Banana and plantain contribute significantly to food security and amelioration of malnutrition, earning their status as staples in several localities of tropical and sub-tropical regions. The distribution of metabolites within the various parts also remains as a key essential to their nutritive and therapeutic potential. This study was aimed at evaluating the nutritional and mineral composition of the flesh, peel, and peel extract components of Musa sinensis L. and Musa paradisiaca L. fruits as well as their nutritional and therapeutic potentials. Proximate and antinutritional analyses were carried out using standard analytical methods of the Association of Official Analytical Chemists (AOAC), while the mineral constituents were evaluated using inductively coupled plasma optical emission spectroscopy (ICP-OES). Proximate analysis revealed that the flesh and peel of M. sinensis L. and M. paradisiaca L. contain substantial amounts of moisture, fiber, carbohydrates, and low fat content, while minerals K, Mg, Ca, Na, P, and N were substantially concentrated in the peels and peel extracts in particular. The antinutrients alkaloid, oxalate, saponin, and phytate were detected in safe amounts according to the World Health Organization (WHO). The study points out that the peel and its derivative extract, as well as the flesh of M. sinensis L. and M. paradisiaca L. are to be put to more relevant human nutritional and therapeutic use.Primary metabolites from plants like fatty acids, carbohydrates, dietary fiber, and amino acids are central in the developmental and physiological processes in plants, while secondary metabolites (e.g., phenolics, carotenoids, sterols) are involved in plant protection and pollinator attraction [9,10].The banana (Musa sinensis L.) and plantain (Musa paradisiaca L.) belong to the Musaceae family and have been available for human use for ages [11,12]. They have marked morphological similarities and are of economic and nutritional value. Banana and plantain are majorly tropical plants, but do not grow in temperate regions. They grow predominantly in the continents of Asia, South America, and the tropical African sub-continent [13]. M. sinensis and M. paradisiaca fruits are essentially good potassium-based dietary items and serve as staples in many global cultures. Potassium is useful in ensuring proper muscular functioning [14]. M. sinensis and M. paradisiaca fruits are utilized in beverage production, especially among subsistence farmers [15], while other parts, including the roots and flowers are medicinally useful.The nutritional and therapeutic values of M. sinensis and M. paradisiaca fruit flesh are undisputedly clear. However, this study was undertaken to evaluate and establish the nutritive, therapeutic, and pharmacological potentials of M. sinensis and M. paradisiaca flesh, peels, and their derivative dietary product, to improve the dietary acceptability and reduce biological wastage respectively of their peels (exocarp). Results Proximal Content

Nutritional quality and the well-being of the body system are directly linked aspects of human survival. From the unborn foetus to adulthood, the need for sustainable access to micronutrient-rich foods is pertinent and the global consumption of banana and plantain fruits, in effect, contributes to the alleviation of the scourge of malnutrition. This review is particularly aimed at evaluating the pharmacological dimensions through the biological mechanisms of Musa fruits in the body, which represent correlations with their constituent micronutrient factors and dietary polyphenolic constituents such as minerals, vitamin members, anthocyanins, lutein, α-,β- carotenes, neoxanthins and cryptoxanthins, epi- and gallo catechins, catecholamines, 3-carboxycoumarin, β-sitosterol, monoterpenoids, with series of analytical approaches for the various identified compounds being highlighted therein. Derivative value-products from the compartments (flesh and peel) of Musa fruits are equally highlighted, bringing forth the biomedicinal and nutritional relevance, including the potentials of Musa species in dietary diversification approaches.

