Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice

Selvaraju, M.; Umayaparvathi, S.; Saravanan, R.; Manivasagam, Thamilarasan; Balasubramanian, T.

doi:10.1016/j.ijbiomac.2015.12.025

Cited by 49 publications

(16 citation statements)

References 47 publications

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“…In this study, we also observed a significant increase in the oxidative products such as MDA, 3-NT, and 8-OHdG in the ventral midbrain of rotenone-lesioned PD rats. Encouragingly, fucoidan remarkably inhibited the increase of these oxidative products in accordance with previous reports [ 32 ]. These results suggest that fucoidan can enhance the mitochondrial function and thereby alleviate the oxidative stress in the ventral midbrain of rotenone-treated rats.…”

Section: Discussionsupporting

confidence: 92%

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

et al. 2018

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The mitochondrion is susceptible to neurodegenerative disorders such as Parkinson’s disease (PD). Mitochondrial dysfunction has been considered to play an important role in the dopaminergic degeneration in PD. However, there are no effective drugs to protect mitochondria from dysfunction during the disease development. In the present study, fucoidan, a sulfated polysaccharide derived from Laminaria japonica, was investigated and characterized for its protective effect on the dopamine system and mitochondrial function of dopaminergic neurons in a rotenone-induced rat model of PD. We found that chronic treatment with fucoidan significantly reversed the loss of nigral dopaminergic neurons and striatal dopaminergic fibers and the reduction of striatal dopamine levels in PD rats. Fucoidan also alleviated rotenone-induced behavioral deficits. Moreover, the mitochondrial respiratory function as detected by the mitochondrial oxygen consumption and the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and nuclear transcription factor 2 (NRF2) were reduced in the substantia nigra of PD rats, which were markedly reversed by fucoidan. Oxidative products induced by rotenone were significantly reduced by fucoidan. Taken together, these results demonstrate that fucoidan possesses the ability to protect the dopamine system in PD rats. The neuroprotective effect of fucoidan may be mediated via reserving mitochondrial function involving the PGC-1α/NRF2 pathway. This study provides new evidence that fucoidan can be explored in PD therapy.

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Section: Discussionsupporting

confidence: 92%

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

et al. 2018

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“…The ability to balance and coordinate is widely used as a measure of motor skill. When administered in mice, MPTP decreases behavioral functions and striatal DA levels [ 32 , 33 ]. In the present study, mice treated with MPTP showed a reduction in spontaneous activities, balance vestibular integrity and muscular coordination compared to the control group, as evidenced by the open field test, pole test and traction test.…”

Section: Discussionmentioning

confidence: 99%

Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model

et al. 2020

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Parkinson’s disease (PD), characterized by dopaminergic neuron degeneration in the substantia nigra and dopamine depletion in the striatum, affects up to 1% of the global population over 50 years of age. Our previous study found that a heteropolysaccharide from Saccharina japonica exhibits neuroprotective effects through antioxidative stress. In view of its high molecular weight and complex structure, we degraded the polysaccharide and subsequently obtained four oligosaccharides. In this study, we aimed to further detect the neuroprotective mechanism of the oligosaccharides. We applied MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to induce PD, and glucuronomannan oligosaccharides (GMn) was subsequently administered. Results showed that GMn ameliorated behavioral deficits in Parkinsonism mice. Furthermore, we observed that glucuronomannan oligosaccharides contributed to down-regulating the apoptotic signaling pathway through enhancing the expression of tyrosine hydroxylase (TH) in dopaminergic neurons. These results suggest that glucuronomannan oligosaccharides protect dopaminergic neurons from apoptosis in PD mice.

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“…Fucoxanthin showed cytotoxic effects by inducing apoptosis of prostate cancer cell line PC-3 (Kotake-Nara et al, 2001), leukemia HL-6 (Nakazawa et al, 2009), and 6 colorectal cell lines, Caco-2, WiDr, HCT116, DLD-1, SW620, Colo205, Caco-2 cell lines (Takahashi et al, 2015). Turbinaria decurrens Bory also contain fucoidan that has been studied showing neuroprotective (Meenakshi et al, 2016) and hepatoprotective effects (Meenakshi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116

2018

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Turbinaria deccurrens Bory contains bioactive compound that is beneficial for health. Turbinaria deccurrens Bory is one of many species of brown seaweed that grows in Indonesian marine life and has been known to have cytotoxic activity. The aim of this study is to determine fucoxantin content and the cytotoxic activity of extract and fraction T. decurrens on colon cancer cell lines. Cytotoxic assay of ethanolic extract, n-hexane, ethyl acetate and ethanolic fractions against HCT-116 by MTS assay using Cell Counting Kit-8 (CCK-8). Fucoxantin content in extract and fraction were analyzed using Reversed-Phase High Performance Liquid Chromatography (RP-HPLC) analysis. Extract and fraction of T. decurrens contain fucoxanthin with the highest content of fucoxanthin was in ethyl acetate fraction. CCK-8 assay showed that extract, n-hexane and ethyl acetate fraction inhibited the growth of HCT-116. Brown seaweed Turbinaria decurrens was potential as an anticolon cancer agent.

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Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice

Cited by 49 publications

References 47 publications

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model

Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116

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