RETRACTED ARTICLE: Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats

Abstract

The present study was aimed to evaluate the protective effect of hesperidin (Hes) on aluminium chloride (AlCl3) induced neurobehavioral and pathological changes in Alzheimeric rats. Intraperitonial injection of AlCl3 (100 mg/kg body weight) for 60 days significantly elevated the levels of aluminium (Al), activity of acetylcholinesterase (AChE) and protein expressions of amyloid precursor protein (APP), β amyloid (Aβ 1-42), β and γ secretases as compared to control group in hippocampus and cortex of rat brain. Hes administration orally along with AlCl3 injection for 60 days, significantly revert the Al concentration, AChE activity and Aβ synthesis-related molecules in the studied brain regions. Our results showed that aluminum exposure was significantly reduced the spontaneous locomotor and exploratory activities in open field test and enhanced the learning and memory impairments in morris water maze test. The behavioral impairments caused by aluminum were significantly attenuated by Hes. The histopathological studies in the hippocampus and cortex of rat brain also supported that Hes (100 mg/kg) markedly reduced the toxicity of AlCl3 and preserved the normal histoarchitecture pattern of the hippocampus and cortex. From these results, it is concluded that hesperidin can reverse memory loss caused by aluminum intoxication through attenuating AChE activity and amyloidogenic pathway.

Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

“…Hesperidin at the dose of 100 mg/kg and silibinin (100 and 200 mg/kg) significantly prevented the AChE elevation in the hippocampus. Our results are in accordance with the earlier studies with regards to the AChE inhibitor activity of hesperidin and silibinin [32,56,61,62]. Inhibition of AlCl 3 -evoked hippocampal AChE level by hesperidin and silibinin might be attributed to the improvement in the memory function.…”

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

“…Bioflavonoid like HSP may inhibit induction of antioxidant enzyme activities and may play a role in tissue protection. Neuroprotective effect of hesperidin on aluminum chloride induced Alzheimer's disease in Wistar rats has been shown earlier [53]. Protective activities of HSP against microbes and several toxicities induced by oxidants, chemicals, toxins, chemotherapy, and radiotherapy agents has been shown earlier in in vitro and in vivo studies [54].…”

Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway

“…People residing nearby areas of the cement factories are more prone to Al exposure as dispersed particulate matters contain high amount of aluminum [6]. Previous animal studies from our laboratory indicated that Al-induced neuropathological, neurochemical and neurobehavioral changes similar to AD [4,7,8]. Since Al is an environmental neurotoxin, whose exposure is get increased due to lifestyle changes and implicated in the pathogenesis of AD, the current experiment was designed.…”