Neuroprotective effect of tadalafil, a PDE-5 inhibitor, and its modulation by L-NAME in mouse model of ischemia-reperfusion injury

Gulati, Puja; Singh, Nirmal

doi:10.1016/j.jss.2013.08.005

Cited by 26 publications

(29 citation statements)

References 54 publications

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“…[25,26] Similar efficiency has been reported in decreasing oxidative stress related to SCI. [27] Neuroprotection mechanism of tadalafil is not yet known; neurogenesis, synaptic plasticity, and physiological modulation of neurotransmitters caused by cGMP have all been proposed.…”

Section: Discussionsupporting

confidence: 59%

Therapeutic Efficacy of Tadalafil and Eriythropoietin in Experimental Spina Cord Injury

Kökoğlu

Delen²,

Arslantaş³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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Section: Discussionsupporting

confidence: 59%

Therapeutic Efficacy of Tadalafil and Eriythropoietin in Experimental Spina Cord Injury

Kökoğlu

Delen²,

Arslantaş³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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“…Previous study also observed the antioxidative property of tadalafil in animal model (Gulati and Singh, 2014;Rashid et al, 2012). Brain TBARS activity and nitrite levels were also measured by Gulati and Singh (2014).…”

Section: Discussionmentioning

confidence: 77%

Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice

Al-Amin

Hasan

Alam

et al. 2014

European Journal of Pharmacology

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“…Tadalafil (TAD, generously gifted by Panacea Biotech Ltd., India), freshly dissolved in NS (Demchenko et al 2009), was administered as 5, 10, or 20 mg/kg per os (p.o.) (Bishara et al 2012;Gulati and Singh 2014;Kutuk et al 2012;Liebenberg et al 2010). Indomethacin (INDO, Indocap Ò capsule, Jagsonpal Pharmaceuticals Ltd., India), first dissolved in 0.2 N NaOH followed by pH adjustment to 7.3 with TrisHCl (0.05 %) and volume adjustment with NS, was administered as 4 mg/kg, i.p.…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

Involvement of NO–cGMP pathway in anti-hyperalgesic effect of PDE5 inhibitor tadalafil in experimental hyperalgesia

Otari¹,

Upasani²

2015

Inflammopharmacol

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The association of elevated level of cyclic guanosine monophosphate (cGMP) with inhibition of hyperalgesia and involvement of nitric oxide (NO)-cGMP pathway in the modulation of pain perception was previously reported. Phosphodiesterases 5 (PDE5) inhibitors, sildenafil and tadalafil (TAD) used in erectile dysfunction, are known to act via the NO-cGMP pathway. TAD exerts its action by increasing the levels of intracellular cGMP. Hence, the present study investigated the effect of TAD 5, 10, or 20 mg/kg, per os (p.o.) or L-NAME 20 mg/kg, intraperitoneally (i.p.) and TAD (20 mg/kg, p.o.) in carrageenan- and diabetes-induced hyperalgesia in rats using hot plate test at 55 ± 2 °C. In carrageenan- and diabetes-induced hyperalgesia, TAD (10 and 20 mg/kg, p.o.) significantly increased paw withdrawal latencies (PWLs) as compared to the control group. L-NAME significantly decreased PWLs as compared to the normal group and aggravated the hyperalgesia. Moreover, significant difference in PWLs of L-NAME and TAD 20 was evident. Co-administration of L-NAME (20 mg/kg) with TAD (20 mg/kg) showed significant difference in PWLs as compared to the TAD (20 mg/kg), indicating L-NAME reversed and antagonized TAD-induced anti-hyperalgesia. This suggested an important role of NO-cGMP pathway in TAD-induced anti-hyperalgesic effect.

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Neuroprotective effect of tadalafil, a PDE-5 inhibitor, and its modulation by L-NAME in mouse model of ischemia-reperfusion injury

Cited by 26 publications

References 54 publications

Therapeutic Efficacy of Tadalafil and Eriythropoietin in Experimental Spina Cord Injury

Therapeutic Efficacy of Tadalafil and Eriythropoietin in Experimental Spina Cord Injury

Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice

Involvement of NO–cGMP pathway in anti-hyperalgesic effect of PDE5 inhibitor tadalafil in experimental hyperalgesia

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