Neuroprotective Effect of Cinnamaldehyde on Secondary Brain Injury After Traumatic Brain Injury in a Rat Model

Bektaşoğlu, Pınar Kuru; Koyuncuoğlu, Türkan; Demir, Dilan; Sucu, G.; Akakın, Dilek; Eyüboğlu, İrem Peker; Yüksel, Meral; Çelikoğlu, Erhan; Yeğen, Berrak Ç.; Gürer, Bora

doi:10.1016/j.wneu.2021.06.117

Cited by 12 publications

(10 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 5 , 8 , 25 , 27 , 48 CA has a potent antioxidant activity and its efficacy has been proven in a traumatic brain injury model. 23 In our investigation, serum and tissue CAT levels rose following CA and MP treatments while they dropped after SCIRI. The existence of elevated oxidative stress is indicated by the XO enzyme, which is a member of the ROS family.…”

Section: Discussionmentioning

confidence: 43%

“… 20 Also in another cerebral ischemia, traumatic brain injury and cerebral vasospasm models, CA exerted neuroprotective activity via anti-inflammatory properties. 21 , 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

“… 51 , 55 , 56 In numerous neuroinflammatory animal models, antiinflammatory, and neuroprotective activity of CA has been shown. 17 , 22 , 23 , 57 , 58 , 59 After spinal cord damage, MPO activity—a sign of neutrophil activation—increases. 60 In the current investigation, SCIRI enhanced the serum and tissue MPO activity, whereas CA and MP therapy lowered that elevated activity.…”

Section: Discussionmentioning

confidence: 99%

“… 22 In a recent study, we also showed that CA treatment has prevented cortical and hippocampal injury in a model for traumatic brain injury via its antioxidant properties. 23 The effectiveness of CA in SCIRI has not yet been proven.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cinnamaldehyde has ameliorative effects on rabbit spinal cord ischemia and reperfusion injury

Kuru Bektaşoğlu,

Arıkök,

Ergüder

et al. 2024

World Neurosurgery: X

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 43%

“… 20 Also in another cerebral ischemia, traumatic brain injury and cerebral vasospasm models, CA exerted neuroprotective activity via anti-inflammatory properties. 21 , 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cinnamaldehyde has ameliorative effects on rabbit spinal cord ischemia and reperfusion injury

Kuru Bektaşoğlu,

Arıkök,

Ergüder

et al. 2024

World Neurosurgery: X

Self Cite

View full text Add to dashboard Cite

“…Traumatic brain injury can seriously impair brain function and cause a number of ischemic pathologic changes in the brain's tissue. Cinnamaldehyde has demonstrated neuroprotective effects by limiting neutrophil recruitment, lowering reactive oxygen species, minimizing histologic damage, and alleviating acute hippocampal dysfunction (26) .…”

Section: • Neuro-inflammation Inhibitory Effectsmentioning

confidence: 99%

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

Kalaivani,

Murali,

Sathya

et al. 2023

IJST

View full text Add to dashboard Cite

Objective:The current review identifies the adverse and beneficial effects of cinnamon and its components. Method: Literature search using online databases including PubMed, Hindawi, ScienceDirect, ResearchGate, and Elsevier were explored. The keywords used for the literature search included cinnamon, cinnamaldehyde, trans-cinnamaldehyde, cinnamon and stroke, cinnamon and antioxidant, and cinnamon and toxic effects. The inclusion criteria for this review encompassed studies that focused on neuroinflammation and neuroprotection, as well as those that examined the effects of stroke. Additionally, the criteria included studies that investigated experiments on ischemic hemorrhage, encompassing both in vivo and in vitro settings. Findings: The comparative analysis of studies reveals that cinnamon demonstrates potent antioxidant, anticholinergic, and antidiabetic effects. Cinnamaldehyde exhibits inhibitory effects on collagen and thrombin-induced platelet aggregation, as well as collagen-epinephrine-induced acute pulmonary thromboembolism, suggesting its antithrombotic properties. Moreover, transcinnamaldehyde reduces the brain infarct area by downregulating the gene expression of iNOS, COX-2, and TNF-alpha, thus reducing inflammation associated with ischemic stroke. Additionally, the literature review highlights the neuroprotective properties of cinnamon in treating Alzheimer's disease and Parkinson's disease. Consequently, further research is required to elucidate the potential mechanisms through which cinnamon provides neuroprotection and its efficacy in stroke treatment. Novelty: The review reiterates for bioactive compounds present in cinnamon which show promising potential in the treatment of neurodegenerative disorders and stroke.

show abstract

Stereological and behavioural analysis reveals the better neuroprotective effect of cinnamaldehyde than berberine chloride in a rat model of global cerebral ischemia

Mehboodi,

Shahedi,

Namavar

et al. 2024

Traditional & Kampo Medicine

View full text Add to dashboard Cite

BackgroundGlobal cerebral ischemia (GCI) is characterized by the hindrance of blood flow to the brain due to obstruction in the carotid arteries. In this study, the neuroprotective effects of berberine chloride (BBR) and cinnamaldehyde (CA) against GCI in male Wistar rats were investigated, and their efficacy was compared.MethodsTwenty‐four rats were randomly assigned to four groups: Sham, GCI, GCI + BBR, and GCI + CA. 100 mg/kg of BBR and CA were administered five minutes and six hours after inducing GCI by occluding two common carotids for 20 minutes.ResultsThe findings showed that both compounds mitigated GCI‐induced damage to the hippocampus and its subfields, and CA demonstrated better neuroprotective efficacy than BBR. These results was also supported by behavioural tests, which revealed better memory function in GCI + CA compared to GCI + BBR.ConclusionThe study showed the neuroprotective impact of CA and BBR against GCI, and CA emerged as a more effective therapeutic agent against GCI‐induced damage. Further research is necessary to uncover the specific mechanisms behind these differences.

show abstract

Neuroprotective Effect of Cinnamaldehyde on Secondary Brain Injury After Traumatic Brain Injury in a Rat Model

Cited by 12 publications

References 66 publications

Cinnamaldehyde has ameliorative effects on rabbit spinal cord ischemia and reperfusion injury

Cinnamaldehyde has ameliorative effects on rabbit spinal cord ischemia and reperfusion injury

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

Stereological and behavioural analysis reveals the better neuroprotective effect of cinnamaldehyde than berberine chloride in a rat model of global cerebral ischemia

Contact Info

Product

Resources

About