Secondary metabolites and their biological activity have pharmacological relevance in the prevention and therapeutic management of disease, including the facilitation of normal physiological processes through biochemical mechanisms. In this study, phytochemical constituents and antioxidant activity were evaluated quantitatively on the acetone, ethanol, and aqueous extracts of the flesh, and peel, as well as the boiled peel extract compartments of Musa sinensis L. and Musa paradisiaca L. fruits. Total phenol, proanthocyanidin, and flavonoid contents were estimated and measured spectrophotometrically. The free radical scavenging antioxidant capacity of the extracts was tested on DPPH (2,2-diphenyl-1-picrylhydrazyl ethanol), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)), and FRAP (ferric reducing antioxidant power) assay models. Correlation between phytoconstituents and antioxidant activity was analysed using Pearson’s coefficient. The results showed varying amounts of phytochemicals in the solvent extracts of the flesh and peel, including the boiled peel extract of M. sinensis and M. paradisiaca. All acetone extracts of M. sinensis flesh, M. paradisiaca flesh, and M. paradisiaca peel had the highest phytochemical contents, with the exception of the ethanol extract of M. sinensis peel which had the highest phenol content; just as on the overall scale, the peel compartments had generally higher phytochemical profiles than the soft flesh in both fruits. The boiled peel extracts of M. sinensis and M. paradisiaca had the highest ABTS (0.03 mg/mL) and DPPH (0.03 mg/mL) activity. Ferric reducing power (FRAP) was the highest in the ethanol extracts of M. sinensis flesh and peel, and M. paradisiaca flesh, while it was the highest in the acetone extract of M. paradisiaca at the peak concentration used (0.1 mg/mL). There was a significant negative correlation between the total phenol and flavonoid contents of M. sinensis flesh with its DPPH radical scavenging activity and proanthocyanidin content of M. paradisiaca flesh with its DPPH radical scavenging activity. The correlation outcomes indicate that none of the phytochemical constituents solely affected antioxidant activity; instead, a combination of the polyphenolic constituents contributed to antioxidant activity. This study shows the therapeutic potentials of the flesh and, importantly, the peel of M. sinensis and M. paradisiaca fruits on the basis of the polyphenolic constitution against free radicals and oxidative stress.

Objectives Spondias mombin is traditionally used as an herbal medicine for several human diseases and ailments in the tropical regions across the globe including the African countries. This study aimed to provide comprehensive information on nutritional benefits, ethnomedicinal uses, phytochemical constituents, pharmacological properties and toxicology study of S. mombin. Information was gathered from documented literatures in scientific database. Key findings The study revealed that S. mombin has nutritional values; with the leaf, fruit, flower, seed, and stem bark possessing a wide range of ethnomedicinal uses across several regions, with documented pharmacological properties. S. mombin has a frequent rate of ethnomedicinal utility in cases of abortion, constipation, fever, gonorrhea, postpartum hemorrhage, digestive pain, diarrhoea, dysentery and wounds. Ethnopharmacological studies showed that crude extracts and chemical compounds from S. mombin manifested in vivo and in vitro biological and pharmacological activities. About 102 isolated compounds from the leaf, fruit, or stem bark of S. mombin have been reported. Summary Overall, S. mombin has several nutritive and ethnomedicinal benefits owing to its chemical constituents, which are linkable to the several pharmacological activities. There remains however, the need for dosage intake caution, upon the advice of medical professionals.

Active principles in plant-based foods, especially staple fruits, such as bananas and plantains, possess inter-related anti-inflammatory, anti-apoptotic, antioxidative, and neuromodulatory activities. Neurodegenerative diseases affect the functionality of the central and peripheral nervous system, with attendant cognitive deficits being hallmarks of these conditions. The dietary constitution of a wide range of bioactive compounds identified in this review further iterates the significance of the banana and plantain in compromising, halting, or preventing the pathological mechanisms of neurological disorders. The neuroprotective mechanisms of these biomolecules have been identified by using protein expression regulation and specific gene/pathway targeting, such as the nuclear and tumor necrosis factors, extracellular signal-regulated and mitogen-activated protein kinases, activator protein-1, and the glial fibrillary acidic protein. This review establishes the potential double-edged neuro-pharmacological fingerprints of banana and plantain fruits in their traditionally consumed pulp and less utilized peel component for human nutrition.