2016
DOI: 10.1016/j.ijbiomac.2015.12.025
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Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice

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Cited by 48 publications
(14 citation statements)
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“…In this study, we also observed a significant increase in the oxidative products such as MDA, 3-NT, and 8-OHdG in the ventral midbrain of rotenone-lesioned PD rats. Encouragingly, fucoidan remarkably inhibited the increase of these oxidative products in accordance with previous reports [ 32 ]. These results suggest that fucoidan can enhance the mitochondrial function and thereby alleviate the oxidative stress in the ventral midbrain of rotenone-treated rats.…”
Section: Discussionsupporting
confidence: 92%
“…In this study, we also observed a significant increase in the oxidative products such as MDA, 3-NT, and 8-OHdG in the ventral midbrain of rotenone-lesioned PD rats. Encouragingly, fucoidan remarkably inhibited the increase of these oxidative products in accordance with previous reports [ 32 ]. These results suggest that fucoidan can enhance the mitochondrial function and thereby alleviate the oxidative stress in the ventral midbrain of rotenone-treated rats.…”
Section: Discussionsupporting
confidence: 92%
“…The ability to balance and coordinate is widely used as a measure of motor skill. When administered in mice, MPTP decreases behavioral functions and striatal DA levels [ 32 , 33 ]. In the present study, mice treated with MPTP showed a reduction in spontaneous activities, balance vestibular integrity and muscular coordination compared to the control group, as evidenced by the open field test, pole test and traction test.…”
Section: Discussionmentioning
confidence: 99%
“…Fucoxanthin showed cytotoxic effects by inducing apoptosis of prostate cancer cell line PC-3 (Kotake-Nara et al, 2001), leukemia HL-6 (Nakazawa et al, 2009), and 6 colorectal cell lines, Caco-2, WiDr, HCT116, DLD-1, SW620, Colo205, Caco-2 cell lines (Takahashi et al, 2015). Turbinaria decurrens Bory also contain fucoidan that has been studied showing neuroprotective (Meenakshi et al, 2016) and hepatoprotective effects (Meenakshi et al, 2014).…”
Section: Introductionmentioning
confidence: 99%