Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow

Yu, Di; Fan, Changfeng; Zhang, Weiyan; Wen, Zhongyuan; Hu, Liang; Yang, Lei; Feng, Yuping; Yin, Ke‐Jie; Mo, Xuming

doi:10.1016/j.jns.2015.07.010

Cited by 20 publications

(6 citation statements)

References 38 publications

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“…Conversely, NR treatment significantly reduced Bax and Caspase-3 and significantly increased the level of Bcl-2 hence renovating the Bax/Bcl-2 ratio in the NR treated animals as compared to the GM treated ones. These results are in line with earlier studies of He et al and Yu et al 42,56 . Altogether, the antiapoptotic effects of NR might be related to its antioxidative properties as well as suppression of the p38MAPK-mediated activation of NF-κB 42 .…”

Section: Discussionsupporting

confidence: 94%

Nicorandil ameliorates gentamicin-induced nephrotoxicity through Nrf2/HO-1, p38 MAPK/NF-κB p65/NO and miR-7/CHOP pathways

El-Azeem

Abdel-Sattar²,

Ahmed³

2022

Azhar International Journal of Pharmaceutical and Medical Scien

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Section: Discussionsupporting

confidence: 94%

Nicorandil ameliorates gentamicin-induced nephrotoxicity through Nrf2/HO-1, p38 MAPK/NF-κB p65/NO and miR-7/CHOP pathways

El-Azeem

Abdel-Sattar²,

Ahmed³

2022

Azhar International Journal of Pharmaceutical and Medical Scien

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“…The brains were removed and stored in the 4% paraformaldehyde solution overnight at 4 °C. The samples were dehydrated in a graded ethanol series, and then embedded in paraffin 34 . Coronal sections were cut at 5μm in thickness using rotary microtome (RM2235, Leica Biosystems Nussloch GmbH, Heidelberger, Germany) and standard HE stain was performed 35 .…”

Section: Methodsmentioning

confidence: 99%

Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound

Zhao

Zhou

et al. 2016

Sci Rep

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Low frequency ultrasound (<1 MHz) has been demonstrated to be a promising approach for non-invasive neuro-stimulation. However, the focal width is limited to be half centimeter scale. Minimizing the stimulation region with higher frequency ultrasound will provide a great opportunity to expand its application. This study first time examines the feasibility of using high frequency (5 MHz) ultrasound to achieve neuro-stimulation in brain, and verifies the anatomical specificity of neuro-stimulation in vivo. 1 MHz and 5 MHz ultrasound stimulation were evaluated in the same group of mice. Electromyography (EMG) collected from tail muscles together with the motion response videos were analyzed for evaluating the stimulation effects. Our results indicate that 5 MHz ultrasound can successfully achieve neuro-stimulation. The equivalent diameter (ED) of the stimulation region with 5 MHz ultrasound (0.29 ± 0.08 mm) is significantly smaller than that with 1 MHz (0.83 ± 0.11 mm). The response latency of 5 MHz ultrasound (45 ± 31 ms) is also shorter than that of 1 MHz ultrasound (208 ± 111 ms). Consequently, high frequency (5 MHz) ultrasound can successfully activate the brain circuits in mice. It provides a smaller stimulation region, which offers improved anatomical specificity for neuro-stimulation in a non-invasive manner.

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“…Dysfunction of PI3K-Akt-mTOR cascade has been recognized as the root cause of both neurodevelopmental and neuropsychiatric diseases with distinct clinical phenotypes, such as autism spectrum disorder, epilepsy, brain injury, and a spectrum of developing brain malformations (Crino 2016; Wang et al 2015; Yang & Mo 2016; Yu et al 2015). In this review, we discuss the functions of this pathway during embryonic forebrain development, with a particular focus on the putative molecular mechanisms underlying these functions (Fig.…”

Section: Introductionmentioning

confidence: 99%

Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases

et al. 2016

Self Cite

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Neurodevelopmental biology, coupled with the application of advanced histological, imaging, molecular, cellular, biochemical, and genetic approaches, has provided new insights into these intricate genetic, cellular, and molecular events. During telencephalic development, specific neural progenitor cells (NPCs) proliferate, differentiate into numerous cell types, migrate to their apposite positions, and form an integrated circuitry. Critical disturbance to this dynamic process via genetic and environmental risk can cause neurological disorders and disability. The phosphatidylinositol-3-OH kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling cascade contributes to mediate various cellular processes, including cell proliferation and growth, and nutrient uptake. In light of its critical function, dysregulation of this node has been regarded as a root cause of several neurodevelopmental diseases, such as megalencephaly (“big brain”), microcephaly (“small brain”), autism spectrum disorders, intellectual disability, schizophrenia, and epilepsy. In this review, particular emphasis will be given to the PI3K-Akt-mTOR signaling pathway and their paramount importance in neurodevelopment of the cerebral neocortex, because of its critical roles in complex cognition, emotional regulation, language, and behaviors.

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Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow

Cited by 20 publications

References 38 publications

Nicorandil ameliorates gentamicin-induced nephrotoxicity through Nrf2/HO-1, p38 MAPK/NF-κB p65/NO and miR-7/CHOP pathways

Nicorandil ameliorates gentamicin-induced nephrotoxicity through Nrf2/HO-1, p38 MAPK/NF-κB p65/NO and miR-7/CHOP pathways

Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound

Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases

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