Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Cheng, Yao; Cui, Yaru; Zhai, Yujie; Xin, Wenyu; Yu, Yan; Liang, Jia; Li, Shucui; Sun, Hongliu

doi:10.3389/fncel.2021.738533

Cited by 17 publications

(12 citation statements)

References 75 publications

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“…Physical exercise increases BDNF levels through PGC-1α activation and modulation of FNDC-5 expression (46). With the studies conducted in recent years, it has been confirmed that irisin exerts its neuroprotective effects by increasing the expression of BDNF (43,46). Considering the neuroprotective roles of irisin in accordance with previous studies, it is considered that both exogenous and endogenous irisin may provide protection against epilepsy-induced neuronal damage (43).…”

Section: Discussionmentioning

confidence: 66%

“…It has been demonstrated that irisin, an exercise-related hormone, can improve the mitochondrial functions and protect against many diseases by reducing the production of reactive oxygen species (ROS) (41). With various studies conducted in parallel with this, it has been confirmed that exogenous irisin treatment improved the mitochondrial dysfunction and significantly reduces the ROS levels (42,43).…”

Section: Discussionmentioning

confidence: 96%

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Effect of irisin on the epilepsy induced by penicillin G: An electrophysiological study

YILDIZ¹,

DEMİR²,

Beyazçiçek³

et al. 2022

J Exp Clin Med

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Epilepsy is a neurological disease characterized by sudden and synchronized seizures caused by abnormal and excessive electrical discharges in brain neurons. The purpose of this study was to electrophysiologically examine the effects of acute administration of irisin, which is thought to be neuroprotective and increase cell proliferation, at different doses (10 and 100 nM) on the penicillin-induced experimental epilepsy in rats. Fortynine adult male Wistar rats were used in the study. The rats were divided into 7 groups: sham, control group (penicillin), irisin group, the pre-and during-seizure groups of 10 nM and 100 nM irisin. All the substances except penicillin were administered intraperitoneally. The rats were anesthetized using urethane. The bone tissue on the left cerebral cortex was removed and the electrodes were placed in the somatomotor cortex. Thirty minutes before penicillin administration, irisin was administered to the pre-seizure penicillin group at doses of 10 nM and 100 nM. Then, penicillin (500 IU/2 µl) was injected intracortically, and ECoG recording was continued for 120 minutes. On the other hand, 10 nM and 100 nM of irisin were administered to the during-seizure penicillin group after penicillin was injected intracortically and the seizure occurred, and ECoG recording was continued for 120 minutes. The ECoG recordings were analyzed using the PowerLab Chart v.8 software. In conclusion, it was found that irisin prolonged the latency of initial epileptic activity and decreased the number and amplitude of spike-waves in the penicillin-induced experimental epilepsy model. These results suggest that irisin might have an antiepileptic potential.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 96%

Effect of irisin on the epilepsy induced by penicillin G: An electrophysiological study

YILDIZ¹,

DEMİR²,

Beyazçiçek³

et al. 2022

J Exp Clin Med

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“…After administering pentobarbital sodium (50 mg/kg, intraperitoneally, CAS, 57-33-0, Xiya Reagent, Chengdu, China), the brain was quickly removed, and the cortex and hippocampus were separated on ice, following which 0.01M PBS (10 μL/mg) was added to the samples, which were then cut using scissors on ice. Sequentially, the cut issue was filtered through a stainless steel mesh (200 mesh/inch) for the single-cell suspensions ( Cheng et al, 2021 ). In accordance with the instructions of the ROS Assay Kit (Beyotime, S0033, Shanghai, China), 500 μL DCFH-DA diluted with serum-free culture medium (1:1000, 10 μM/L) were added to the single cell suspensions (250 μL) for 40 min incubation at 37°C without daylight.…”

Section: Methodsmentioning

confidence: 99%

Attenuated iron stress and oxidative stress may participate in anti-seizure and neuroprotective roles of xenon in pentylenetetrazole-induced epileptogenesis

Zhang

Cheng

Zhai

et al. 2022

Front. Cell. Neurosci.

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The previous studies have demonstrated the excellent neuroprotective effects of xenon. In this study, we verified the anti-seizure and neuroprotective roles of xenon in epileptogenesis and evaluated the involvement of oxidative stress and iron accumulation in the protective roles of xenon. Epileptogenesis was induced by pentylenetetrazole (PTZ) treatment in Sprague-Dawley rats. During epileptogenesis, we found increased levels of iron and oxidative stress accompanied by elevated levels of divalent metal transporter protein 1 and iron regulatory protein 1, which are closely associated with iron accumulation. Meanwhile, the levels of autophagy and mitophagy increased, alongside significant neuronal damage and cognitive deficits. Xenon treatment reversed these effects: oxidative stress and iron stress were reduced, neuronal injury and seizure severity were attenuated, and learning and memory deficits were improved. Thus, our results confirmed the neuroprotective and anti-seizure effects of xenon treatment in PTZ-induced epileptogenesis. The reduction in oxidative and iron stress may be the main mechanisms underlying xenon treatment. Thus, this study provides a potential intervention strategy for epileptogenesis.

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“…It seems feasible that irisin is implemented in the realization of the mechanical link between exercises and changes in the neuronal cells leading, in analogy to peripheral effects, to adaptive adjustment of lipid metabolism, cellular excitation, and antioxidant systems in neurons and glia ( Stranahan et al, 2010 ). Effects of exogenous irisin ( Cheng et al, 2021 ) or irisin gene knockdown ( Islam et al, 2021 ) on animals’ behavior indicate that it also provides a functionally relevant signaling in the brain.…”

Section: Irisin Is Linking Pes To Neuroplasticity and Autophagy In Th...mentioning

confidence: 99%

“…The myokine irisin initially garnered attention for its paracrine signaling leading to white to brown fat cell transformation and, upon its chronic action, to adaptation of muscle and bone tissue to increased physical load ( Li H. et al, 2019 ; Waseem et al, 2022 ). However, effects of exogenous irisin ( Cheng et al, 2021 ) or irisin gene knockdown ( Islam et al, 2021 ) on animals’ behavior indicate that endogenous irisin stands behind activation of the muscle-brain axis and act as signaling molecule in the brain.…”

Section: Introductionmentioning

confidence: 99%

Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD

Abdulghani

Poghosyan

Mehren

et al. 2023

Front. Mol. Neurosci.

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Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Abstract: Graphical AbstractOur study confirmed significant anti-oxidative stress and neuroprotective effects of exogenous irisin in KA-induced SE. Moreover, the BDNF/UCP2 pathway may contribute to the mechanism underlying the neuroprotective effects of irisin.

Cited by 17 publications

References 75 publications

Effect of irisin on the epilepsy induced by penicillin G: An electrophysiological study

Effect of irisin on the epilepsy induced by penicillin G: An electrophysiological study

Attenuated iron stress and oxidative stress may participate in anti-seizure and neuroprotective roles of xenon in pentylenetetrazole-induced epileptogenesis

Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD

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