Neuroprotective activity of mexidole and 3-hydroxypyridine acetylcysteinate against the background of cerebral ischemia in the complex of experimental diabetes mellitus and exogenous hypercholesterolemia

Abstract

We studied the interaction of mexidol and 3-hydroxypyridine acetylcysteinate on the model of experimental ischemic stroke in rats. The preparations were effective in a dose 50 mg/kg (10-day treatment): they reduced the incidence of neurological disturbances (pareses, sensitivity disturbances) and improved antioxidant defense of the plasma.

Evaluation of Effects of Histochrome and Mexidol on Structural and Functional Characteristics of the Brain in Senescence-Accelerated OXYS Rats by Magnetic Resonance Imaging

“…Its creation is acknowledged as an obvious success of the Russian science. Mexidol has many indications for use, but is most often used and most effective as a neuroprotector [3].…”