Neuroprotective effect of  -theanine in a rat model of chronic constriction injury of sciatic nerve-induced neuropathic pain

Chen, Shumei; Wang, Mao‐Hsien; Soung, Hung-Sheng; Tseng, Hsiang-Chien; Fang, Chia Lang; Lin, Yi‐Wen; Yang, Chao‐Hsun; Tsai, Cheng-Chia

doi:10.1016/j.jfma.2021.08.023

Cited by 17 publications

(16 citation statements)

References 43 publications

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“…Similarly, many research studies have reported that L-theanine administration also notably prevented the increase of serum TNF-α, IL-1β, and IL-6 levels in serum. 36,37 Additionally, in the KEGG pathway results of the transcriptomic analysis, it was also observed that DSS treatment significantly affected the "cytokine−cytokine receptor interaction" pathway, which was regarded as crucial effects on inflammation. Interestingly, L-theanine administration also significantly influenced this pathway.…”

Section: ■ Discussionmentioning

confidence: 99%

Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway

Zhang

Yao

et al. 2021

J. Agric. Food Chem.

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The present study revealed the phylactic effects of l-theanine on a DSS-induced colitis mice model. The results showed that 3% DSS treatment significantly induced intestinal damage as reflected by DAI, histopathological feature, and colon length, while l-theanine pretreatment markedly prevented these trends to exert protective effects. Meanwhile, l-theanine pretreatment decreased the levels of TNF-α, IL-1β, IL-6, iNOS, and COX2 on DSS-induced colitis. Notably, DSS inhibited the proliferation and promoted the apoptosis of intestinal epithelial cells, thereby damaging the integrity of the intestinal epithelial barrier, whereas l-theanine also played a protective role by attenuating these deteriorated effects. It was also observed that l-theanine treatment downregulated the levels of p-p65, p65, p-p53, p53, and p-AKT protein expression in acute DSS-induced colitis, which showed the protective function of l-theanine, mainly via the NF-κB signaling pathway. Furthermore, the results of lipid analysis and transcriptome analysis show that l-theanine reversed transcriptional profiles and lipid profiles of colitis models, mainly via the inflammatory reactivity-related pathway. Interestingly, the correlation analysis between transcriptional profiles and lipid profiles showed that inflammatory response-related genes were almost significantly correlated with differential lipid metabolites. In summary, l-theanine plays a protective role in DSS-induced colitis via downregulating the NF-κB signaling pathway and regulating lipid metabolism disorders.

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Section: ■ Discussionmentioning

confidence: 99%

Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway

Zhang

Yao

et al. 2021

J. Agric. Food Chem.

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“…The herb cha is a daily beverage as well as a medicinal herb with anti-inflammatory activity ( Yang et al, 2014 ). Its major amino acid components, L-theanine, exhibited neuroprotective properties in rodent animals against injury from constriction, stress and toxicity ( Jamwal et al, 2017 ; Jamwal and Kumar, 2017 ; Unno et al, 2020 ; Chen et al, 2022b ). Additionally, its major polyphenol, epigallocatechin-3-gallate was proved to be beneficial for neuropathic pain alleviation in chronic constriction injured mice models ( Bosch-Mola et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

et al. 2022

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Background: Treatment effect of current pharmacotherapies for migraine is unsatisfying. Discovering new anti-migraine natural products and nutraceuticals from large collections of Chinese medicine classical literature may assist to address this gap.Methods: We conducted a comprehensive search in the Encyclopedia of Traditional Chinese Medicine (version 5.0) to obtain migraine-related citations, then screened and scored these citations to identify clinical management of migraine using oral herbal medicine in history. Information of formulae, herbs and symptoms were further extracted. After standardisation, these data were analysed using frequency analysis and the Apriori algorithm. Anti-migraine effects and mechanisms of actions of the main herbs and formula were summarised.Results: Among 614 eligible citations, the most frequently used formula was chuan xiong cha tiao san (CXCTS), and the most frequently used herb was chuan xiong. Dietary medicinal herbs including gan cao, bai zhi, bo he, tian ma and sheng jiang were identified. Strong associations were constructed among the herb ingredients of CXCTS formula. Symptoms of chronic duration and unilateral headache were closely related with herbs of chuan xiong, gan cao, fang feng, qiang huo and cha. Symptoms of vomiting and nausea were specifically related to herbs of sheng jiang and ban xia.Conclusion: The herb ingredients of CXCTS which presented anti-migraine effects with reliable evidence of anti-migraine actions can be selected as potential drug discovery candidates, while dietary medicinal herbs including sheng jiang, bo he, cha, bai zhi, tian ma, and gan cao can be further explored as nutraceuticals for migraine.

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“…For the EORTC QLQ-OES18 scale, the analysis found that postoperative tea consumption improved significantly on eating problems, odynophagia, trouble swallowing saliva, coughing and speech problems. The main mechanism may be through the antioxidant and antiinflammatory effects of L-theanine [24] and epigallocatechin [25] components in tea to achieve improve pain and maintain a stable oral environment. This suggests that cancer patients may improve their oral environment and thus symptoms such as difficulty eating, dry mouth, cough and swallowing by drinking tea.…”

Section: Discussionmentioning

confidence: 99%

Improvement of postoperative quality of life in patients with esophageal squamous cell carcinoma: does tea consumption have a role?

et al. 2022

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Background To investigate the effect of tea consumption on the improvement of postoperative quality of life in male patients with esophageal squamous cell carcinoma (ESCC). Methods The quality of life information of 290 male patients with ESCC was collected. The time to deterioration and the number of events in each area of quality of life was calculated by time-to-deterioration (TTD) model. The association between postoperative tea drinking and postoperative quality of life in male ESCC patients was investigated using the Cox proportional risk model. Results Postoperative tea-drinking patients experienced delayed TTD in multiple domains, including general health, physical, role, emotional, and cognitive function, fatigue, nausea and vomiting, dyspnea, loss of appetite, constipation, diarrhea, eating problems, difficulty swallowing, choking while swallowing saliva, dry mouth, taste difficulties, coughing, and speech problems. The multivariate Cox regression analysis showed that drinking tea after surgery improved quality of life, including physical function (HR = 0.722, 95% CI: 0.559-0.933), role function (HR = 0.740, 95% CI: 0.557-0.983), eating problems (HR = 0.718, 95% CI: 0.537-0.960), odynophagia (HR = 0.682, 95% CI: 0.492-0.945), trouble swallowing saliva (HR = 0.624, 95% CI: 0.444-0.877), coughing (HR = 0.627, 95% CI: 0.442-0.889) and speech problems (HR = 0.631, 95% CI: 0.441-0.903). Furthermore, the improvement was more significant in patients who drank tea before surgery and continued to drink tea after surgery. Conclusions Postoperative tea drinking had a positive effect on delay in clinical deterioration and improvements in multiple functions and symptoms associated with ESCC in men.

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Neuroprotective effect of -theanine in a rat model of chronic constriction injury of sciatic nerve-induced neuropathic pain

Cited by 17 publications

References 43 publications

Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway

Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

Improvement of postoperative quality of life in patients with esophageal squamous cell carcinoma: does tea consumption have a role?

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