Neuroprotective and antioxidant potential of terpenoid fraction from<i>Hygrophila auriculata</i>against transient global cerebral ischemia in rats

Kanhere, Rupesh S.; Anjana, Ashwini; Anbu, J.; Sumithra, M.; H, Nazeer Ahamed K F

doi:10.3109/13880209.2012.716851

Cited by 20 publications

(10 citation statements)

References 38 publications

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“…66 Terpenoids extracted from other S. platensis strains have also been reported for its neuroprotective activities against oxidative stress. 67,68 According to our results, organic solvent extracts showed stronger antioxidant activities than water extract.…”

Section: Discussionmentioning

confidence: 65%

Phytochemical Profiling and in vitro Screening for Neuritogenic and Antioxidant Activities of Spirulina platensis

Ngu¹,

Ko²,

Tan³

et al. 2021

IJPER

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Background: In neurological diseases, neuronal loss is frequently associated with overproduction of free radicals and reduced level of endogenous neurotrophic factors. The blue-green microalga, Spirulina platensis is a well-known superfood with a high content of diverse nutrients and possesses several therapeutic properties. Here, we aimed to study the neuritogenic and antioxidant activities of Spirulina platensis UMACC 159. Materials and Methods: PC-12Adh (rat pheochromocytoma) cell was used to investigate the cytotoxicity effect of S. platensis UMACC 159 extracts (water, methanol, and ethanol) via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Neuritogenic activity of the extracts towards PC-12Adh cell line was studied using neurite outgrowth assay and immunofluorescence imaging of neurofilaments. The extracts were screened for the phytochemical contents, and antioxidant activities using 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-Diphenyl-1pircrylhydrazyl (DPPH) and reducing power. Results: Ethanol extract was found to exhibit the highest neuritogenic effect and enhanced the cytoskeleton formation in PC-12Adh cells at 6.25 µg/mL. Ethanol extract also showed the highest total phenolic content (49.09 ± 1.35 mg GAE/g), ABTS (EC 50 of 1.34 ± 0.01 mg/mL) and DPPH (EC 50 of 0.45 ± 0.04 mg/mL) scavenging activities (P ≤ 0.05), suggesting that the neuritogenic effect of ethanol extract was attributed to the phenolic compound(s) via antioxidant activity. Conclusion: Ethanol extract contains bioactive compound(s) with similar neuritogenic activity as nerve growth factor for neuronal survival, growth, and axonal regeneration. S. platensis has been proposed as a promising cognitive supplement.

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Section: Discussionmentioning

confidence: 65%

Phytochemical Profiling and in vitro Screening for Neuritogenic and Antioxidant Activities of Spirulina platensis

Ngu¹,

Ko²,

Tan³

et al. 2021

IJPER

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“…In the investigation, thymol, at a dose of 2.5 mg/kg for four weeks, attenuated neuronal loss and inflammation and was related to the preservation of antioxidant networks of defense. Fractions of Hygrophila auriculata –derived terpenoids (100 and 200 mg/kg) reflected neuroprotective activity in CA1 neurons of the hippocampus, hand in hand with antioxidative restoration [ 179 ]. Similarly, terpenoids have been marked for potential mechanisms, such as boosting the activity of glutamate decarboxylase enzyme, as well as GABA in the brain [ 107 , 180 ].…”

Section: Neuroprotective Mechanistic Narratives Of Active Principles ...mentioning

confidence: 99%

Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules

Oyeyinka

Afolayan

2022

Foods

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Active principles in plant-based foods, especially staple fruits, such as bananas and plantains, possess inter-related anti-inflammatory, anti-apoptotic, antioxidative, and neuromodulatory activities. Neurodegenerative diseases affect the functionality of the central and peripheral nervous system, with attendant cognitive deficits being hallmarks of these conditions. The dietary constitution of a wide range of bioactive compounds identified in this review further iterates the significance of the banana and plantain in compromising, halting, or preventing the pathological mechanisms of neurological disorders. The neuroprotective mechanisms of these biomolecules have been identified by using protein expression regulation and specific gene/pathway targeting, such as the nuclear and tumor necrosis factors, extracellular signal-regulated and mitogen-activated protein kinases, activator protein-1, and the glial fibrillary acidic protein. This review establishes the potential double-edged neuro-pharmacological fingerprints of banana and plantain fruits in their traditionally consumed pulp and less utilized peel component for human nutrition.

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“…This plant is marked as 'Rasayana' in Ayurveda which means drugs for the treatment of neurological disorders. Furthermore, the ethanolic terpenoid fraction of this plant has been reported to reverse the reduction in the glutathione (GSH) activity in cortex and hippocampal regions of the brain [96] . GSH is responsible for the synthesis and release of various molecules such as glutamate and GABA which coordinate the NMDA & non-NMDA activity [97] .…”

Section: Terpenoidsmentioning

confidence: 99%

Natural bioactive products with antioxidant properties useful in neurodegenerative diseases

Kumar¹,

Verma²

2020

Pharma Innovation

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Oxidative stress is one of the principal causes behind the progression of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, neurosclerosis and others. Reactive oxygen species and reactive nitrogen species are the major reduced moieties produced during the cellular oxidative stress which are responsible for the neural damage and death. Therefore, the compounds or group of compounds which are capable of limiting the concentration of these reduced form of oxygen commonly known as antioxidants can be the promising elements in controlling or recovering the neurodegenerative diseases. This article deals with various naturally active antioxidants which have been evidenced in the management of the neurodegenerative diseases. In this context, we have concluded the role of polyphenols, alkaloids, vitamins, terpenoids and several other bioactive compounds in the preventive and curative measures of different neurological disorders.

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Neuroprotective and antioxidant potential of terpenoid fraction fromHygrophila auriculataagainst transient global cerebral ischemia in rats

Cited by 20 publications

References 38 publications

Phytochemical Profiling and in vitro Screening for Neuritogenic and Antioxidant Activities of Spirulina platensis

Phytochemical Profiling and in vitro Screening for Neuritogenic and Antioxidant Activities of Spirulina platensis

Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules

Natural bioactive products with antioxidant properties useful in neurodegenerative diseases

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