

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Neuroprotective Effects of Aframomum melegueta Extract after Experimental Traumatic Brain Injury

Cited by 8 publications

References 43 publications

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Psychopharmacological evaluation of antidepressant-like activity of ethanol seed extract of grains of paradise (Aframomum meleguetaK. Schum.)in mice

An update on pathophysiology and treatment of sports-mediated brain injury

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