Neuroprotective Compounds from Marine Microorganisms

Neurodegeneration include disease of the central nervous system (CNS) such as Parkinson’s disease (PD). The sign of this disease include destruction of dopaminergic neuronal cells. Main causes of this disease are unknown, but several studies reported polygenic causes. These include free radicals, malfunction of mitochondria, protein oxidation and DNA denaturation. Several reports implicated the involvement of oxygen species and stresses cause by over accumulation of reactive oxygen species in the contribution to the cascade that resulted in diminishing of dopamine cells destruction in this disease. Generally, natural defensive substances such as bio-cartelized (proteineous and non proteineous) from natural or synthetic sources played a unique role in protecting the susceptible neuronal cells from the adverse effects of the reactive oxygen species. In most cases antioxidant enzyme production by the body system diminished with advance age. Hence, treatment with antioxidant potential agent or administration of antioxidant substance with the common drugs used in the treatment of PD may yield positive result in protecting neurons from degenerative changes caused by reactive oxygen species. Recent studies on the therapeutic and prophylactic effect of some agents on experimental induced PD summarized in this review paper.

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“…NP7 was deleted. Result has shown that NP7 can be a potential oxidative stress defense agent for PD [71].…”

Section: Regulation Of Nof2/are Signaling By Deprenyl In Pc12 Cells Imentioning

confidence: 99%

Recent Studies on the Therapeutic and Prophylactic Effect of Some Agents on Experimental Induced Parkinson Disease Models Review

Hassan

Abdulkadir

2021

AJRB

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“…Result indicated that NP7 might be a promising neuroprotecting agent against oxidative stress in PD. [65] Bromocriptine, a DA agonist [Figure 7], has been widely used in PD clinics since 1974 to delay and minimize deleterious motor fluctuations after long-term l-dopa treatment. [66] Recent observations suggest that bromocriptine is a free-radical scavenger that scavenges hydroxyl and superoxide radicals in vitro and acts as an antioxidant that inhibits free-radical formation.…”

Section: Antioxidant Compounds In Experimental Models Of Pdmentioning

confidence: 99%

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Sarvananda¹

2021

IJPSCR

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Neurodegenerative movement disorder of the central nervous system (CNS) (Parkinson's disease [PD]) is characterized by necrosis of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. The etiology of PD is still unknown and is believed to be multifactorial, oxidative stress and mitochondrial dysfunction are widely considered major consequences, which provide important clues to the disease mechanisms. Studies have showed the role of free radicals and oxidative stress that contributes to the cascade of events leading to dopamine cell degeneration in PD. In general, in-built protective mechanisms consisting of enzymatic and non-enzymatic antioxidants in the CNS play decisive roles in preventing neuronal cell loss due to free radicals. However, the ability to produce these antioxidants decreases with aging. Therefore, antioxidant therapy alone or in combination with current treatment methods may represent an attractive strategy for treating or preventing the neurodegeneration seen in PD. Here, we summarize the recent discoveries of potential antioxidant compounds for modulating free-radical mediated oxidative stress leading to neurotoxicity in PD.

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Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease?

Silva,

Alves,

Soledade

et al. 2023

Marine Drugs

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The increase in the life expectancy average has led to a growing elderly population, thus leading to a prevalence of neurodegenerative disorders, such as Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder and is characterized by a progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). The marine environment has proven to be a source of unique and diverse chemical structures with great therapeutic potential to be used in the treatment of several pathologies, including neurodegenerative impairments. This review is focused on compounds isolated from marine organisms with neuroprotective activities on in vitro and in vivo models based on their chemical structures, taxonomy, neuroprotective effects, and their possible mechanism of action in PD. About 60 compounds isolated from marine bacteria, fungi, mollusk, sea cucumber, seaweed, soft coral, sponge, and starfish with neuroprotective potential on PD therapy are reported. Peptides, alkaloids, quinones, terpenes, polysaccharides, polyphenols, lipids, pigments, and mycotoxins were isolated from those marine organisms. They can act in several PD hallmarks, reducing oxidative stress, preventing mitochondrial dysfunction, α-synuclein aggregation, and blocking inflammatory pathways through the inhibition translocation of NF-kB factor, reduction of human tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6). This review gathers the marine natural products that have shown pharmacological activities acting on targets belonging to different intracellular signaling pathways related to PD development, which should be considered for future pre-clinical studies.

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Neuroprotective Compounds from Marine Microorganisms

Cited by 3 publications

References 52 publications

Recent Studies on the Therapeutic and Prophylactic Effect of Some Agents on Experimental Induced Parkinson Disease Models Review

Recent Studies on the Therapeutic and Prophylactic Effect of Some Agents on Experimental Induced Parkinson Disease Models Review

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Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease?

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