Neuroprotective and neuro-survival properties of safinamide against methamphetamine-induced neurodegeneration: Hypothetic possible role of BDNF/TrkB/PGC-1α signaling pathway and mitochondrial uncoupling protein −2(UCP-2)

Sepehr, Afrah; Taheri, Fereshteh; Heidarian, Sara; Motaghinejad, Majid; Safari, Sepideh

doi:10.1016/j.mehy.2020.110094

Cited by 10 publications

(13 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Irisin-mediated neuronal protection is closely related to BDNF (de Oliveira Bristot et al, 2019;Sepehr et al, 2020), which is a vital growth factor that is widely expressed in the central nervous system and plays an important role in neuronal maturation, synapse formation, and plasticity (Zaletel et al, 2017;de Oliveira Bristot et al, 2019;Sepehr et al, 2020). It has been confirmed that irisin exerts its neuroprotective effects by increasing the expression of BDNF (Huang et al, 2019).…”

Section: Discussionmentioning

confidence: 97%

“…UCP2 is regarded as an important signaling molecule related to neuronal survival (Dutra et al, 2018;de Oliveira Bristot et al, 2019). As an anion carrier protein located in the mitochondrial inner membrane, UCP2 is sensitive to mitochondrial membrane potential (de Oliveira Bristot et al, 2019;Sepehr et al, 2020). It has been verified that when mitochondrial membrane potential decreases, large amounts of calcium flow into the mitochondria, leading to ROS production and cell injury or even death (Nemani et al, 2018;Liu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Uncoupling protein 2 (UCP2) is one of the downstream proteins whose expression is regulated by BDNF (Sepehr et al, 2020). UCP2 is a mitochondrial inner membrane protein that is mainly expressed in the brain (Toda and Diano, 2014) and is known to have neuroprotective effects (Normoyle et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Cheng

Cui

Zhai

et al. 2021

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Cheng

Cui

Zhai

et al. 2021

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…BDNF is a major neurotrophic factor that functions in the maintenance and the survival of neurons ( Sepehr et al, 2020 ), TrkB and CREB plays a vital role in depression and antidepressant responses ( Sonoyama et al, 2020 ). Our study found that the expression of BDNF, TrkB and CREB in the offspring’s hippocampus are reduced after maternal stress during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Zhao

Wang

Wen

et al. 2022

PeerJ

View full text Add to dashboard Cite

Background Numerous studies have shown that exposure to prenatal maternal stress (PMS) is associated with various psychopathological outcomes of offspring. The accumulating evidence linking bacteria in the gut and neurons in the brain (the microbiota-gut-brain axis) has been aconsensus; however, there is a lack of research on the involvement mechanism of gut microbiota in the regulation of the BDNF/CREB signaling pathway in the hippocampus of prenatally stressed offspring. Methods Pregnant rats were subjected to chronic unpredictable mild stress (CUMS) to establish the prenatal maternal stress model. The body weight was measured and the behavioral changes were recorded. Offspring were tested to determine emotional state using sucrose preference test (SPT), open-field test (OFT) and suspended tail test (STT). Gut microbiota was evaluated by sequencing the microbial 16S rRNA V3–V4 region, and the interactive analysis of bacterial community structure and diversity was carried out. The expression of hippocampal BDNF, TrkB and CREB mRNA and proteins were respectively measured using RT-PCR and Western blotting. Results Prenatal maternal stress increased maternal plasma corticosterone levels, slowed maternal weight gain and caused depression-like behaviors (all P < 0.05). In offspring, prenatal maternal stress increased plasma corticosterone levels (P < 0.05) and emotional behavior changes (depression-like state) were observed (P < 0.05). The species abundance, diversity and composition of the offspring’s gut microbiota changed after the maternal stress during pregnancy (P < 0.05). Compared with the control group’s offspring, the species abundance of Lactobacillaceae was dropped, while the abundance of the Muribaculaceae species abundance was risen. Concurrent, changes in the hippocampal structure of the offspring and decreases in expression of BDNF/CREB signaling were noted (P < 0.05). Conclusions Prenatal maternal stress leads to high corticosterone status and abnormal emotion behavior of offspring, which may be associated with the abnormal BDNF/CREB signaling in hippocampus of offspring caused by the change of gut microbiota composition.

show abstract

“…Белки UCP стимулируют синаптогенез, нейрогенез и нейропластичность, обладают антиоксидантными свойствами [16]. Под действием UCP1 повышается экспрессия мозгового нейротрофического фактора (brain-derived neurotrophic factor, BDNF) [17]. Показано, что введение irisin, высвобождение которого провоцируется снижением температуры, уменьшает объем инфаркта мозга у крыс после окклюзии среднемозговой артерии, стабилизирует гематоэнцефалический барьер и стимулирует накопление BDNF, уменьшает объем повреждений миокарда и легких после тотальной остановки кровообращения [18][19][20].…”

Section: молекулярные механизмы низкотемпературных технологийunclassified

Mechanisms of low-temperature rehabilitation technologies. Extreme aerocriotherapy

Шевелев

Petrova

Yuriev

et al. 2021

Physical and rehabilitation medicine, medical rehabilitation

View full text Add to dashboard Cite

The mechanisms of increasing the resistance of cells to significant temperature and damaging effects are typical, and cellular tolerance, ensuring the effectiveness of systemic regulation, is an important part of increasing the adaptive and rehabilitative potential of the entire organism. The expression of early genes encoding a wide range of stress-protective proteins increases the resistance of cells not only to significant temperature stimuli, but also to ischemia, hypoxia, and other damaging factors, forming the effects of cross-adaptation. Even a small change in temperature is significant enough to trigger the processes of genomic reprogramming. It seems to us important to consider the mechanisms of low-temperature therapeutic and rehabilitation technologies from the standpoint of cellular response to temperature stimuli. Currently, a large number of low temperature technologies (HT) are used in medical rehabilitation, which can be divided into two groups: moderately low temperature effects (from 30C to +20C) and extremely low temperature effects (from 30C to 180C), which includes the technology of extreme aerocriotherapy (EACT). The purpose of the review is to analyze the systemic and local mechanisms of EACT implemented with the participation of the main known stress-protective proteins.

show abstract

Neuroprotective and neuro-survival properties of safinamide against methamphetamine-induced neurodegeneration: Hypothetic possible role of BDNF/TrkB/PGC-1α signaling pathway and mitochondrial uncoupling protein −2(UCP-2)

Cited by 10 publications

References 59 publications

Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Mechanisms of low-temperature rehabilitation technologies. Extreme aerocriotherapy

Contact Info

Product

Resources

About