Therapeutic Efficacy of Tadalafil and Eriythropoietin in Experimental Spina Cord Injury

Abstract

BACKGROUND: This experimental study was an investigation of the efficacy of erythropoietin and tadalafil in rats with induced spinal cord injury (SCI).

Neurological recovery and antioxidant effect of erythropoietin for spinal cord injury: A systematic review and meta-analysis

“…The meta-analysis indicated that SCI rats receiving EPO therapy showed a significant locomotor function recovery in all studies (1 d to 28 d, P < 0.01; Figure 2 ). After the intervention of EPO, the BBBs score increased [1 d, 21 studies ( 18 , 25 , 35 – 37 , 41 , 43 – 46 , 48 , 49 , 51 , 54 , 59 , 61 , 63 – 65 ), WMD = 0.69, 95% CI [0.22, 1.15], P = 0.004; 3 d, 17 studies ( 18 , 25 , 35 , 42 , 43 , 46 , 48 , 49 , 58 , 63 , 66 – 70 ), WMD = 2.50, 95% CI [1.69, 3.31], P < 0.00001; 7 d, 24 studies ( 18 , 25 , 35 , 36 , 42 , 43 , 45 , 46 , 48 , 49 , 54 , 58 , 59 , 63 , 65 , 67 – 69 , 71 – 74 ), WMD = 3.31, 95% CI [2.21, 4.41], P < 0.00001; 14 d, 20 studies ( 18 , 25 , 35 , 42 , 43 , 45 , 46 , 48 , 49 , 58 , 59 , 63 , 65 , 67 – 69 , 73 , 74 ), WMD = 3.80, ...…”

“…MDA has been widely used as a convenient biomarker for lipid peroxidation of omega-3 and omega-6 fatty acids due to its easy reaction with thiobarbituric acid ( 66 , 67 ). Three studies measured MDA levels after SCI and found that MDA levels were significantly lower in the EPO group than the matched group of controls [2 studies ( 42 , 58 ), WMD = −0.63, 95% CI (−1.09 to −0.18), P = 0.007; Figure 5 ] to detect its antioxidative effect.…”